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Rudolf Aebersold is a Swiss biologist, regarded as a pioneer in the fields of proteomics and systems biology. He has primarily researched techniques for measuring proteins in complex samples, in many cases via mass spectrometry. Ruedi Aebersold is a professor of Systems biology at the Institute of Molecular Systems Biology (IMSB) in ETH Zurich. He was one of the founders of the Institute for Systems Biology in Seattle, Washington, United States where he previously had a research group.
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Protein mass spectrometry refers to the application of mass spectrometry to the study of proteins. Mass spectrometry is an important method for the accurate mass determination and characterization of proteins, and a variety of methods and instrumentations have been developed for its many uses. Its applications include the identification of proteins and their post-translational modifications, the elucidation of protein complexes, their subunits and functional interactions, as well as the global measurement of proteins in proteomics. It can also be used to localize proteins to the various organelles, and determine the interactions between different proteins as well as with membrane lipids.
Quantitative proteomics is an analytical chemistry technique for determining the amount of proteins in a sample. The methods for protein identification are identical to those used in general proteomics, but include quantification as an additional dimension. Rather than just providing lists of proteins identified in a certain sample, quantitative proteomics yields information about the physiological differences between two biological samples. For example, this approach can be used to compare samples from healthy and diseased patients. Quantitative proteomics is mainly performed by two-dimensional gel electrophoresis (2-DE), preparative native PAGE, or mass spectrometry (MS). However, a recent developed method of quantitative dot blot (QDB) analysis is able to measure both the absolute and relative quantity of an individual proteins in the sample in high throughput format, thus open a new direction for proteomic research. In contrast to 2-DE, which requires MS for the downstream protein identification, MS technology can identify and quantify the changes.
Dame Carol Vivien Robinson, is a British chemist and former president of the Royal Society of Chemistry (2018–2020). She was a Royal Society Research Professor and is the Dr Lee's Professor of Physical and Theoretical Chemistry, and a professorial fellow at Exeter College, University of Oxford. She is the first director of the Kavli Institution for Nanoscience Discovery, University of Oxford, and she was previously professor of mass spectrometry at the chemistry department of the University of Cambridge.
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The Centre for Gene Regulation and Expression, located within the School of Life Sciences, University of Dundee, is a research facility working in the field of gene expression and chromosome biology. Previously part of the Dundee Biocentre and receiving significant Wellcome Trust funding from 1995 onwards, it was awarded Wellcome Trust Centre status in 2008. Professor Tom Owen-Hughes is the centre's director.
Albert J.R. Heck is a Dutch scientist and professor at Utrecht University, the Netherlands in the field of mass spectrometry and proteomics. He is known for his work on technologies to study proteins in their natural environment, with the aim to understand their biological function. Albert Heck was awarded the Spinoza Prize in 2017, the highest scientific award in the Netherlands.
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Peter Nemes is a Hungarian-American chemist, who is active in the fields of bioanalytical chemistry, mass spectrometry, cell/developmental biology, neuroscience, and biochemistry.
Vicki Wysocki is an American scientist. She is a professor and an Ohio Eminent Scholar at Ohio State University, and also the director of the Campus Chemical Instrument Center.
Claire Eyers is a British biological mass spectrometrist who is professor of biological mass spectrometry at the University of Liverpool, where she heads up the Centre for Proteome Research. Her research publications list her either as Claire E Haydon or Claire E Eyers.
Ying Ge is a Chinese-American chemist who is a Professor of Cell and Regenerative Biology at the University of Wisconsin–Madison. Her research considers the molecular mechanisms that underpin cardiac disease. She has previously served on the board of directors of the American Society for Mass Spectrometry. In 2020 Ge was named on the Analytical Scientist Power List.
Catherine E. Costello is the William Fairfield Warren distinguished professor in the department of biochemistry, Cell Biology and Genomics, and the director of the Center for Biomedical Mass Spectrometry at the Boston University School of Medicine.
Helen Jill Cooper is a British chemist who is Professor of mass spectrometry at the University of Birmingham. She serves as Deputy Head of the School of Chemistry and holds an Engineering and Physical Sciences Research Council Established Career Fellowship. Her research considers the development of native ambient mass spectrometry to enable direct analysis of intact proteins and protein assemblies from tissue.
Paola Picotti is an Italian biologist who is Professor for Molecular Systems Biology at ETH Zürich. She is Deputy Head of the Institute for Molecular Systems Biology. Her research investigates how the conformational changes of proteins impact cellular networks. She was awarded the 2020 ETH Zürich Rössler Prize and the 2019 EMBO Gold Medal.
References
- ↑ Rappsilber, Juri. Proteomanalyse an Multiproteinkomplexen durch Massenspektrometrie, Bioinformatik und Molekularbiologie (Thesis). Goethe University Frankfurt. Retrieved 6 December 2021.
- ↑ "Wellcome Centre for Cell Biology, Rappsilber lab". WCCB. 2 February 2023. Retrieved 17 December 2023.
- ↑ "Wellcome Senior Research Fellow". Wellcome Centre for Cell Biology. Retrieved 6 December 2021.
- ↑ "Einstein Professors: Juri Rappsilber". Einstein Foundation Berlin . Retrieved 6 December 2021.
- ↑ "The Rappsilber Laboratory analyses the structure and interaction of proteins in their natural environment". TU Berlin. Retrieved 6 December 2021.
- ↑ "Research: Overview". Rappsilber Laboratory. Retrieved 6 December 2021.
- ↑ "List of ERC Synergy Grants 2023" (PDF). Retrieved 17 December 2023.
- ↑ "Juri Rappsilber receives the highest level of funding from the European Research Council (ERC)". TU Berlin. Retrieved 30 January 2024.
- ↑ "TU Berlin Teaching Awards 2023" . Retrieved 17 December 2023.
- ↑ "DGMS Life Sciences Awards" . Retrieved 17 December 2023.
- ↑ "Juri Rappsilber". European Molecular Biology Organization (EMBO). Retrieved 6 December 2021.
- ↑ "EuPA Awards" . Retrieved 17 December 2023.
- ↑ "Multi-user Equipment Grants". Wellcome Trust. Retrieved 6 December 2021.
- ↑ "Senior Research Fellowships". Wellcome Trust. Retrieved 6 December 2021.
