CDC25B

Last updated
CDC25B
Protein CDC25B PDB 1cwr.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDC25B , cell division cycle 25B
External IDs OMIM: 116949 MGI: 99701 HomoloGene: 41451 GeneCards: CDC25B
Orthologs
SpeciesHumanMouse
Entrez

994

12531

Ensembl

ENSG00000101224

ENSMUSG00000027330

UniProt

P30305

P30306

RefSeq (mRNA)

NM_001111075
NM_023117

RefSeq (protein)

NP_001104545
NP_075606

Location (UCSC) Chr 20: 3.79 – 3.81 Mb Chr 2: 131.03 – 131.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene. [5]

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [6]

Interactions

CDC25B has been shown to interact with MAPK14, [7] Casein kinase 2, alpha 1, [8] CHEK1, [9] MELK, [10] Estrogen receptor alpha, [11] YWHAB, [12] [13] YWHAZ, [12] YWHAH [12] and YWHAE. [12] [13]

Related Research Articles

G<sub>2</sub> phase Second growth phase in the eukaryotic cell cycle, prior to mitosis

G2 phase, Gap 2 phase, or Growth 2 phase, is the third subphase of interphase in the cell cycle directly preceding mitosis. It follows the successful completion of S phase, during which the cell’s DNA is replicated. G2 phase ends with the onset of prophase, the first phase of mitosis in which the cell’s chromatin condenses into chromosomes.

Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant. As with other cell cycle proteins or genes such as Cdc2 and Cdc4, the "cdc" in its name refers to "cell division control". Dual-specificity phosphatases are considered a sub-class of protein tyrosine phosphatases. By removing inhibitory phosphate residues from target cyclin-dependent kinases (Cdks), Cdc25 proteins control entry into and progression through various phases of the cell cycle, including mitosis and S ("Synthesis") phase.

<span class="mw-page-title-main">CHEK2</span> Protein-coding gene in humans

CHEK2 is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.

<span class="mw-page-title-main">Cyclin-dependent kinase 1</span> Mammalian protein found in Homo sapiens

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates ; phosphorylation of these proteins leads to cell cycle progression.

<span class="mw-page-title-main">Cyclin B1</span> Protein-coding gene in the species Homo sapiens

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene.

<span class="mw-page-title-main">CDC25A</span> Protein-coding gene in the species Homo sapiens

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

<span class="mw-page-title-main">Wee1-like protein kinase</span> Protein-coding gene in the species Homo sapiens

WEE1 homolog , also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.

<span class="mw-page-title-main">Cyclin A1</span> Protein-coding gene in the species Homo sapiens

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.

<span class="mw-page-title-main">YWHAB</span> Protein-coding gene in the species Homo sapiens

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.

<span class="mw-page-title-main">CDC25C</span> Protein-coding gene in the species Homo sapiens

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.

<span class="mw-page-title-main">YWHAE</span> Protein-coding gene in the species Homo sapiens

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.

<span class="mw-page-title-main">GADD45A</span> Protein-coding gene in the species Homo sapiens

Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.

<span class="mw-page-title-main">PPP2R4</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

<span class="mw-page-title-main">PLK3</span> Protein-coding gene in the species Homo sapiens

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

<span class="mw-page-title-main">CDKN2C</span> Protein-coding gene in the species Homo sapiens

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.

<span class="mw-page-title-main">CDKN2D</span> Protein-coding gene in the species Homo sapiens

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

<span class="mw-page-title-main">CCNG1</span> Protein-coding gene in the species Homo sapiens

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.

<span class="mw-page-title-main">Cyclin-dependent kinase 3</span> Protein-coding gene in the species Homo sapiens

Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene.

<span class="mw-page-title-main">MELK</span> Protein-coding gene in the species Homo sapiens

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.

<span class="mw-page-title-main">Wee1</span> Nuclear protein

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe. Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101224 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027330 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Galaktionov K, Beach D (February 1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID   1836978. S2CID   9659637.
  6. ↑ "Entrez Gene: CDC25B cell division cycle 25 homolog B (S. pombe)".
  7. ↑ Bulavin DV, Higashimoto Y, Popoff I J, Gaarde W A, Basrur V, Potapova O, Appella E, Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature . 411 (6833): 102–7. doi:10.1038/35075107. ISSN   0028-0836. PMID   11333986. S2CID   4410763.
  8. ↑ Theis-Febvre N, Filhol Odile, Froment Carine, Cazales Martine, Cochet Claude, Monsarrat Bernard, Ducommun Bernard, Baldin Véronique (January 2003). "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene. 22 (2): 220–32. doi:10.1038/sj.onc.1206107. ISSN   0950-9232. PMID   12527891. S2CID   11296989.
  9. ↑ Sanchez Y, Wong C, Thoma R S, Richman R, Wu Z, Piwnica-Worms H, Elledge S J (September 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science . 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN   0036-8075. PMID   9278511.
  10. ↑ Davezac N, Baldin Véronique, Blot Joëlle, Ducommun Bernard, Tassan Jean-Pierre (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. ISSN   0950-9232. PMID   12400006. S2CID   20678893.
  11. ↑ Ma ZQ, Liu Z, Ngan E S, Tsai S Y (December 2001). "Cdc25B Functions as a Novel Coactivator for the Steroid Receptors". Mol. Cell. Biol. 21 (23): 8056–67. doi:10.1128/MCB.21.23.8056-8067.2001. ISSN   0270-7306. PMC   99972 . PMID   11689696.
  12. 1 2 3 4 Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN   0950-9232. PMID   10713667. S2CID   5816838.
  13. 1 2 Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. Bibcode:1995PNAS...92.7892C. doi: 10.1073/pnas.92.17.7892 . ISSN   0027-8424. PMC   41252 . PMID   7644510.

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