Small nuclear ribonucleoprotein D2

SNRPD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B34, 3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPD2 , SMD2, SNRPD1, Sm-D2, Small nuclear ribonucleoprotein D2, small nuclear ribonucleoprotein D2 polypeptide
External IDs	OMIM: 601061; MGI: 98345; HomoloGene: 3381; GeneCards: SNRPD2; OMA:SNRPD2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 45,687,460 bp [1] End 45,692,569 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A3 Start 18,883,647 bp [2] End 18,887,467 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell embryo corpus epididymis oral cavity left ovary ganglionic eminence tail of epididymis caput epididymis superficial temporal artery vulva Top expressed in yolk sac synovial joint urinary bladder ankle joint embryo ventricular zone embryo lens epiblast ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding U1 snRNP binding Cellular component cytoplasm SMN-Sm protein complex cytosol catalytic step 2 spliceosome U4/U6 x U5 tri-snRNP complex U5 snRNP U12-type spliceosomal complex U2 snRNP nucleoplasm methylosome precatalytic spliceosome small nuclear ribonucleoprotein complex pICln-Sm protein complex spliceosomal complex U4 snRNP extracellular exosome nucleus U1 snRNP U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome mRNA processing spliceosomal snRNP assembly spliceosomal complex assembly RNA splicing import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6633 107686 Ensembl ENSG00000125743 ENSMUSG00000040824 UniProt P62316 P62317 RefSeq (mRNA) NM_004597 NM_177542 NM_001369751 NM_001369752 NM_001384647 NM_026943 RefSeq (protein) NP_004588 NP_808210 NP_001356680 NP_001356681 NP_081219 Location (UCSC) Chr 19: 45.69 – 45.69 Mb Chr 7: 18.88 – 18.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. ^{[5] [6] [7]} It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. ^[7]

Interactions

Small nuclear ribonucleoprotein D2 has been shown to interact with DDX20, ^[8] Small nuclear ribonucleoprotein D1, ^{[9] [10]} Small nuclear ribonucleoprotein polypeptide F, ^[9] CDC5L ^[11] and SMN1. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000125743 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040824 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lehmeier T, Raker V, Hermann H, Luhrmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A. 91 (25): 12317–21. Bibcode:1994PNAS...9112317L. doi: 10.1073/pnas.91.25.12317 . PMC   45428 . PMID   7527560.
6. Lehmeier T, Foulaki K, Luhrmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC   332598 . PMID   1701240.
7. "Entrez Gene: SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa".
8. Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6). UNITED STATES: 1181–94. doi:10.1083/jcb.147.6.1181. ISSN   0021-9525. PMC   2168095 . PMID   10601333.
9. Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1). UNITED STATES: 63–9. doi:10.1006/excr.1997.3750. ISSN   0014-4827. PMID   9417867.
10. Kambach, C; Walke S; Young R; Avis J M; de la Fortelle E; Raker V A; Lührmann R; Li J; Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3). UNITED STATES: 375–87. doi: 10.1016/S0092-8674(00)80550-4 . ISSN   0092-8674. PMID   10025403. S2CID   17379935.
11. Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23). ENGLAND: 6569–81. doi:10.1093/emboj/19.23.6569. ISSN   0261-4189. PMC   305846 . PMID   11101529.
12. Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13). ENGLAND: 1977–86. doi: 10.1093/hmg/9.13.1977 . ISSN   0964-6906. PMID   10942426.

Further reading

• Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832–6. Bibcode:1988PNAS...85.4832R. doi: 10.1073/pnas.85.13.4832 . PMC   280530 . PMID   3260384.
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi: 10.1016/S0092-8674(00)80367-0 . PMID   9323129. S2CID   10855404.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID   9417867.
• Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi: 10.1016/S0092-8674(00)80550-4 . PMID   10025403. S2CID   17379935.
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC   2168095 . PMID   10601333.
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC   2174312 . PMID   10725331.
• Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi: 10.1093/hmg/9.13.1977 . PMID   10942426.
• Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.
• Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID   11135666. S2CID   27071310.
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC   140196 . PMID   11226169.
• Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi: 10.1074/jbc.M109448200 . PMID   11714716.
• Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi: 10.1074/jbc.M110141200 . PMID   11748230.
• Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi: 10.1074/jbc.M109984200 . PMID   11756452.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID   11780068. S2CID   1518837.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi: 10.1074/jbc.M203478200 . PMID   12065586.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Blagoev B, Kratchmarova I, Ong SE, et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID   12577067. S2CID   26838266.