SNRPA1

SNRPA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9N
Identifiers
Aliases	SNRPA1 , Lea1, small nuclear ribonucleoprotein polypeptide A', U2A'
External IDs	OMIM: 603521; MGI: 1916231; HomoloGene: 2325; GeneCards: SNRPA1; OMA:SNRPA1 - orthologs
Gene location (Mouse) Chr. Chromosome 7 (mouse) [1] Band 7|7 C Start 65,708,751 bp [1] End 65,724,335 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen lymph node thymus bone marrow spleen monocyte appendix tibial nerve right lung rectum Top expressed in primitive streak Paneth cell condyle fossa abdominal wall epiblast superior cervical ganglion motor neuron medullary collecting duct embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function U2 snRNA binding protein binding RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex small nuclear ribonucleoprotein complex nucleus U2 snRNP nucleoplasm nuclear speck nuclear body U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome viral nucleocapsid Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing interleukin-12-mediated signaling pathway spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6627 68981 Ensembl n/a ENSMUSG00000030512 UniProt P09661 P57784 RefSeq (mRNA) NM_003090 NM_021336 RefSeq (protein) NP_003081 NP_067311 Location (UCSC) n/a Chr 7: 65.71 – 65.72 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene. ^{[4] [5]}

Interactions

SNRPA1 has been shown to interact with CDC5L. ^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000030512 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (March 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Research. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC   317531 . PMID   2928112.
5. "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
6. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.

Further reading

• Ohno M, Kataoka N, Shimura Y (December 1990). "A nuclear cap binding protein from HeLa cells". Nucleic Acids Research. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC   332760 . PMID   2148205.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Kjems J, Sharp PA (August 1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". Journal of Virology. 67 (8): 4769–76. doi:10.1128/JVI.67.8.4769-4776.1993. PMC   237863 . PMID   8331728.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC   316672 . PMID   9531537.
• Price SR, Evans PR, Nagai K (August 1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. Bibcode:1998Natur.394..645P. doi:10.1038/29234. PMID   9716128. S2CID   204999419.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, et al. (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID   9731529. S2CID   585778.
• Eldridge AG, Li Y, Sharp PA, Blencowe BJ (May 1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi: 10.1073/pnas.96.11.6125 . PMC   26846 . PMID   10339552.
• Lundin M, Mikkelsen B, Gudim M, Syed M (March 2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine Biotechnology. 2 (2): 204–211. doi:10.1007/s101269900015. PMID   10811961. S2CID   20060370.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID   11780068. S2CID   1518837.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4) S1355838202021088: 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.