PTPN13

PTPN13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D5G, 1Q7X, 1WCH, 2M0Z, 2M10, 3LNX, 3LNY, 3PDZ
Identifiers
Aliases	PTPN13 , FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, protein tyrosine phosphatase, non-receptor type 13, protein tyrosine phosphatase non-receptor type 13
External IDs	OMIM: 600267 MGI: 103293 HomoloGene: 7909 GeneCards: PTPN13
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q21.3 Start 86,594,315 bp [1] End 86,815,171 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 E5|5 50.43 cM Start 103,573,058 bp [2] End 103,746,169 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urethra human penis palpebral conjunctiva retinal pigment epithelium renal medulla trigeminal ganglion Achilles tendon spinal ganglia corpus callosum skin of abdomen Top expressed in corneal stroma hair follicle mucosa of urinary bladder retinal pigment epithelium medullary collecting duct conjunctival fornix skin of back sciatic nerve skin of abdomen seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity phosphatidylinositol 3-kinase regulatory subunit binding protein binding phosphoprotein phosphatase activity hydrolase activity Cellular component cytoplasm cell body neuron projection cell projection extracellular exosome cytoskeleton nucleus lamellipodium plasma membrane nucleoplasm Biological process protein dephosphorylation peptidyl-tyrosine dephosphorylation regulation of phosphatidylinositol 3-kinase signaling dephosphorylation phosphatidylinositol biosynthetic process negative regulation of protein phosphorylation cellular response to cytokine stimulus bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5783 19249 Ensembl ENSG00000163629 ENSMUSG00000034573 UniProt Q12923 Q64512 RefSeq (mRNA) NM_006264 NM_080683 NM_080684 NM_080685 NM_011204 RefSeq (protein) NP_006255 NP_542414 NP_542415 NP_542416 NP_035334 Location (UCSC) Chr 4: 86.59 – 86.82 Mb Chr 5: 103.57 – 103.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. ^[6]

Interactions

PTPN13 has been shown to interact with PKN2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163629 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034573 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maekawa K, Imagawa N, Nagamatsu M, Harada S (Feb 1994). "Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats". FEBS Lett. 337 (2): 200–206. doi:10.1016/0014-5793(94)80273-4. PMID   8287977. S2CID   46269697.
6. "Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)".
7. Gross C, Heumann R, Erdmann K S (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3): 101–104. doi:10.1016/S0014-5793(01)02401-2. ISSN   0014-5793. PMID   11356191. S2CID   205880882.

Further reading

• Sato T, Irie S, Kitada S, Reed JC (1995). "FAP-1: a protein tyrosine phosphatase that associates with Fas". Science. 268 (5209): 411–415. Bibcode:1995Sci...268..411S. doi:10.1126/science.7536343. PMID   7536343.
• Saras J, Claesson-Welsh L, Heldin CH, Gonez LJ (1994). "Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins". J. Biol. Chem. 269 (39): 24082–9. doi: 10.1016/S0021-9258(19)51050-X . PMID   7929060.
• Banville D, Ahmad S, Stocco R, Shen SH (1994). "A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases". J. Biol. Chem. 269 (35): 22320–7. doi: 10.1016/S0021-9258(17)31792-1 . PMID   8071359.
• Inazawa J, Ariyama T, Abe T, Druck T, Ohta M, Huebner K, Yanagisawa J, Reed JC, Sato T (1997). "PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3". Genomics. 31 (2): 240–242. doi: 10.1006/geno.1996.0039 . PMID   8824809.
• Yanagisawa J, Takahashi M, Kanki H, Yano-Yanagisawa H, Tazunoki T, Sawa E, Nishitoba T, Kamishohara M, Kobayashi E (1997). "The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis". J. Biol. Chem. 272 (13): 8539–8545. doi: 10.1074/jbc.272.13.8539 . PMID   9079683.
• Saras J, Engström U, Góñez LJ, Heldin CH (1997). "Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas". J. Biol. Chem. 272 (34): 20979–20981. doi: 10.1074/jbc.272.34.20979 . PMID   9261095.
• Saras J, Franzén P, Aspenström P, Hellman U, Gonez LJ, Heldin CH (1997). "A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1". J. Biol. Chem. 272 (39): 24333–24338. doi: 10.1074/jbc.272.39.24333 . PMID   9305890.
• Ekiel I, Banville D, Shen SH, Slon-Usakiewicz JJ, Koshy A, Gehring K (1999). "Main-chain signal assignment for the PDZ2 domain from human protein tyrosine phosphatase hPTP1E and its complex with a C-terminal peptide from the Fas receptor". J. Biomol. NMR. 12 (3): 455–456. doi:10.1023/A:1008267807859. PMID   9835052. S2CID   19976473.
• Maekawa K, Imagawa N, Naito A, Harada S, Yoshie O, Takagi S (1999). "Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IkappaBalpha through interaction between the PDZ1 domain and ankyrin repeats". Biochem. J. 337 (2): 179–84. doi:10.1042/0264-6021:3370179. PMC   1219950 . PMID   9882613.
• Lin D, Gish GD, Songyang Z, Pawson T (1999). "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif". J. Biol. Chem. 274 (6): 3726–3733. doi: 10.1074/jbc.274.6.3726 . PMID   9920925.
• Murthy KK, Clark K, Fortin Y, Shen SH, Banville D (1999). "ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E". J. Biol. Chem. 274 (29): 20679–20687. doi: 10.1074/jbc.274.29.20679 . PMID   10400701.
• Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W (1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett. 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6. PMID   10526152. S2CID   41216030.
• Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–198. doi:10.1016/S0014-5793(99)01324-1. PMID   10544233. S2CID   25143664.
• Lee SH, Shin MS, Park WS, Kim SY, Kim HS, Lee JH, Han SY, Lee HK, Park JY (2000). "Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues". APMIS. 107 (12): 1101–1108. doi:10.1111/j.1699-0463.1999.tb01515.x. PMID   10660140. S2CID   24672576.
• Kozlov G, Gehring K, Ekiel I (2000). "Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor". Biochemistry. 39 (10): 2572–2580. doi:10.1021/bi991913c. PMID   10704206.
• Cuppen E, van Ham M, Wansink DG, De Leeuw A, Wieringa B, Hendriks W (2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". Eur. J. Cell Biol. 79 (4): 283–293. doi:10.1078/S0171-9335(04)70031-X. PMID   10826496.
• Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Müller O, Heumann R (2000). "The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain". Oncogene. 19 (34): 3894–3901. doi: 10.1038/sj.onc.1203725 . PMID   10951583.
• Nakai Y, Irie S, Sato TA (2001). "Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1". Eur. J. Biochem. 267 (24): 7170–7175. doi: 10.1046/j.1432-1327.2000.01818.x . PMID   11106428.
• Gross C, Heumann R, Erdmann KS (2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3): 101–104. doi:10.1016/S0014-5793(01)02401-2. PMID   11356191. S2CID   205880882.