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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | MVP , LRP, VAULT1, major vault protein, lung resistance-related protein | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605088; MGI: 1925638; HomoloGene: 3752; GeneCards: MVP; OMA:MVP - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Major vault protein, also known as lung resistance-related protein is a protein that in humans is encoded by the MVP gene. [5] [6] 78 copies of the protein assemble into the large compartments called vaults.
This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. Major vault protein comprises 70% of vaults which also contain vPARP and TEP1. [7] This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [6]
Major vault protein coimmunoprecipitates with the human estrogen receptor and treatment with estradiol increases major vault protein associated with the estrogen receptor in nuclear extracts. [8]
Major vault protein has been shown to interact with estrogen receptor alpha, [9] PTEN [10] and PARP4. [11] [12]