PTP4A1

Last updated
PTP4A1
Protein PTP4A1 PDB 1rxd.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTP4A1 , HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1, protein tyrosine phosphatase type IVA, member 1, protein tyrosine phosphatase 4A1
External IDs OMIM: 601585; MGI: 1277096; HomoloGene: 2587; GeneCards: PTP4A1; OMA:PTP4A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003463

NM_011200

RefSeq (protein)

NP_003454

NP_035330

Location (UCSC) Chr 6: 63.52 – 63.58 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene. [4] [5]

Contents

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. [5]

Interactions

PTP4A1 has been shown to interact with ATF7. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112245 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Peng Y, Genin A, Spinner NB, Diamond RH, Taub R (Aug 1998). "The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer". J Biol Chem. 273 (27): 17286–95. doi: 10.1074/jbc.273.27.17286 . PMID   9642300.
  5. 1 2 "Entrez Gene: PTP4A1 protein tyrosine phosphatase type IVA, member 1".
  6. Peters, C S; Liang X; Li S; Kannan S; Peng Y; Taub R; Diamond R H (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. 276 (17). United States: 13718–26. doi: 10.1074/jbc.M011562200 . ISSN   0021-9258. PMID   11278933.

Further reading