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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MVP , LRP, VAULT1, major vault protein | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605088; MGI: 1925638; HomoloGene: 3752; GeneCards: MVP; OMA:MVP - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Major vault protein, also known as lung resistance-related protein is a protein that in humans is encoded by the MVP gene. [5] [6] 78 copies of the protein assemble into the large compartments called vaults.
This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. Major vault protein comprises 70% of vaults which also contain vPARP and TEP1. [7] This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [6]
Major vault protein coimmunoprecipitates with the human estrogen receptor and treatment with estradiol increases major vault protein associated with the estrogen receptor in nuclear extracts. [8]
Major vault protein has been shown to interact with estrogen receptor alpha, [9] PTEN [10] and PARP4. [11] [12]
P-glycoprotein 1 also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances.
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens. When produced by the Sertoli cells in the seminiferous tubules of the testis, it is called androgen-binding protein (ABP).
Multidrug resistance-associated protein 6 (MRP6) also known as ATP-binding cassette sub-family C member 6 (ABCC6) and multi-specific organic anion transporter E (MOAT-E) is a protein that in humans is encoded by the ABCC6 gene. The protein encoded by the ABCC6 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.
ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.
Many eukaryotic cells contain large ribonucleoprotein particles in the cytoplasm known as vaults. The vault complex comprises the major vault protein (MVP), two minor vault proteins, and a variety of small untranslated RNA molecules known as vault RNAs only found in higher eukaryotes. These molecules are transcribed by RNA polymerase III.
The ATP-binding cassette 4 (ABCB4) gene encodes multidrug resistance protein 3. ABCB4 is associated with progressive familial intrahepatic cholestasis type 3 and intrahepatic cholestasis of pregnancy.
Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene.
Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.
Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene.
Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.
Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.
Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.
Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.
ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene.
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.
The vault or vault cytoplasmic ribonucleoprotein is a eukaryotic organelle whose function is not yet fully understood. Discovered and isolated by Nancy Kedersha and Leonard Rome in 1986, vaults are cytoplasmic organelles which, when negative-stained and viewed under an electron microscope, resemble the arches of a cathedral's vaulted ceiling, with 39-fold symmetry. They are present in many types of eukaryotic cells, and appear to be highly conserved among eukaryotes.
Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.
Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies. In some cases, cancers can evolve resistance to multiple drugs, called multiple drug resistance.
Piet Borst CBE is emeritus professor of clinical biochemistry and molecular biology at the University of Amsterdam (UVA), and until 1999 director of research and chairman of the board of directors of the Netherlands Cancer Institute and the Antoni van Leeuwenhoekziekenhuis (NKI-AVL). He continued to work at the NKI-AVL as a staff member and group leader until 2016.
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