RNGTT

RNGTT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C46, 3S24
Identifiers
Aliases	RNGTT , CAP1A, HCE, HCE1, hCAP, RNA guanylyltransferase and 5'-phosphatase
External IDs	OMIM: 603512 MGI: 1329041 HomoloGene: 37851 GeneCards: RNGTT
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q15 Start 88,609,897 bp [1] End 88,963,618 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A5 Start 33,310,311 bp [2] End 33,502,614 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardia nipple pylorus superior surface of tongue ventral tegmental area subthalamic nucleus inferior ganglion of vagus nerve renal medulla trigeminal ganglion body of tongue Top expressed in extraocular muscle spermatocyte abdominal wall thymus ganglionic eminence maxillary prominence plantaris muscle morula cingulate gyrus spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine/serine/threonine phosphatase activity phosphatase activity protein tyrosine phosphatase activity polynucleotide 5'-phosphatase activity RNA guanylyltransferase activity triphosphatase activity nucleotidyltransferase activity mRNA guanylyltransferase activity catalytic activity hydrolase activity nucleotide binding GTP binding transferase activity protein binding Cellular component nucleus nucleoplasm Biological process mRNA processing RNA processing protein dephosphorylation transcription by RNA polymerase II dephosphorylation 7-methylguanosine mRNA capping metabolism peptidyl-tyrosine dephosphorylation polynucleotide 5' dephosphorylation viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8732 24018 Ensembl ENSG00000111880 ENSMUSG00000028274 UniProt O60942 O55236 RefSeq (mRNA) NM_001286426 NM_001286428 NM_003800 NM_011884 NM_001305273 RefSeq (protein) NP_001273355 NP_001273357 NP_003791 NP_001292202 NP_036014 Location (UCSC) Chr 6: 88.61 – 88.96 Mb Chr 4: 33.31 – 33.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000111880 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028274 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (Jan 1999). "Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively". Genomics. 54 (2): 351–3. doi:10.1006/geno.1998.5604. PMID   9828141.
6. Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H (May 1998). "Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme". Nucleic Acids Res. 26 (7): 1700–6. doi:10.1093/nar/26.7.1700. PMC   147440 . PMID   9512541.
7. "Entrez Gene: RNGTT RNA guanylyltransferase and 5'-phosphatase".

Further reading

• Yue Z, Maldonado E, Pillutla R, Cho H, Reinberg D, Shatkin AJ (1998). "Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12898–903. doi: 10.1073/pnas.94.24.12898 . PMC   24235 . PMID   9371772.
• Tsukamoto T, Shibagaki Y, Murakoshi T, Suzuki M, Nakamura A, Gotoh H, Mizumoto K (1998). "Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme". Biochem. Biophys. Res. Commun. 243 (1): 101–8. doi:10.1006/bbrc.1997.8038. PMID   9473487.
• Pillutla RC, Yue Z, Maldonado E, Shatkin AJ (1998). "Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes". J. Biol. Chem. 273 (34): 21443–6. doi: 10.1074/jbc.273.34.21443 . PMID   9705270.
• Wen Y, Shatkin AJ (1999). "Transcription elongation factor hSPT5 stimulates mRNA capping". Genes Dev. 13 (14): 1774–9. doi:10.1101/gad.13.14.1774. PMC   316881 . PMID   10421630.
• Chiu YL, Coronel E, Ho CK, Shuman S, Rana TM (2001). "HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA". J. Biol. Chem. 276 (16): 12959–66. doi: 10.1074/jbc.M007901200 . PMID   11278368.
• Chiu YL, Ho CK, Saha N, Schwer B, Shuman S, Rana TM (2002). "Tat stimulates cotranscriptional capping of HIV mRNA". Mol. Cell. 10 (3): 585–97. doi: 10.1016/S1097-2765(02)00630-5 . PMID   12408826.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhou M, Deng L, Kashanchi F, Brady JN, Shatkin AJ, Kumar A (2004). "The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12666–71. doi: 10.1073/pnas.1835726100 . PMC   240675 . PMID   14569024.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human mRNA-capping enzyme (RNGTT)