TEP1

TEP1
Identifiers
Aliases	TEP1 , TLP1, TP1, TROVE1, VAULT2, p240, telomerase associated protein 1
External IDs	OMIM: 601686; MGI: 109573; HomoloGene: 5157; GeneCards: TEP1; OMA:TEP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 20,365,667 bp [1] End 20,413,501 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 C1|14 26.26 cM Start 51,061,516 bp [2] End 51,108,017 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of transverse colon jejunal mucosa epithelium of colon rectum granulocyte duodenum spleen lymph node tonsil Top expressed in duodenum intestinal villus Ileal epithelium jejunum large intestine colon crypt of lieberkuhn of small intestine stroma of bone marrow Paneth cell lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding p53 binding nucleotide binding enzyme binding telomerase RNA binding telomerase activity RNA binding Cellular component telomere telomerase holoenzyme complex nucleus cytoplasm nuclear matrix chromosome U5 snRNP precatalytic spliceosome catalytic step 2 spliceosome ribonucleoprotein complex Biological process telomere maintenance via recombination RNA-dependent DNA biosynthetic process RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7011 21745 Ensembl ENSG00000129566 ENSMUSG00000006281 UniProt Q99973 P97499 RefSeq (mRNA) NM_007110 NM_001319035 NM_009351 RefSeq (protein) NP_001305964 NP_009041 NP_033377 Location (UCSC) Chr 14: 20.37 – 20.41 Mb Chr 14: 51.06 – 51.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Telomerase protein component 1 is a ncRNA binding protein that in humans is encoded by the TEP1 gene. ^{[5] [6]}

Function

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. ^[6] It is also a minor vault protein.

References

1. GRCh38: Ensembl release 89: ENSG00000129566 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006281 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (November 1997). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID   9403057.
6. "Entrez Gene: TEP1 telomerase-associated protein 1".

Further reading

• Joly EC, Tremblay E, Tanguay RM, Wu Y, Bibor-Hardy V (October 1994). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix". Journal of Cell Science. 107 ( Pt 10) (10): 2851–9. doi:10.1242/jcs.107.10.2851. PMID   7876352.
• Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO (February 1997). "A mammalian telomerase-associated protein". Science. 275 (5302): 973–7. doi:10.1126/science.275.5302.973. PMID   9020079. S2CID   21631570.
• Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO (December 1997). "Human telomerase contains evolutionarily conserved catalytic and structural subunits". Genes & Development. 11 (23): 3109–15. doi:10.1101/gad.11.23.3109. PMC   316744 . PMID   9389643.
• Li H, Zhao L, Yang Z, Funder JW, Liu JP (December 1998). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells". The Journal of Biological Chemistry. 273 (50): 33436–42. doi: 10.1074/jbc.273.50.33436 . PMID   9837921.
• Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (November 1999). "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry. 274 (46): 32712–7. doi: 10.1074/jbc.274.46.32712 . PMID   10551828.
• Li H, Cao Y, Berndt MC, Funder JW, Liu JP (November 1999). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene. 18 (48): 6785–94. doi: 10.1038/sj.onc.1203061 . PMID   10597287.
• Koyanagi Y, Kobayashi D, Yajima T, Asanuma K, Kimura T, Sato T, Kida T, Yagihashi A, Kameshima H, Watanabe N (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Research. 20 (2A): 773–8. PMID   10810353.
• Beattie TL, Zhou W, Robinson MO, Harrington L (October 2000). "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding". Molecular Biology of the Cell. 11 (10): 3329–40. doi:10.1091/mbc.11.10.3329. PMC   14995 . PMID   11029039.
• Zhang RG, Zhang RP, Wang XW, Xie H (March 2002). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Research. 12 (1): 55–62. doi: 10.1038/sj.cr.7290110 . PMID   11942411.
• Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ (July 2002). "Differential regulation of telomerase activity by six telomerase subunits". European Journal of Biochemistry. 269 (14): 3442–50. doi: 10.1046/j.1432-1033.2002.03025.x . PMID   12135483.
• Zhou JH, Zhang HM, Chen Q, Han DD, Pei F, Zhang LS, Yang DT (August 2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World Journal of Gastroenterology. 9 (8): 1808–14. doi: 10.3748/wjg.v9.i8.1808 . PMC   4611549 . PMID   12918126.
• Li C, Wu MY, Liang YR, Wu XY (November 2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World Journal of Gastroenterology. 9 (11): 2395–9. doi: 10.3748/wjg.v9.i11.2395 . PMC   4656508 . PMID   14606063.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.