Small nuclear ribonucleoprotein polypeptide F

Last updated
SNRPF
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNRPF , SMF, Sm-F, snRNP-F, Small nuclear ribonucleoprotein polypeptide F
External IDs OMIM: 603541 MGI: 1917128 HomoloGene: 130366 GeneCards: SNRPF
Gene location (Human)
Ideogram human chromosome 12.svg
Chr. Chromosome 12 (human) [1]
Human chromosome 12 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 12q23.1Start95,858,928 bp [1]
End95,903,828 bp [1]
RNA expression pattern
PBB GE SNRPF 203832 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003095

NM_027246

RefSeq (protein)

NP_003086

NP_081522

Location (UCSC) Chr 12: 95.86 – 95.9 Mb Chr 10: 93.58 – 93.59 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene. [5] [6]

Contents

Interactions

Small nuclear ribonucleoprotein polypeptide F has been shown to interact with DDX20, [7] Small nuclear ribonucleoprotein D2 [8] and Small nuclear ribonucleoprotein polypeptide E. [8]

Related Research Articles

snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.

Dr. Gideon Dreyfuss is the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine and an investigator of the Howard Hughes Medical Institute. He was elected to the National Academy of Sciences in 2012.

LSm InterPro Domain

In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins. LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules, and play a large number of various roles in mRNA processing and regulation.

U1 spliceosomal RNA

U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP, an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. Splicing, or the removal of introns, is a major aspect of post-transcriptional modification, and takes place only in the nucleus of eukaryotes.

Survival of motor neuron InterPro Domain

Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.

Fibrillarin protein-coding gene in the species Homo sapiens

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

Small nuclear ribonucleoprotein D1 protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

SNRPB protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

Small nuclear ribonucleoprotein D2 protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene.

Small nuclear ribonucleoprotein polypeptide E protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.

SNRPD3 protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

Gem-associated protein 2 protein-coding gene in the species Homo sapiens

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.

DDX20 protein-coding gene in the species Homo sapiens

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

SNRPB2 protein-coding gene in the species Homo sapiens

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

SNRPG protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.

Small nuclear ribonucleoprotein polypeptide C protein-coding gene in the species Homo sapiens

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.

Gem-associated protein 6 protein-coding gene in the species Homo sapiens

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.The gem-associated proteins are those found in the gems of Cajal bodies.

LSM2 protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.

Gem-associated protein 4 protein-coding gene in the species Homo sapiens

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

Gem-associated protein 5 protein-coding gene in the species Homo sapiens

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000139343 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020018 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R (May 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". The EMBO Journal. 14 (9): 2076–88. doi:10.1002/j.1460-2075.1995.tb07199.x. PMC   398308 . PMID   7744013.
  6. "Entrez Gene: SNRPF small nuclear ribonucleoprotein polypeptide F".
  7. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC   2168095 . PMID   10601333.
  8. 1 2 Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID   9417867.

Further reading