PTPN4

PTPN4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CS5, 2VPH, 3NFK, 3NFL, 2I75, 5EZ0, 5EYZ
Identifiers
Aliases	PTPN4 , MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4, protein tyrosine phosphatase non-receptor type 4
External IDs	OMIM: 176878; MGI: 1099792; HomoloGene: 2120; GeneCards: PTPN4; OMA:PTPN4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q14.2 Start 119,759,922 bp [1] End 119,984,899 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 E2.3|1 52.39 cM Start 119,652,467 bp [2] End 119,837,613 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus granulocyte cerebellar vermis Achilles tendon renal medulla paraflocculus of cerebellum Skeletal muscle tissue of rectus abdominis corpus callosum parietal lobe pons Top expressed in lateral geniculate nucleus medial geniculate nucleus medial dorsal nucleus cerebellar vermis lobe of cerebellum Region I of hippocampus proper triceps brachii muscle spermatid superior colliculus temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity cytoskeletal protein binding protein binding phosphoprotein phosphatase activity hydrolase activity non-membrane spanning protein tyrosine phosphatase activity Cellular component cytoplasm cytoplasmic side of plasma membrane plasma membrane cytoskeleton membrane nucleoplasm cytosol Biological process protein dephosphorylation peptidyl-tyrosine dephosphorylation dephosphorylation cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5775 19258 Ensembl ENSG00000088179 ENSMUSG00000026384 UniProt P29074 Q9WU22 RefSeq (mRNA) NM_002830 NM_019933 RefSeq (protein) NP_002821 NP_064317 Location (UCSC) Chr 2: 119.76 – 119.98 Mb Chr 1: 119.65 – 119.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene. ^{[5] [6]}

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. ^[6]

Interactions

PTPN4 has been shown to interact with GRID2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000088179 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026384 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. Bibcode:1991PNAS...88.5867G. doi: 10.1073/pnas.88.13.5867 . PMC   51979 . PMID   1648233.
6. "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)".
7. Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi: 10.1074/jbc.M909302199 . PMID   10748123.

Further reading

• Gu M, Majerus PW (1996). "The properties of the protein tyrosine phosphatase PTPMEG". J. Biol. Chem. 271 (44): 27751–9. doi: 10.1074/jbc.271.44.27751 . PMID   8910369.
• Gu M, Meng K, Majerus PW (1996). "The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12980–5. Bibcode:1996PNAS...9312980G. doi: 10.1073/pnas.93.23.12980 . PMC   24032 . PMID   8917530.
• Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi: 10.1074/jbc.M909302199 . PMID   10748123.
• Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID   10940933. S2CID   8132613.
• Park KW, Lee EJ, Lee S, Lee JE, Choi E, Kim BJ, Hwang R, Park KA, Baik J (2001). "Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG". Gene. 257 (1): 45–55. doi:10.1016/S0378-1119(00)00351-6. PMID   11054567.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.

External links

• Overview of all the structural information available in the PDB for UniProt : P29074 (Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)) at the PDBe-KB .