PTPRR

PTPRR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A8B
Identifiers
Aliases	PTPRR , EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R, protein tyrosine phosphatase receptor type R
External IDs	OMIM: 602853; MGI: 109559; HomoloGene: 2135; GeneCards: PTPRR; OMA:PTPRR - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q15 Start 70,638,073 bp [1] End 70,920,738 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D2 Start 115,854,118 bp [2] End 116,110,837 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell right hemisphere of cerebellum prefrontal cortex entorhinal cortex jejunal mucosa mucosa of transverse colon Brodmann area 46 testicle orbitofrontal cortex cerebellar vermis Top expressed in Ileal epithelium zygote secondary oocyte entorhinal cortex perirhinal cortex lobe of cerebellum CA3 field jejunum transitional epithelium of urinary bladder lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein kinase binding hydrolase activity Cellular component integral component of membrane membrane plasma membrane cell junction perinuclear region of cytoplasm extracellular space cytoplasm cytosol Biological process protein dephosphorylation in utero embryonic development ERBB2 signaling pathway regulation of homophilic cell adhesion negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine dephosphorylation negative regulation of epithelial cell migration dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5801 19279 Ensembl ENSG00000153233 ENSMUSG00000020151 UniProt Q15256 Q62132 RefSeq (mRNA) NM_001207015 NM_001207016 NM_002849 NM_130846 NM_001161837 NM_001161838 NM_001161839 NM_001161840 NM_011217 NM_001358484 RefSeq (protein) NP_001193944 NP_001193945 NP_002840 NP_570897 NP_001155309 NP_001155310 NP_001155311 NP_001155312 NP_035347 NP_001345413 Location (UCSC) Chr 12: 70.64 – 70.92 Mb Chr 10: 115.85 – 116.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominantly expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation. ^[7]

Interactions

PTPRR has been shown to interact with MAPK7. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000153233 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020151 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H (Nov 1995). "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase". Gene. 162 (2): 279–84. doi:10.1016/0378-1119(95)00306-Q. PMID   7557444.
6. van den Maagdenberg AM, Schepens JT, Schepens MT, Merkx GF, Darroudi F, Wieringa B, Geurts van Kessel A, Hendriks WJ (Jul 1999). "Assignment1 of the PTP-SL/PTPBR7 gene (Ptprr/PTPRR) to mouse chromosome region 8A2 by in situ hybridization". Cytogenet Cell Genet. 84 (3–4): 243–4. doi:10.1159/000015268. PMID   10393441. S2CID   35964382.
7. "Entrez Gene: PTPRR protein tyrosine phosphatase, receptor type, R".
8. Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (Aug 2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33): 29503–9. doi: 10.1074/jbc.M202149200 . PMID   12042304.

Further reading

• Sharma E, Lombroso PJ (1995). "A neuronal protein tyrosine phosphatase induced by nerve growth factor". J. Biol. Chem. 270 (1): 49–53. doi: 10.1074/jbc.270.1.49 . PMID   7814416.
• Ogata M, Sawada M, Fujino Y, Hamaoka T (1995). "cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain". J. Biol. Chem. 270 (5): 2337–43. doi: 10.1074/jbc.270.5.2337 . PMID   7836467.
• Pulido R, Zúñiga A, Ullrich A (1999). "PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif". EMBO J. 17 (24): 7337–50. doi:10.1093/emboj/17.24.7337. PMC   1171079 . PMID   9857190.
• Ogata M, Oh-hora M, Kosugi A, Hamaoka T (1999). "Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7". Biochem. Biophys. Res. Commun. 256 (1): 52–6. doi:10.1006/bbrc.1999.0278. PMID   10066421.
• Zúñiga A, Torres J, Ubeda J, Pulido R (1999). "Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm". J. Biol. Chem. 274 (31): 21900–7. doi: 10.1074/jbc.274.31.21900 . hdl: 10550/84237 . PMID   10419510.
• Blanco-Aparicio C, Torres J, Pulido R (2000). "A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase". J. Cell Biol. 147 (6): 1129–36. doi:10.1083/jcb.147.6.1129. PMC   2168101 . PMID   10601328.
• Augustine KA, Silbiger SM, Bucay N, Ulias L, Boynton A, Trebasky LD, Medlock ES (2000). "Protein tyrosine phosphatase (PC12, Br7,S1) family: expression characterization in the adult human and mouse". Anat. Rec. 258 (3): 221–34. doi: 10.1002/(SICI)1097-0185(20000301)258:3<221::AID-AR1>3.0.CO;2-W . PMID   10705342.
• Bektas A, Hughes JN, Warram JH, Krolewski AS, Doria A (2001). "Type 2 diabetes locus on 12q15. Further mapping and mutation screening of two candidate genes". Diabetes. 50 (1): 204–8. doi: 10.2337/diabetes.50.1.204 . PMID   11147789.
• Szedlacsek SE, Aricescu AR, Fulga TA, Renault L, Scheidig AJ (2001). "Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation". J. Mol. Biol. 311 (3): 557–68. doi:10.1006/jmbi.2001.4890. PMID   11493009.
• Buschbeck M, Eickhoff J, Sommer MN, Ullrich A (2002). "Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway". J. Biol. Chem. 277 (33): 29503–9. doi: 10.1074/jbc.M202149200 . PMID   12042304.
• Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi: 10.1074/jbc.M210455200 . PMID   12493773.
• Tárrega C, Ríos P, Cejudo-Marín R, Blanco-Aparicio C, van den Berk L, Schepens J, Hendriks W, Tabernero L, Pulido R (2006). "ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1". J. Biol. Chem. 280 (45): 37885–94. doi: 10.1074/jbc.M504366200 . hdl: 2066/48764 . PMID   16148006.
• Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ (2006). "Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases". Biochem. J. 395 (3): 483–91. doi:10.1042/BJ20051931. PMC   1462698 . PMID   16441242.