SSH1

SSH1
Identifiers
Aliases	SSH1 , SSH1L, slingshot protein phosphatase 1
External IDs	OMIM: 606778 MGI: 2686240 HomoloGene: 41299 GeneCards: SSH1
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.11 Start 108,778,191 bp [1] End 108,857,590 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 114,075,155 bp [2] End 114,131,955 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium saphenous vein secondary oocyte trigeminal ganglion lower lobe of lung lactiferous duct spinal ganglia caput epididymis tibialis anterior muscle Top expressed in internal carotid artery external carotid artery sciatic nerve substantia nigra fossa blood ciliary body cumulus cell ascending aorta medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity actin binding hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cell projection plasma membrane midbody cleavage furrow cytoskeleton lamellipodium cytosol growth cone cell leading edge membrane integral component of membrane Biological process regulation of lamellipodium assembly protein dephosphorylation regulation of axonogenesis regulation of actin polymerization or depolymerization cell morphogenesis regulation of cellular protein metabolic process peptidyl-tyrosine dephosphorylation cellular response to ATP actin cytoskeleton organization dephosphorylation positive regulation of synaptic plasticity excitatory chemical synaptic transmission positive regulation of neuron death positive regulation of AMPA glutamate receptor clustering positive regulation of vascular associated smooth muscle cell migration positive regulation of excitatory postsynaptic potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54434 231637 Ensembl ENSG00000084112 ENSMUSG00000042121 UniProt Q8WYL5 Q76I79 RefSeq (mRNA) NM_001161330 NM_001161331 NM_018984 NM_198109 NM_001363469 RefSeq (protein) NP_001154802 NP_001154803 NP_061857 NP_932777 NP_001350398 Location (UCSC) Chr 12: 108.78 – 108.86 Mb Chr 5: 114.08 – 114.13 Mb PubMed search [3] [4]
Wikidata
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For the SSH-1 protocol, see Secure Shell#Version 1

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene. ^{[5] [6] [7]}

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000084112 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042121 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
6. Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi: 10.1016/S0092-8674(01)00638-9 . PMID   11832213. S2CID   5576208.
7. "Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Endo M, Ohashi K, Sasaki Y, et al. (2003). "Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin". J. Neurosci. 23 (7): 2527–37. doi: 10.1523/JNEUROSCI.23-07-02527.2003 . PMC   6742113 . PMID   12684437.
• Kaji N, Ohashi K, Shuin M, et al. (2003). "Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells". J. Biol. Chem. 278 (35): 33450–5. doi: 10.1074/jbc.M305802200 . PMID   12807904.
• Ohta Y, Kousaka K, Nagata-Ohashi K, et al. (2004). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes Cells. 8 (10): 811–24. doi: 10.1046/j.1365-2443.2003.00678.x . PMID   14531860. S2CID   24247372.
• Nishita M, Wang Y, Tomizawa C, et al. (2004). "Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion". J. Biol. Chem. 279 (8): 7193–8. doi: 10.1074/jbc.M312591200 . PMID   14645219.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dai S, Sarmiere PD, Wiggan O, et al. (2004). "Efficient Salmonella entry requires activity cycles of host ADF and cofilin". Cell. Microbiol. 6 (5): 459–71. doi: 10.1111/j.1462-5822.2004.00375.x . PMID   15056216. S2CID   20238982.
• Nagata-Ohashi K, Ohta Y, Goto K, et al. (2004). "A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia". J. Cell Biol. 165 (4): 465–71. doi:10.1083/jcb.200401136. PMC   2172350 . PMID   15159416.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Zhang Z, Niu Z, Yuan W, et al. (2005). "Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis". Hum. Mutat. 24 (5): 438. doi: 10.1002/humu.9283 . PMID   15459975. S2CID   22946257.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Soosairajah J, Maiti S, Wiggan O, et al. (2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". EMBO J. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC   548651 . PMID   15660133.
• Wang Y, Shibasaki F, Mizuno K (2005). "Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin". J. Biol. Chem. 280 (13): 12683–9. doi: 10.1074/jbc.M411494200 . PMID   15671020.
• Nishita M, Tomizawa C, Yamamoto M, et al. (2006). "Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration". J. Cell Biol. 171 (2): 349–59. doi:10.1083/jcb.200504029. PMC   2171197 . PMID   16230460.
• Yamamoto M, Nagata-Ohashi K, Ohta Y, et al. (2006). "Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L". FEBS Lett. 580 (7): 1789–94. doi: 10.1016/j.febslet.2006.02.034 . PMID   16513117. S2CID   27347823.
• Cai L, Marshall TW, Uetrecht AC, et al. (2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915–29. doi:10.1016/j.cell.2007.01.031. PMC   2630706 . PMID   17350576.
• Kligys K, Claiborne JN, DeBiase PJ, et al. (2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". J. Biol. Chem. 282 (44): 32520–8. doi: 10.1074/jbc.M707041200 . PMC   2754063 . PMID   17848544.