DUSP12 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | DUSP12 , DUSP1, YVH1, dual specificity phosphatase 12 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604835 MGI: 1890614 HomoloGene: 5238 GeneCards: DUSP12 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene. [5] [6]
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [6]
Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.
Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene.
Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.
Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.
Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.
Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.
Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.
Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.
Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.
Fyn-related kinase is an enzyme that in humans is encoded by the FRK gene.
Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.
Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.
Serine/threonine-protein kinase, Intestinal cell kinase or ICK is an enzyme that in humans is encoded by the ICK gene.
Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.
Dual specificity phosphatase 13 is an enzyme that in humans is encoded by the DUSP13 gene.
Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme, in particular a dual-specificity kinase, that in humans is encoded by the DYRK2 gene.
Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.
Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene.
Dual specificity protein phosphatase 23, also known as low molecular mass dual specificity phosphatase 3 (LDP-3), is an enzyme that in humans is encoded by the DUSP23 gene.