SNRPB2

SNRPB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9N
Identifiers
Aliases	SNRPB2 , Msl1, U2B'', small nuclear ribonucleoprotein polypeptide B2
External IDs	OMIM: 603520; MGI: 104805; HomoloGene: 37728; GeneCards: SNRPB2; OMA:SNRPB2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p12.1 Start 16,729,961 bp [1] End 16,742,564 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 G1 Start 142,904,959 bp [2] End 142,914,773 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ganglionic eminence Achilles tendon monocyte epithelium of nasopharynx skin of hip appendix islet of Langerhans superficial temporal artery Top expressed in medial ganglionic eminence abdominal wall primitive streak maxillary prominence mandibular prominence dermis otic placode ventricular zone cumulus cell embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding snRNA stem-loop binding protein binding RNA binding snRNP binding U1 snRNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex U2 snRNP small nuclear ribonucleoprotein complex fibrillar center nucleoplasm nuclear speck U1 snRNP U2-type catalytic step 2 spliceosome nucleus U2-type precatalytic spliceosome Biological process mRNA processing RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6629 20639 Ensembl ENSG00000125870 ENSMUSG00000008333 UniProt P08579 Q9CQI7 RefSeq (mRNA) NM_198220 NM_003092 NM_021335 RefSeq (protein) NP_003083 NP_937863 NP_067310 Location (UCSC) Chr 20: 16.73 – 16.74 Mb Chr 2: 142.9 – 142.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene. ^{[5] [6]}

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125870 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008333 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A. 84 (8): 2421–5. Bibcode:1987PNAS...84.2421H. doi: 10.1073/pnas.84.8.2421 . PMC   304663 . PMID   2951739.
6. "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B".

Further reading

• Feeney RJ, Zieve GW (1990). "Nuclear exchange of the U1 and U2 snRNP-specific proteins". J. Cell Biol. 110 (4): 871–81. doi:10.1083/jcb.110.4.871. PMC   2116108 . PMID   2139037.
• Laitinen J, Saris P, Hölttä E, Pettersson I (1995). "U2-snRNP B" protein gene is an early growth-inducible gene". J. Cell. Biochem. 58 (4): 490–8. doi:10.1002/jcb.240580412. PMID   7593271. S2CID   24548645.
• Hong W, Bennett M, Xiao Y, et al. (1997). "Association of U2 snRNP with the spliceosomal complex E." Nucleic Acids Res. 25 (2): 354–61. doi:10.1093/nar/25.2.354. PMC   146436 . PMID   9016565.
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi: 10.1016/S0092-8674(00)80367-0 . PMID   9323129. S2CID   10855404.
• Moraitou M, Patrinou-Georgoula M, Guialis A (1998). "Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles". Biochem. J. 332 (1): 135–44. doi:10.1042/bj3320135. PMC   1219461 . PMID   9576861.
• Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. Bibcode:1998Natur.394..645P. doi:10.1038/29234. PMID   9716128. S2CID   204999419.
• Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID   9731529. S2CID   585778.
• Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Hum. Mol. Genet. 8 (13): 2351–7. doi: 10.1093/hmg/8.13.2351 . PMID   10556282.
• Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II". J. Cell Biol. 152 (1): 75–85. doi:10.1083/jcb.152.1.75. PMC   2193649 . PMID   11149922.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID   11780068. S2CID   1518837.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Chung S, Zhou Z, Huddleston KA, et al. (2002). "Crooked neck is a component of the human spliceosome and implicated in the splicing process". Biochim. Biophys. Acta. 1576 (3): 287–97. doi:10.1016/S0167-4781(02)00368-8. PMID   12084575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.