PTPRZ1

PTPRZ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JXF, 3S97, 5AWX
Identifiers
Aliases	PTPRZ1 , HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, protein tyrosine phosphatase, receptor type Z1, protein tyrosine phosphatase receptor type Z1
External IDs	OMIM: 176891 MGI: 97816 HomoloGene: 2136 GeneCards: PTPRZ1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q31.32 Start 121,873,089 bp [1] End 122,062,036 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A3.1 Start 22,875,501 bp [2] End 23,052,915 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence endothelial cell amygdala Region I of hippocampus proper optic nerve caudate nucleus nucleus accumbens corpus callosum external globus pallidus substantia nigra Top expressed in mammillary body median eminence ventromedial nucleus arcuate nucleus cerebellar vermis dorsomedial hypothalamic nucleus substantia nigra lateral hypothalamus suprachiasmatic nucleus olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity hydrolase activity integrin binding Cellular component integral component of membrane membrane integral component of plasma membrane extracellular region perineuronal net intrinsic component of plasma membrane plasma membrane extracellular matrix synapse Biological process axonogenesis protein dephosphorylation oligodendrocyte differentiation regulation of oligodendrocyte progenitor proliferation central nervous system development hematopoietic progenitor cell differentiation learning or memory peptidyl-tyrosine dephosphorylation dephosphorylation cytokine-mediated signaling pathway regulation of myelination negative regulation of neuron apoptotic process positive regulation of oligodendrocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5803 19283 Ensembl ENSG00000106278 ENSMUSG00000068748 UniProt P23471 B9EKR1 RefSeq (mRNA) NM_001206838 NM_001206839 NM_002851 NM_001369395 NM_001369396 NM_001081306 NM_011219 NM_178180 NM_001311064 NM_001361349 RefSeq (protein) NP_001193767 NP_001193768 NP_002842 NP_001074775 NP_001297993 NP_001348278 NP_035349 NP_001389981 NP_001389982 NP_001389983 Location (UCSC) Chr 7: 121.87 – 122.06 Mb Chr 6: 22.88 – 23.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene. ^{[5] [6] [7]}

Function

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined. ^[7]

Clinical significance

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000106278 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068748 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T, Yakura H (Jun 1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenet Cell Genet. 70 (1–2): 52–4. doi:10.1159/000133990. PMID   7736789.
6. Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM, Huang JT, Cannizzaro LA, Park SH, Druck T (Jun 1993). "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". J Biol Chem. 268 (14): 10573–81. doi: 10.1016/S0021-9258(18)82237-2 . PMID   8387522.
7. "Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1".

Further reading

• Krueger NX, Saito H (1992). "A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases". Proc. Natl. Acad. Sci. U.S.A. 89 (16): 7417–21. Bibcode:1992PNAS...89.7417K. doi: 10.1073/pnas.89.16.7417 . PMC   49721 . PMID   1323835.
• Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J (1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7000–4. Bibcode:1990PNAS...87.7000K. doi: 10.1073/pnas.87.18.7000 . PMC   54670 . PMID   2169617.
• Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases". EMBO J. 9 (10): 3241–52. doi:10.1002/j.1460-2075.1990.tb07523.x. PMC   552056 . PMID   2170109.
• Morton SM, Veile RA, Helms C, Lee M, Kuo WL, Gray J, Donis-Keller H (1998). "Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s". Genomics. 46 (3): 491–4. doi:10.1006/geno.1997.5051. PMID   9441757.
• Onyango P, Lubyova B, Gardellin P, Kurzbauer R, Weith A (1998). "Molecular cloning and expression analysis of five novel genes in chromosome 1p36". Genomics. 50 (2): 187–98. doi:10.1006/geno.1997.5186. PMID   9653645.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Maeda N, Ichihara-Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M (1999). "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta". J. Biol. Chem. 274 (18): 12474–9. doi: 10.1074/jbc.274.18.12474 . PMID   10212223.
• Kawachi H, Tamura H, Watakabe I, Shintani T, Maeda N, Noda M (1999). "Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family". Brain Res. Mol. Brain Res. 72 (1): 47–54. doi:10.1016/S0169-328X(99)00204-1. PMID   10521598.
• Meng K, Rodriguez-Peña A, Dimitrov T, Chen W, Yamin M, Noda M, Deuel TF (2000). "Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2603–8. doi: 10.1073/pnas.020487997 . PMC   15975 . PMID   10706604.
• Kawachi H, Fujikawa A, Maeda N, Noda M (2001). "Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system". Proc. Natl. Acad. Sci. U.S.A. 98 (12): 6593–8. Bibcode:2001PNAS...98.6593K. doi: 10.1073/pnas.041608698 . PMC   34398 . PMID   11381105.
• Thomaidou D, Coquillat D, Meintanis S, Noda M, Rougon G, Matsas R (2001). "Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells". J. Neurochem. 78 (4): 767–78. doi: 10.1046/j.1471-4159.2001.00454.x . PMID   11520897. S2CID   24682985.
• Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, Buxbaum JD, Schlessinger J (2002). "A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions". Nat. Genet. 32 (3): 411–4. doi:10.1038/ng1004. PMID   12355066. S2CID   19800079.
• Müller S, Kunkel P, Lamszus K, Ulbricht U, Lorente GA, Nelson AM, von Schack D, Chin DJ, Lohr SC, Westphal M, Melcher T (2003). "A role for receptor tyrosine phosphatase zeta in glioma cell migration". Oncogene. 22 (43): 6661–8. doi: 10.1038/sj.onc.1206763 . PMID   14555979.
• Bonora E, Lamb JA, Barnby G, Sykes N, Moberly T, Beyer KS, Klauck SM, Poustka F, Bacchelli E, Blasi F, Maestrini E, Battaglia A, Haracopos D, Pedersen L, Isager T, Eriksen G, Viskum B, Sorensen EU, Brondum-Nielsen K, Cotterill R, van Engeland H, de Jonge M, Kemner C, Steggehuis K, Scherpenisse M, Rutter M, Bolton PF, Parr JR, Poustka A, Bailey AJ, Monaco AP (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. 13 (2): 198–207. doi: 10.1038/sj.ejhg.5201315 . PMID   15523497.
• Polykratis A, Katsoris P, Courty J, Papadimitriou E (2005). "Characterization of heparin affin regulatory peptide signaling in human endothelial cells". J. Biol. Chem. 280 (23): 22454–61. doi: 10.1074/jbc.M414407200 . PMID   15797857.
• Wang V, Davis DA, Haque M, Huang LE, Yarchoan R (2005). "Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells". Cancer Res. 65 (8): 3299–306. doi: 10.1158/0008-5472.CAN-04-4130 . PMID   15833863.
• Lu KV, Jong KA, Kim GY, Singh J, Dia EQ, Yoshimoto K, Wang MY, Cloughesy TF, Nelson SF, Mischel PS (2005). "Differential induction of glioblastoma migration and growth by two forms of pleiotrophin". J. Biol. Chem. 280 (29): 26953–64. doi: 10.1074/jbc.M502614200 . PMID   15908427.