Small nuclear ribonucleoprotein polypeptide A

SNRPA
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1AUD, 1DRZ, 1DZ5, 1FHT, 1M5K, 1M5O, 1M5P, 1M5V, 1NU4, 1OIA, 1SJ3, 1SJ4, 1SJF, 1U6B, 1URN, 1VBX, 1VBY, 1VBZ, 1VC0, 1VC5, 1VC6, 1ZZN, 2A3J, 2NZ4, 2OIH, 2OJ3, 2U1A, 3BO2, 3BO3, 3BO4, 3CUL, 3CUN, 3EGZ, 3G8S, 3G8T, 3G96, 3G9C, 3HHN, 3IIN, 3IRW, 3IWN, 3K0J, 3L3C, 3MUM, 3MUR, 3MUT, 3MUV, 3MXH, 3P49, 3PGW, 3R1H, 3R1L, 3UCU, 3UCZ, 3UD3, 3UD4, 4C4W, 4PR6, 4PRF, 4W90, 4YB1, 5DDO, 5DDR, 5DDQ, 5DDP, 5FJ4 Contents Interactions ; References ; Further reading ;
Identifiers
Aliases	SNRPA , Mud1, U1-A, U1A, Small nuclear ribonucleoprotein polypeptide A
External IDs	OMIM: 182285 HomoloGene: 3380 GeneCards: SNRPA
Gene location (Human)
Chr.	Chromosome 19 (human)
End	40,765,389 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; canal of the cervix; ; right lobe of thyroid gland; ; popliteal artery; ; left lobe of thyroid gland; ; spleen; ; gastric mucosa; ; anterior pituitary; ; left coronary artery; ; lymph node;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	U1 snRNA binding ; snRNA stem-loop binding ; protein binding ; RNA binding ; nucleic acid binding ; U1 snRNP binding ; identical protein binding ;
Cellular component	spliceosomal complex ; nucleus ; nucleoplasm ; U1 snRNP ;
Biological process	mRNA processing ; regulation of mRNA polyadenylation ; RNA splicing ; mRNA splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	6626
	n/a
	ENSG00000077312
	n/a
	P09012
	n/a
	NM_004596
	n/a
	NP_004587
	n/a
	Wikidata
View/Edit Human

Last updated July 24, 2022

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.^[3]^[4]

Interactions

Small nuclear ribonucleoprotein polypeptide A has been shown to interact with CDC5L.^[5]

Related Research Articles

snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.

U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP, an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. Splicing, or the removal of introns, is a major aspect of post-transcriptional modification, and takes place only in the nucleus of eukaryotes.

U4 spliceosomal RNA Non-coding RNA component of the spliceosome

The U4 small nuclear Ribo-Nucleic Acid is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

Heterogeneous nuclear ribonucleoproteins C1/C2 is a protein that in humans is encoded by the HNRNPC gene.

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene.

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.

Kiyoshi Nagai was a Japanese structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK. He was known for his work on the mechanism of RNA splicing and structures of the spliceosome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077312 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A (January 1991). "Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region". Cytogenetics and Cell Genetics. 54 (1–2): 15–9. doi:10.1159/000132946. PMID 1701111.
↑ "Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A".
↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846 . PMID 11101529.

Hoffman DW, Query CC, Golden BL, White SW, Keene JD (March 1991). "RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (6): 2495–9. Bibcode:1991PNAS...88.2495H. doi: 10.1073/pnas.88.6.2495 . PMC 51259 . PMID 1826055.
Nelissen RL, Sillekens PT, Beijer RP, Geurts van Kessel AH, van Venrooij WJ (June 1991). "Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein". Gene. 102 (2): 189–96. doi:10.1016/0378-1119(91)90077-O. PMID 1831431.
Jessen TH, Oubridge C, Teo CH, Pritchard C, Nagai K (November 1991). "Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA". The EMBO Journal. 10 (11): 3447–56. doi:10.1002/j.1460-2075.1991.tb04909.x. PMC 453073 . PMID 1833186.
Nagai K, Oubridge C, Jessen TH, Li J, Evans PR (December 1990). "Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A". Nature. 348 (6301): 515–20. Bibcode:1990Natur.348..515N. doi:10.1038/348515a0. PMID 2147232. S2CID 4336326.
Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ (December 1987). "cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins". The EMBO Journal. 6 (12): 3841–8. doi:10.1002/j.1460-2075.1987.tb02721.x. PMC 553857 . PMID 2962859.
Oubridge C, Ito N, Evans PR, Teo CH, Nagai K (December 1994). "Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin". Nature. 372 (6505): 432–8. Bibcode:1994Natur.372..432O. doi:10.1038/372432a0. PMID 7984237. S2CID 9404488.
Howe PW, Nagai K, Neuhaus D, Varani G (August 1994). "NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein". The EMBO Journal. 13 (16): 3873–81. doi:10.1002/j.1460-2075.1994.tb06698.x. PMC 395300 . PMID 8070414.
Allain FH, Gubser CC, Howe PW, Nagai K, Neuhaus D, Varani G (April 1996). "Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation". Nature. 380 (6575): 646–50. Bibcode:1996Natur.380..646A. doi:10.1038/380646a0. PMID 8602269. S2CID 4265453.
Avis JM, Allain FH, Howe PW, Varani G, Nagai K, Neuhaus D (March 1996). "Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding". Journal of Molecular Biology. 257 (2): 398–411. doi:10.1006/jmbi.1996.0171. PMID 8609632.
Lu J, Hall KB (August 1997). "Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy". Biochemistry. 36 (34): 10393–405. doi:10.1021/bi9709811. PMID 9265619.
Allain FH, Howe PW, Neuhaus D, Varani G (September 1997). "Structural basis of the RNA-binding specificity of human U1A protein". The EMBO Journal. 16 (18): 5764–72. doi:10.1093/emboj/16.18.5764. PMC 1170207 . PMID 9312034.
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
Ferré-D'Amaré AR, Zhou K, Doudna JA (October 1998). "Crystal structure of a hepatitis delta virus ribozyme". Nature. 395 (6702): 567–74. Bibcode:1998Natur.395..567F. doi:10.1038/26912. PMID 9783582. S2CID 4359811.
Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC (December 1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor". RNA. 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC 1369720 . PMID 9848648.
Hetzer M, Mattaj IW (January 2000). "An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins". The Journal of Cell Biology. 148 (2): 293–303. doi:10.1083/jcb.148.2.293. PMC 2174293 . PMID 10648562.
Klein Gunnewiek JM, Hussein RI, van Aarssen Y, Palacios D, de Jong R, van Venrooij WJ, Gunderson SI (March 2000). "Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation". Molecular and Cellular Biology. 20 (6): 2209–17. doi:10.1128/MCB.20.6.2209-2217.2000. PMC 110837 . PMID 10688667.
Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G (April 2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein". Nature Structural Biology. 7 (4): 329–35. doi:10.1038/74101. PMID 10742179. S2CID 13432764.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846 . PMID 11101529.
Simmons A, Aluvihare V, McMichael A (June 2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators". Immunity. 14 (6): 763–77. doi: 10.1016/S1074-7613(01)00158-3 . PMID 11420046.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000077312 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1701111-3] Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A (January 1991). "Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region". Cytogenetics and Cell Genetics. 54 (1–2): 15–9. doi:10.1159/000132946. PMID 1701111.

[entrez-4] "Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A".

[pmid11101529-5] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846 . PMID 11101529.

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v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

Small nuclear ribonucleoprotein polypeptide A

Contents

Interactions

Related Research Articles

References

Further reading