SNRPA1

SNRPA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A9N
Identifiers
Aliases	SNRPA1 , Lea1, small nuclear ribonucleoprotein polypeptide A', U2A'
External IDs	OMIM: 603521 MGI: 1916231 HomoloGene: 2325 GeneCards: SNRPA1
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,724,335 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; lymph node; ; thymus; ; bone marrow; ; spleen; ; monocyte; ; appendix; ; tibial nerve; ; right lung; ; rectum;
	Top expressed in
	primitive streak; ; Paneth cell; ; condyle; ; fossa; ; abdominal wall; ; superior cervical ganglion; ; motor neuron; ; medullary collecting duct; ; ureter; ; vas deferens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	U2 snRNA binding ; protein binding ; RNA binding ;
Cellular component	catalytic step 2 spliceosome ; spliceosomal complex ; small nuclear ribonucleoprotein complex ; nucleus ; U2 snRNP ; nucleoplasm ; nuclear speck ; nuclear body ; U2-type precatalytic spliceosome ; U2-type catalytic step 2 spliceosome ; viral nucleocapsid ;
Biological process	mRNA splicing, via spliceosome ; mRNA processing ; RNA splicing ; interleukin-12-mediated signaling pathway ; spermatogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	6627
	68981
	n/a
	ENSMUSG00000030512
	P09661
	P57784
	NM_003090
	NM_021336
	NP_003081
	NP_067311
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.^[4]^[5]

Interactions

SNRPA1 has been shown to interact with CDC5L.^[6]

Related Research Articles

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene.

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.

Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the SRRM1 gene.

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene.

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.

116 kDa U5 small nuclear ribonucleoprotein component is a protein that in humans is encoded by the EFTUD2 gene.

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

Survival of motor neuron-related-splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene.

WD repeat domain 57 , also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030512 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (March 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Research. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531 . PMID 2928112.
↑ "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846 . PMID 11101529.

Ohno M, Kataoka N, Shimura Y (December 1990). "A nuclear cap binding protein from HeLa cells". Nucleic Acids Research. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC 332760 . PMID 2148205.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kjems J, Sharp PA (August 1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". Journal of Virology. 67 (8): 4769–76. doi:10.1128/JVI.67.8.4769-4776.1993. PMC 237863 . PMID 8331728.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672 . PMID 9531537.
Price SR, Evans PR, Nagai K (August 1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. Bibcode:1998Natur.394..645P. doi:10.1038/29234. PMID 9716128. S2CID 204999419.
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, et al. (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (May 1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi: 10.1073/pnas.96.11.6125 . PMC 26846 . PMID 10339552.
Lundin M, Mikkelsen B, Gudim M, Syed M (March 2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine Biotechnology. 2 (2): 204–211. doi:10.1007/s101269900015. PMID 10811961. S2CID 20060370.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068. S2CID 1518837.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266 . PMID 11991638.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030512 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2928112-4] Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (March 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Research. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531 . PMID 2928112.

[entrez-5] "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".

[pmid11101529-6] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846 . PMID 11101529.

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[6]

v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

SNRPA1

Contents

Interactions

Related Research Articles

References

Further reading