ASCC3L1

SNRNP200
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q0Z, 4F91, 4F92, 4F93, 4KIT, 3JCR
Identifiers
Aliases	SNRNP200 , ASCC3L1, BRR2, HELIC2, RP33, U5-200KD, small nuclear ribonucleoprotein U5 subunit 200
External IDs	OMIM: 601664 MGI: 2444401 HomoloGene: 5859 GeneCards: SNRNP200
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,321,271 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,082,371 bp
RNA expression pattern
	Top expressed in
	embryo; ; ganglionic eminence; ; urethra; ; parotid gland; ; pylorus; ; nipple; ; tibia; ; cancellous bone; ; lactiferous duct; ; right uterine tube;
	Top expressed in
	hand; ; maxillary prominence; ; primitive streak; ; condyle; ; abdominal wall; ; Paneth cell; ; otolith organ; ; hair follicle; ; fossa; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; helicase activity ; protein binding ; identical protein binding ; nucleic acid binding ; hydrolase activity ; ATP binding ; RNA binding ;
Cellular component	catalytic step 2 spliceosome ; membrane ; U5 snRNP ; nucleoplasm ; spliceosomal complex ; nucleus ; U4/U6 x U5 tri-snRNP complex ; post-mRNA release spliceosomal complex ;
Biological process	mRNA splicing, via spliceosome ; mRNA processing ; osteoblast differentiation ; cis assembly of pre-catalytic spliceosome ; RNA splicing ; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) ;
	Sources:Amigo / QuickGO
Orthologs
	23020
	320632
	ENSG00000144028
	ENSMUSG00000003660
	O75643
	Q6P4T2
	NM_014014
	NM_177214
	NP_054733
	NP_796188
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 17, 2022

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.^[5]^[6]^[7]^[8]^[9]

Related Research Articles

A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. Small nuclear RNA (snRNA) molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex, which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. The spliceosome removes introns from a transcribed pre-mRNA, a type of primary transcript. This process is generally referred to as splicing. An analogy is a film editor, who selectively cuts out irrelevant or incorrect material from the initial film and sends the cleaned-up version to the director for the final cut.

Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.

PRP31 pre-mRNA processing factor 31 homolog , also known as PRPF31, is a protein which in humans is encoded by the PRPF31 gene.

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

Survival of motor neuron-related-splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene.

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.

Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene.

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.

RNA-binding protein 28 is a protein that in humans is encoded by the RBM28 gene. It is a nucleolar component of the spliceosomal ribonucleoprotein complexes.

Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144028 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003660 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID 9872452.
↑ Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Luhrmann R (Oct 1996). "The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases". EMBO J. 15 (15): 4001–15. doi:10.1002/j.1460-2075.1996.tb00774.x. PMC 452120 . PMID 8670905.
↑ Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R (Nov 1998). "The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein". Mol Cell Biol. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259 . PMID 9774689.
↑ Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A. 95 (8): 4188–92. Bibcode:1998PNAS...95.4188L. doi: 10.1073/pnas.95.8.4188 . PMC 22463 . PMID 9539711.
↑ "Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1".

External links

Human SNRNP200 genome location and SNRNP200 gene details page in the UCSC Genome Browser .

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Laggerbauer B, Lauber J, Lührmann R (1996). "Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs". Nucleic Acids Res. 24 (5): 868–75. doi:10.1093/nar/24.5.868. PMC 145735 . PMID 8600454.
Meister G, Hannus S, Plöttner O, et al. (2001). "SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome". EMBO J. 20 (9): 2304–14. doi:10.1093/emboj/20.9.2304. PMC 125440 . PMID 11331595.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266 . PMID 11991638.
Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341 . PMID 12403470.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585 . PMID 15146077.
Vertegaal AC, Ogg SC, Jaffray E, et al. (2004). "A proteomic study of SUMO-2 target proteins". J. Biol. Chem. 279 (32): 33791–8. doi: 10.1074/jbc.M404201200 . PMID 15175327.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.

This enzyme-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144028 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003660 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID 9872452.

[pmid8670905-6] Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Luhrmann R (Oct 1996). "The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases". EMBO J. 15 (15): 4001–15. doi:10.1002/j.1460-2075.1996.tb00774.x. PMC 452120 . PMID 8670905.

[pmid9774689-7] Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R (Nov 1998). "The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein". Mol Cell Biol. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259 . PMID 9774689.

[pmid9539711-8] Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A. 95 (8): 4188–92. Bibcode:1998PNAS...95.4188L. doi: 10.1073/pnas.95.8.4188 . PMC 22463 . PMID 9539711.

[entrez-9] "Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

ASCC3L1

Contents

Related Research Articles

References

External links

Further reading