MTMR6

MTMR6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YF0
Identifiers
Aliases	MTMR6 , myotubularin related protein 6
External IDs	OMIM: 603561; MGI: 2145637; HomoloGene: 55842; GeneCards: MTMR6; OMA:MTMR6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q12.13 Start 25,246,201 bp [1] End 25,288,009 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D1 Start 60,265,228 bp [2] End 60,302,370 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus visceral pleura palpebral conjunctiva frontal pole glomerulus metanephric glomerulus parietal pleura sperm Top expressed in spermatocyte spermatid substantia nigra sciatic nerve facial motor nucleus barrel cortex trigeminal ganglion superior cervical ganglion aortic valve iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity hydrolase activity protein serine/threonine phosphatase activity phosphatidylinositol phosphate phosphatase activity calcium-activated potassium channel activity protein binding phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity phosphatidylinositol-3-phosphatase activity phosphatidylinositol-3,5-bisphosphate phosphatase activity Cellular component cytosol nucleus cytoplasm nuclear envelope endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment plasma membrane membrane ruffle membrane cell projection perinuclear region of cytoplasm Biological process phosphatidylinositol biosynthetic process protein dephosphorylation dephosphorylation potassium ion transmembrane transport peptidyl-tyrosine dephosphorylation phosphatidylinositol dephosphorylation lipid metabolism endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9107 219135 Ensembl ENSG00000139505 ENSMUSG00000021987 UniProt Q9Y217 Q8VE11 RefSeq (mRNA) NM_004685 NM_144843 RefSeq (protein) NP_004676 NP_659092 NP_001388127 NP_001388129 NP_001388128 Location (UCSC) Chr 13: 25.25 – 25.29 Mb Chr 14: 60.27 – 60.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene. ^{[5] [6]}

Interactions

MTMR6 has been shown to interact with MTMR9. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000139505 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021987 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (Dec 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi: 10.1093/hmg/7.11.1703 . PMID   9736772.
6. "Entrez Gene: MTMR6 myotubularin related protein 6".
7. Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. Bibcode:2003PNAS..100.9768M. doi: 10.1073/pnas.1333958100 . PMC   187840 . PMID   12890864.

Further reading

• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Schaletzky J, Dove SK, Short B, Lorenzo O, Clague MJ, Barr FA (2003). "Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases". Curr. Biol. 13 (6): 504–9. Bibcode:2003CBio...13..504S. doi: 10.1016/S0960-9822(03)00132-5 . PMID   12646134.
• Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA (2003). "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8660–5. Bibcode:2003PNAS..100.8660N. doi: 10.1073/pnas.1033097100 . PMC   166368 . PMID   12847286.
• Mochizuki Y, Majerus PW (2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. Bibcode:2003PNAS..100.9768M. doi: 10.1073/pnas.1333958100 . PMC   187840 . PMID   12890864.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY (2006). "Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells". Mol. Cell. Biol. 26 (15): 5595–602. doi:10.1128/MCB.00352-06. PMC   1592754 . PMID   16847315.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Myotubularin-related protein 6 (MTMR6)