PTPRF

PTPRF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LAR, 2DJU, 2EDX, 2EDY, 2YD5, 2YD8, 4N5U, 2DN7
Identifiers
Aliases	PTPRF , LAR, BNAH2, protein tyrosine phosphatase, receptor type F, protein tyrosine phosphatase receptor type F
External IDs	OMIM: 179590 MGI: 102695 HomoloGene: 20623 GeneCards: PTPRF
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,623,666 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	118,291,405 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; nipple; ; parotid gland; ; hair follicle; ; germinal epithelium; ; jejunal mucosa; ; vulva; ; human penis; ; corpus epididymis; ; lactiferous duct;
	Top expressed in
	medullary collecting duct; ; hair follicle; ; external carotid artery; ; conjunctival fornix; ; left lung; ; left lung lobe; ; internal carotid artery; ; renal corpuscle; ; trigeminal ganglion; ; right lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	chondroitin sulfate proteoglycan binding ; heparin binding ; phosphoprotein phosphatase activity ; phosphatase activity ; protein-containing complex binding ; protein tyrosine phosphatase activity ; transmembrane receptor protein tyrosine phosphatase activity ; hydrolase activity ; cell adhesion molecule binding ;
Cellular component	integral component of membrane ; membrane ; integral component of plasma membrane ; neuronal cell body ; neuron projection ; extracellular exosome ; plasma membrane ;
Biological process	neuron projection regeneration ; regulation of axon regeneration ; negative regulation of receptor binding ; regulation of neuron projection development ; protein dephosphorylation ; transmembrane receptor protein tyrosine phosphatase signaling pathway ; cell adhesion ; peptidyl-tyrosine dephosphorylation ; cell migration ; dephosphorylation ; synaptic membrane adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	5792
	19268
	ENSG00000142949
	ENSMUSG00000033295
	P10586
	A2A8L5
NM_002840 ; NM_130440 ; NM_001329137 ; NM_001329138 ; NM_001329139 ;
	NM_001329140
	NM_011213
NP_001316066 ; NP_001316067 ; NP_001316068 ; NP_001316069 ; NP_002831 ;
	NP_569707
	NP_035343
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 11, 2023

Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene.^[5]^[6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig-like domains similar to those of the neural cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.^[6]

Interactions

PTPRF has been shown to interact with Beta-catenin ^[7]^[8] and liprin-alpha-1.^[9]^[10]^[11]

Related Research Articles

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene.

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.

Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene.

Receptor-type tyrosine-protein phosphatase PCP-2, is an enzyme that in humans is encoded by the PTPRU gene.

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.

Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the PTPRD gene.

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.

Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene. PTPRK is also known as PTPkappa and PTPκ.

Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) also known as islet cell autoantigen-related protein (ICAAR) and phogrin is an enzyme that in humans is encoded by the PTPRN2 gene. PTPRN and PTPRN2 are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142949 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033295 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Harder KW, Saw J, Miki N, Jirik F (Nov 1995). "Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line". Genomics. 27 (3): 552–3. doi:10.1006/geno.1995.1092. PMID 7558042.
1 2 "Entrez Gene: PTPRF protein tyrosine phosphatase, receptor type, F".
↑ Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, Dunach M, Neckers LM (Feb 2001). "Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Res. 61 (4): 1671–7. PMID 11245482.
↑ Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (Aug 1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638 . PMID 9245795.
↑ Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi: 10.1073/pnas.92.25.11686 . PMC 40467 . PMID 8524829.
↑ Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Jun 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401 . PMID 7796809.
↑ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi: 10.1074/jbc.273.25.15611 . PMID 9624153.

Chernoff J (1999). "Protein tyrosine phosphatases as negative regulators of mitogenic signaling". J. Cell. Physiol. 180 (2): 173–81. doi:10.1002/(SICI)1097-4652(199908)180:2<173::AID-JCP5>3.0.CO;2-Y. PMID 10395287. S2CID 24952421.
Hashimoto N, Feener EP, Zhang WR, Goldstein BJ (1992). "Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain". J. Biol. Chem. 267 (20): 13811–4. doi: 10.1016/S0021-9258(19)49639-7 . PMID 1321126.
Jirik FR, Harder KW, Melhado IG, Anderson LL, Duncan AM (1993). "The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin". Cytogenet. Cell Genet. 61 (4): 266–8. doi:10.1159/000133418. PMID 1486801.
Streuli M, Krueger NX, Thai T, Tang M, Saito H (1990). "Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR". EMBO J. 9 (8): 2399–407. doi:10.1002/j.1460-2075.1990.tb07415.x. PMC 552264 . PMID 1695146.
Streuli M, Krueger NX, Tsai AY, Saito H (1989). "A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8698–702. Bibcode:1989PNAS...86.8698S. doi: 10.1073/pnas.86.22.8698 . PMC 298355 . PMID 2554325.
Streuli M, Krueger NX, Hall LR, Schlossman SF, Saito H (1988). "A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen". J. Exp. Med. 168 (5): 1523–30. doi:10.1084/jem.168.5.1523. PMC 2189122 . PMID 2972792.
Schaapveld RQ, van den Maagdenberg AM, Schepens JT, Weghuis DO, Geurts van Kessel A, Wieringa B, Hendriks WJ (1995). "The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization". Genomics. 27 (1): 124–30. doi:10.1006/geno.1995.1014. hdl: 2066/21329 . PMID 7665159.
Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401 . PMID 7796809.
O'Grady P, Krueger NX, Streuli M, Saito H (1994). "Genomic organization of the human LAR protein tyrosine phosphatase gene and alternative splicing in the extracellular fibronectin type-III domains". J. Biol. Chem. 269 (40): 25193–9. doi: 10.1016/S0021-9258(17)31516-8 . PMID 7929208.
Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi: 10.1073/pnas.92.25.11686 . PMC 40467 . PMID 8524829.
Liu X, Vega QC, Decker RA, Pandey A, Worby CA, Dixon JE (1996). "Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities". J. Biol. Chem. 271 (10): 5309–12. doi: 10.1074/jbc.271.10.5309 . PMID 8621380.
Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5466–71. Bibcode:1996PNAS...93.5466D. doi: 10.1073/pnas.93.11.5466 . PMC 39269 . PMID 8643598.
Zhang WR, Li PM, Oswald MA, Goldstein BJ (1996). "Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR". Mol. Endocrinol. 10 (5): 575–84. doi: 10.1210/mend.10.5.8732688 . PMID 8732688. S2CID 42128485.
Tabiti K, Cui L, Chhatwal VJ, Moochhala S, Ngoi SS, Pallen CJ (1996). "Novel alternative splicing predicts a secreted extracellular isoform of the human receptor-like protein tyrosine phosphatase LAR". Gene. 175 (1–2): 7–13. doi:10.1016/0378-1119(96)00113-8. PMID 8917069.
Ahmad F, Goldstein BJ (1997). "Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells". J. Biol. Chem. 272 (1): 448–57. doi: 10.1074/jbc.272.1.448 . PMID 8995282.
Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638 . PMID 9245795.
Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi: 10.1074/jbc.273.25.15611 . PMID 9624153.
O'Grady P, Thai TC, Saito H (1998). "The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR". J. Cell Biol. 141 (7): 1675–84. doi:10.1083/jcb.141.7.1675. PMC 2133008 . PMID 9647658.
Chiplunkar S, Chamblis K, Chwa M, Rosenberg S, Kenney MC, Brown DJ (1999). "Enhanced expression of a transmembrane phosphotyrosine phosphatase (LAR) in keratoconus cultures and corneas". Exp. Eye Res. 68 (3): 283–93. doi:10.1006/exer.1998.0604. PMID 10079136.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142949 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033295 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7558042-5] Harder KW, Saw J, Miki N, Jirik F (Nov 1995). "Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line". Genomics. 27 (3): 552–3. doi:10.1006/geno.1995.1092. PMID 7558042.

[entrez-6] 1 2 "Entrez Gene: PTPRF protein tyrosine phosphatase, receptor type, F".

[pmid11245482-7] Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, Dunach M, Neckers LM (Feb 2001). "Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Res. 61 (4): 1671–7. PMID 11245482.

[pmid9245795-8] Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (Aug 1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638 . PMID 9245795.

[pmid8524829-9] Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi: 10.1073/pnas.92.25.11686 . PMC 40467 . PMID 8524829.

[pmid7796809-10] Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Jun 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401 . PMID 7796809.

[pmid9624153-11] Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi: 10.1074/jbc.273.25.15611 . PMID 9624153.

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PTPRF

Contents

Interactions

Related Research Articles

References

Further reading