SNRPD3

SNRPD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D3B, 3CW1, 3PGW, 3VRI, 4PJO, 4WZJ, 3JCR
Identifiers
Aliases	SNRPD3 , SMD3, Sm-D3, small nuclear ribonucleoprotein D3 polypeptide
External IDs	OMIM: 601062 MGI: 1914582 HomoloGene: 3078 GeneCards: SNRPD3
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.23 Start 24,555,958 bp [1] End 24,582,052 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 75,353,385 bp [2] End 75,373,215 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence islet of Langerhans monocyte appendix duodenum rectum skeletal muscle tissue gastrocnemius muscle smooth muscle tissue lymph node Top expressed in abdominal wall otic placode somite maxillary prominence endocardial cushion dermis hand primitive streak yolk sac ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function histone pre-mRNA DCP binding U2 snRNA binding protein binding enzyme binding U7 snRNA binding telomerase RNA binding U1 snRNP binding RNA binding Cellular component SMN-Sm protein complex cytosol prespliceosome catalytic step 2 spliceosome spliceosomal tri-snRNP complex U5 snRNP U12-type spliceosomal complex U2 snRNP nucleoplasm methylosome U7 snRNP precatalytic spliceosome small nuclear ribonucleoprotein complex pICln-Sm protein complex telomerase holoenzyme complex spliceosomal complex commitment complex U4 snRNP extracellular exosome nucleus U1 snRNP cytoplasm nuclear body U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription RNA processing mRNA processing spliceosomal complex assembly RNA splicing histone mRNA metabolic process protein methylation import into nucleus spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6634 67332 Ensembl ENSG00000100028 ENSMUSG00000020180 UniProt P62318 P62320 RefSeq (mRNA) NM_001278656 NM_004175 NM_026095 RefSeq (protein) NP_001265585 NP_004166 NP_080371 Location (UCSC) Chr 22: 24.56 – 24.58 Mb Chr 10: 75.35 – 75.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. ^[7]

Interactions

SNRPD3 has been shown to interact with:

• CDC5L, ^[8]
• CLNS1A, ^[9]
• DDX20, ^[10] and
• Protein arginine methyltransferase 5. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000100028 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020180 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lehmeier T, Foulaki K, Lührmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC   332598 . PMID   1701240.
6. Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A. 91 (25): 12317–21. Bibcode:1994PNAS...9112317L. doi: 10.1073/pnas.91.25.12317 . PMC   45428 . PMID   7527560.
7. "Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa".
8. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.
9. Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC   99994 . PMID   11713266.
10. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC   2168095 . PMID   10601333.

Further reading

• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi: 10.1016/S0092-8674(00)80367-0 . PMID   9323129.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID   9417867.
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi: 10.1016/S0092-8674(00)80550-4 . PMID   10025403.
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC   2168095 . PMID   10601333.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC   2174312 . PMID   10725331.
• Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R (2000). "The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies". J. Biol. Chem. 275 (22): 17122–9. doi: 10.1074/jbc.M000300200 . hdl: 11858/00-001M-0000-0012-F7F0-E . PMID   10747894.
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC   140196 . PMID   11226169.
• Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets". Mol. Cell. 7 (5): 1111–7. doi: 10.1016/S1097-2765(01)00244-1 . PMID   11389857.
• Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC   99994 . PMID   11713266.
• Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi: 10.1074/jbc.M109448200 . PMID   11714716.
• Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol. 11 (24): 1990–4. doi:10.1016/S0960-9822(01)00592-9. hdl: 11858/00-001M-0000-0012-F501-7 . PMID   11747828. S2CID   14742376.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi: 10.1074/jbc.M110141200 . PMID   11748230.
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi: 10.1074/jbc.M109984200 . PMID   11756452.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID   11780068. S2CID   1518837.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi: 10.1074/jbc.M203478200 . PMID   12065586.