ACP1

ACP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XWW, 3N8I, 4Z99, 4Z9A, 4Z9B, 5PNT
Identifiers
Aliases	ACP1 , HAAP, LMW-PTP, acid phosphatase 1, soluble, LMWPTP, acid phosphatase 1
External IDs	OMIM: 171500; MGI: 87881; HomoloGene: 38274; GeneCards: ACP1; OMA:ACP1 - orthologs
EC number	3.1.3.2
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p25.3 Start 264,140 bp [1] End 278,283 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A2 Start 30,943,325 bp [2] End 30,961,588 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Achilles tendon left adrenal gland right adrenal cortex left adrenal cortex ventricular zone islet of Langerhans body of pancreas right testis embryo Top expressed in embryo embryo genital tubercle right kidney tail of embryo blastocyst ventricular zone yolk sac spermatid muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein binding non-membrane spanning protein tyrosine phosphatase activity acid phosphatase activity Cellular component cytoplasm cytoplasmic side of plasma membrane extracellular exosome cytosol sarcolemma Biological process protein dephosphorylation peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 52 11431 Ensembl ENSG00000143727 ENSMUSG00000044573 UniProt P24666 Q9D358 RefSeq (mRNA) NM_001040649 NM_004300 NM_007099 NM_177554 NM_001110239 NM_021330 RefSeq (protein) NP_001035739 NP_004291 NP_009030 NP_001103709 NP_067305 Location (UCSC) Chr 2: 0.26 – 0.28 Mb Chr 12: 30.94 – 30.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene. ^[5]

Clinical significance

Clinically, increased expression of ACP1 is a biomarker for poor prognosis in prostate cancer has been linked to worse clinical behaviour of prostate cancer, possibly outperforming the widely used Gleason grading system with respect to this important parameter. ^[6] Also in other cancers, e.g. colon cancer, high ACP1 protein levels are linked to aggressive disease. ^[7] It has been suggested that ACP1 acts as a bona fide oncogene, but for now this notion remains unproven even if ACP1 overexpression drives cells towards a Warburg effect-like glycolytic phenotype. ^[8] Apart from cancer, ACP1 has also been linked to osteoporosis as the enzyme plays an important role in the interaction of the osteocyte with the bone environment, ^[9] while its inhibition appears useful for counteracting experimental [venous thromboembolism]. ^[10] Currently, there are no clinically approved inhibitors that allow targeting ACP1 in patients.

Interactions

ACP1 has been shown to interact with EPH receptor A2 ^[11] and EPH receptor B1. ^[12] The proto-oncogene Src has been suggested to be a direct target for ACP1 tyrosine phosphatase activity, but this has not been formally proven. ^[13]

References

1. GRCh38: Ensembl release 89: ENSG00000143727 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044573 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ACP1 acid phosphatase 1, soluble".
6. Ruela-de-Sousa RR, Hoekstra E, Hoogland AM, Souza Queiroz KC, Peppelenbosch MP, Stubbs AP, et al. (April 2016). "Low-Molecular-Weight Protein Tyrosine Phosphatase Predicts Prostate Cancer Outcome by Increasing the Metastatic Potential". European Urology. 69 (4): 710–719. doi:10.1016/j.eururo.2015.06.040. hdl: 1765/79946 . PMID   26159288.
7. Faria AV, Yu B, Mommersteeg M, de Souza-Oliveira PF, Andrade SS, Spaander MC, et al. (January 2022). "Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1868 (1): 166280. doi: 10.1016/j.bbadis.2021.166280 . PMID   34610471.
8. Faria AV, Tornatore TF, Milani R, Queiroz KC, Sampaio IH, Fonseca EM, et al. (November 2017). "Oncophosphosignaling Favors a Glycolytic Phenotype in Human Drug Resistant Leukemia". Journal of Cellular Biochemistry. 118 (11): 3846–3854. doi:10.1002/jcb.26034. PMID   28387439. S2CID   3915599.
9. Fernandes GV, Cavagis AD, Ferreira CV, Olej B, Leão M, Yano CL, et al. (June 2014). "Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP". Journal of Cellular Biochemistry. 115 (6): 1063–1069. doi:10.1002/jcb.24691. PMID   24123071. S2CID   7383008.
10. Faria AV, Andrade SS, Reijm AN, Spaander MC, de Maat MP, Peppelenbosch MP, et al. (June 2019). "Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients". Journal of Clinical Medicine. 8 (7): 936. doi: 10.3390/jcm8070936 . PMC   6678874 . PMID   31261776.
11. Kikawa KD, Vidale DR, Van Etten RL, Kinch MS (October 2002). "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". The Journal of Biological Chemistry. 277 (42): 39274–39279. doi: 10.1074/jbc.M207127200 . PMID   12167657.
12. Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO (March 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes & Development. 12 (5): 667–678. doi:10.1101/gad.12.5.667. PMC   316584 . PMID   9499402.
13. Zambuzzi WF, Granjeiro JM, Parikh K, Yuvaraj S, Peppelenbosch MP, Ferreira CV (2008). "Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation". Cellular Physiology and Biochemistry. 22 (5–6): 497–506. doi: 10.1159/000185506 . PMID   19088431.

External links

• Human ACP1 genome location and ACP1 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : P24666 (Human Low molecular weight phosphotyrosine protein phosphatase) at the PDBe-KB .
• Overview of all the structural information available in the PDB for UniProt : Q9D358 (Mouse Low molecular weight phosphotyrosine protein phosphatase) at the PDBe-KB .

Further reading

• Junien C, Kaplan JC, Bernheim A, Berger R (April 1979). "Regional assignment of red cell acid phosphatase locus to band 2p25". Human Genetics. 48 (1): 17–21. doi:10.1007/BF00273269. PMID   457131. S2CID   422040.
• Sensabaugh GF, Golden VL (September 1978). "Phenotype dependence in the inhibition of red cell acid phosphatase (ACP) by folates". American Journal of Human Genetics. 30 (5): 553–560. PMC   1685602 . PMID   736044.
• Shekels LL, Smith AJ, Van Etten RL, Bernlohr DA (June 1992). "Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase". Protein Science. 1 (6): 710–721. doi:10.1002/pro.5560010603. PMC   2142247 . PMID   1304913.
• Wo YY, McCormack AL, Shabanowitz J, Hunt DF, Davis JP, Mitchell GL, Van Etten RL (May 1992). "Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase". The Journal of Biological Chemistry. 267 (15): 10856–10865. doi: 10.1016/S0021-9258(19)50097-7 . PMID   1587862.
• Dissing J, Johnsen AH (June 1992). "Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1121 (3): 261–268. doi:10.1016/0167-4838(92)90155-7. PMID   1627603.
• Dissing J, Johnsen AH, Sensabaugh GF (November 1991). "Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele". The Journal of Biological Chemistry. 266 (31): 20619–20625. doi: 10.1016/S0021-9258(18)54754-2 . PMID   1939112.
• Wakita Y, Narahara K, Takahashi Y, Kikkawa K, Kimura S, Oda M, Kimoto H (1986). "Duplication of 2p25: confirmation of the assignment of soluble acid phosphatase (ACP1) locus to 2p25". Human Genetics. 71 (3): 259–260. doi:10.1007/BF00284586. PMID   4065897. S2CID   10610694.
• Blake NM, Kirk RL, Barnes KR, Thompson JM (June 1973). "Expression of human red cell acid phosphatase activity in placenta and other tissues". Jinrui Idengaku Zasshi. The Japanese Journal of Human Genetics. 18 (1): 10–23. PMID   4356849.
• Sensabaugh GF, Lazaruk KA (July 1993). "A TaqI site identifies the *A allele at the ACP1 locus". Human Molecular Genetics. 2 (7): 1079. doi:10.1093/hmg/2.7.1079-a. PMID   8364553.
• Bryson GL, Massa H, Trask BJ, Van Etten RL (November 1995). "Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1". Genomics. 30 (2): 133–140. doi:10.1006/geno.1995.9893. PMID   8586411.
• Tailor P, Gilman J, Williams S, Couture C, Mustelin T (February 1997). "Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132". The Journal of Biological Chemistry. 272 (9): 5371–5374. doi: 10.1074/jbc.272.9.5371 . PMID   9038134.
• Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO (March 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes & Development. 12 (5): 667–678. doi:10.1101/gad.12.5.667. PMC   316584 . PMID   9499402.
• Modesti A, Marzocchini R, Raugei G, Chiti F, Sereni A, Magherini F, Ramponi G (July 1998). "Cloning, expression and characterisation of a new human low Mr phosphotyrosine protein phosphatase originating by alternative splicing". FEBS Letters. 431 (1): 111–115. doi: 10.1016/S0014-5793(98)00732-7 . PMID   9684876. S2CID   38383291.
• Zhang M, Stauffacher CV, Lin D, Van Etten RL (August 1998). "Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity". The Journal of Biological Chemistry. 273 (34): 21714–21720. doi: 10.1074/jbc.273.34.21714 . PMID   9705307.
• Tailor P, Gilman J, Williams S, Mustelin T (June 1999). "A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing". European Journal of Biochemistry. 262 (2): 277–282. doi: 10.1046/j.1432-1327.1999.00353.x . PMID   10336608.
• Huang L, Sankar S, Lin C, Kontos CD, Schroff AD, Cha EH, et al. (December 1999). "HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity". The Journal of Biological Chemistry. 274 (53): 38183–38188. doi: 10.1074/jbc.274.53.38183 . PMID   10608891.
• Nicolas G, Fournier CM, Galand C, Malbert-Colas L, Bournier O, Kroviarski Y, et al. (May 2002). "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain". Molecular and Cellular Biology. 22 (10): 3527–3536. doi:10.1128/MCB.22.10.3527-3536.2002. PMC   133798 . PMID   11971983.
• Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, et al. (July 2002). "Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP)". The Journal of Biological Chemistry. 277 (27): 24220–24224. doi: 10.1074/jbc.M202885200 . PMID   11976341.
• Bottini N, Ammendola M, Gloria-Bottini F (July 2002). "ACP1 is associated with allergy". Allergy. 57 (7): 651–652. doi:10.1034/j.1398-9995.2002.23722.x. PMID   12100313. S2CID   42578825.
• Kikawa KD, Vidale DR, Van Etten RL, Kinch MS (October 2002). "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". The Journal of Biological Chemistry. 277 (42): 39274–39279. doi: 10.1074/jbc.M207127200 . PMID   12167657.