CDC25B

CDC25B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CWR, 1CWS, 1CWT, 1QB0, 1YM9, 1YMD, 1YMK, 1YML, 1YS0, 2A2K, 2IFD, 2IFV, 2UZQ, 3FQT, 3FQU, 4WH7, 4WH9
Identifiers
Aliases	CDC25B , cell division cycle 25B
External IDs	OMIM: 116949; MGI: 99701; HomoloGene: 41451; GeneCards: CDC25B; OMA:CDC25B - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 3,786,772 bp [1] End 3,806,121 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 F1|2 63.29 cM Start 131,028,869 bp [2] End 131,040,417 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right lung right hemisphere of cerebellum gastric mucosa upper lobe of left lung oocyte stromal cell of endometrium secondary oocyte lymph node anterior pituitary Top expressed in fetal liver hematopoietic progenitor cell blood tibiofemoral joint ventricular zone lip human fetus spleen thymus granulocyte zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein tyrosine phosphatase activity hydrolase activity protein kinase binding phosphoprotein phosphatase activity Cellular component cytosol centrosome spindle pole intracellular anatomical structure microtubule organizing center cytoskeleton nucleus nucleoplasm cytoplasm Biological process protein dephosphorylation positive regulation of mitotic cell cycle cell division positive regulation of cytokinesis protein phosphorylation G2/M transition of mitotic cell cycle oocyte maturation positive regulation of cell population proliferation cell cycle female meiosis I positive regulation of protein kinase activity peptidyl-tyrosine dephosphorylation positive regulation of cell cycle G2/M phase transition mitotic cell cycle positive regulation of G2/M transition of mitotic cell cycle positive regulation of G2/MI transition of meiotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 994 12531 Ensembl ENSG00000101224 ENSMUSG00000027330 UniProt P30305 P30306 RefSeq (mRNA) NM_001287516 NM_001287517 NM_001287518 NM_001287519 NM_001287520 NM_001287522 NM_001287524 NM_004358 NM_021872 NM_021873 NM_021874 NM_212530 NM_001111075 NM_023117 RefSeq (protein) NP_001274445 NP_001274446 NP_001274447 NP_001274448 NP_001274449 NP_001274451 NP_001274453 NP_004349 NP_068658 NP_068659 NP_001104545 NP_075606 Location (UCSC) Chr 20: 3.79 – 3.81 Mb Chr 2: 131.03 – 131.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene. ^[5]

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. ^[6]

Interactions

CDC25B has been shown to interact with MAPK14, ^[7] Casein kinase 2, alpha 1, ^[8] CHEK1, ^[9] MELK, ^[10] Estrogen receptor alpha, ^[11] YWHAB, ^{[12] [13]} YWHAZ, ^[12] YWHAH ^[12] and YWHAE. ^{[12] [13]}

References

1. GRCh38: Ensembl release 89: ENSG00000101224 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027330 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Galaktionov K, Beach D (February 1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID   1836978. S2CID   9659637.
6. "Entrez Gene: CDC25B cell division cycle 25 homolog B (S. pombe)".
7. Bulavin DV, Higashimoto Y, Popoff I J, Gaarde W A, Basrur V, Potapova O, Appella E, Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature . 411 (6833): 102–7. Bibcode:2001Natur.411..102B. doi:10.1038/35075107. ISSN   0028-0836. PMID   11333986. S2CID   4410763.
8. Theis-Febvre N, Filhol Odile, Froment Carine, Cazales Martine, Cochet Claude, Monsarrat Bernard, Ducommun Bernard, Baldin Véronique (January 2003). "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene. 22 (2): 220–32. doi:10.1038/sj.onc.1206107. ISSN   0950-9232. PMID   12527891. S2CID   11296989.
9. Sanchez Y, Wong C, Thoma R S, Richman R, Wu Z, Piwnica-Worms H, Elledge S J (September 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science . 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN   0036-8075. PMID   9278511.
10. Davezac N, Baldin Véronique, Blot Joëlle, Ducommun Bernard, Tassan Jean-Pierre (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. ISSN   0950-9232. PMID   12400006. S2CID   20678893.
11. Ma ZQ, Liu Z, Ngan E S, Tsai S Y (December 2001). "Cdc25B Functions as a Novel Coactivator for the Steroid Receptors". Mol. Cell. Biol. 21 (23): 8056–67. doi:10.1128/MCB.21.23.8056-8067.2001. ISSN   0270-7306. PMC   99972 . PMID   11689696.
12. Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN   0950-9232. PMID   10713667. S2CID   5816838.
13. Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. Bibcode:1995PNAS...92.7892C. doi: 10.1073/pnas.92.17.7892 . ISSN   0027-8424. PMC   41252 . PMID   7644510.

Further reading

• Draetta G, Eckstein J (1997). "Cdc25 protein phosphatases in cell proliferation". Biochim. Biophys. Acta. 1332 (2): M53–63. doi:10.1016/S0304-419X(96)00049-2. PMID   9141461.
• Nilsson I, Hoffmann I (2000). "Cell cycle regulation by the Cdc25 phosphatase family". Progress in Cell Cycle Research. Vol. 4. pp. 107–14. doi:10.1007/978-1-4615-4253-7_10. ISBN   978-1-4613-6909-7. PMID   10740819.
• Nagata A, Igarashi M, Jinno S, et al. (1992). "An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells". New Biol. 3 (10): 959–68. PMID   1662986.
• Conklin DS, Galaktionov K, Beach D (1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. Bibcode:1995PNAS...92.7892C. doi: 10.1073/pnas.92.17.7892 . PMC   41252 . PMID   7644510.
• Galaktionov K, Lee AK, Eckstein J, et al. (1995). "CDC25 phosphatases as potential human oncogenes". Science. 269 (5230): 1575–7. Bibcode:1995Sci...269.1575G. doi:10.1126/science.7667636. PMID   7667636.
• Demetrick DJ, Beach DH (1994). "Chromosome mapping of human CDC25A and CDC25B phosphatases". Genomics. 18 (1): 144–7. doi:10.1006/geno.1993.1440. PMID   8276402.
• Honda R, Ohba Y, Nagata A, et al. (1993). "Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase". FEBS Lett. 318 (3): 331–4. Bibcode:1993FEBSL.318..331H. doi: 10.1016/0014-5793(93)80540-B . PMID   8440392. S2CID   30754963.
• Lane SA, Baker E, Sutherland GR, et al. (1993). "The human cell cycle gene CDC25B is located at 20p13". Genomics. 15 (3): 693–4. doi:10.1006/geno.1993.1129. PMID   8468065.
• Baldin V, Cans C, Superti-Furga G, Ducommun B (1997). "Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?". Oncogene. 14 (20): 2485–95. doi:10.1038/sj.onc.1201063. PMID   9188863. S2CID   6164215.
• Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. doi: 10.1074/jbc.272.35.22300 . PMID   9268380.
• Sanchez Y, Wong C, Thoma RS, et al. (1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. PMID   9278511.
• Jin P, Hardy S, Morgan DO (1998). "Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage". J. Cell Biol. 141 (4): 875–85. doi:10.1083/jcb.141.4.875. PMC   2132764 . PMID   9585407.
• Hofmann K, Bucher P, Kajava AV (1998). "A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain". J. Mol. Biol. 282 (1): 195–208. doi:10.1006/jmbi.1998.1998. PMID   9733650.
• Forrest AR, McCormack AK, DeSouza CP, et al. (1999). "Multiple splicing variants of cdc25B regulate G2/M progression". Biochem. Biophys. Res. Commun. 260 (2): 510–5. Bibcode:1999BBRC..260..510F. doi:10.1006/bbrc.1999.0870. PMID   10403798.
• Karlsson C, Katich S, Hagting A, et al. (1999). "Cdc25b and Cdc25c Differ Markedly in Their Properties as Initiators of Mitosis". J. Cell Biol. 146 (3): 573–84. doi:10.1083/jcb.146.3.573. PMC   2150562 . PMID   10444066.
• Reynolds RA, Yem AW, Wolfe CL, et al. (1999). "Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle". J. Mol. Biol. 293 (3): 559–68. doi:10.1006/jmbi.1999.3168. PMID   10543950.
• Mils V, Baldin V, Goubin F, et al. (2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. PMID   10713667. S2CID   5816838.

External links

• Human CDC25B genome location and CDC25B gene details page in the UCSC Genome Browser .