PTPN4

PTPN4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CS5, 2VPH, 3NFK, 3NFL, 2I75, 5EZ0, 5EYZ
Identifiers
Aliases	PTPN4 , MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4, protein tyrosine phosphatase non-receptor type 4
External IDs	OMIM: 176878 MGI: 1099792 HomoloGene: 2120 GeneCards: PTPN4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	119,984,899 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	119,837,613 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; Achilles tendon; ; renal medulla; ; corpus callosum; ; parietal lobe; ; pons; ; postcentral gyrus; ; blood; ; frontal pole; ; ganglionic eminence;
	Top expressed in
	lateral geniculate nucleus; ; medial geniculate nucleus; ; medial dorsal nucleus; ; cerebellar vermis; ; Region I of hippocampus proper; ; triceps brachii muscle; ; spermatid; ; superior colliculus; ; temporal muscle; ; intercostal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity ; phosphatase activity ; cytoskeletal protein binding ; protein binding ; phosphoprotein phosphatase activity ; hydrolase activity ; non-membrane spanning protein tyrosine phosphatase activity ;
Cellular component	cytoplasm ; cytoplasmic side of plasma membrane ; plasma membrane ; cytoskeleton ; membrane ; nucleoplasm ; cytosol ;
Biological process	protein dephosphorylation ; peptidyl-tyrosine dephosphorylation ; dephosphorylation ; cellular response to cytokine stimulus ;
	Sources:Amigo / QuickGO
Orthologs
	5775
	19258
	ENSG00000088179
	ENSMUSG00000026384
	P29074
	Q9WU22
	NM_002830
	NM_019933
	NP_002821
	NP_064317
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.^[6]

Interactions

PTPN4 has been shown to interact with GRID2.^[7]

Related Research Articles

<span class="mw-page-title-main">Protein tyrosine phosphatase</span> Class of enzymes

Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins:

<span class="mw-page-title-main">PTPN11</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene. PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the PTPRF gene.

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.

Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene.

Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.

Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ₂, is a protein that in humans is encoded by the GRID2 gene. This protein together with GluD1 belongs to the delta receptor subtype of ionotropic glutamate receptors. They possess 14–24% sequence homology with AMPA, kainate, and NMDA subunits, but, despite their name, do not actually bind glutamate or various other glutamate agonists.

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.

Protein tyrosine phosphatase non-receptor type 5 is an enzyme that in humans is encoded by the PTPN5 gene.

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000088179 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026384 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. Bibcode:1991PNAS...88.5867G. doi: 10.1073/pnas.88.13.5867 . PMC 51979 . PMID 1648233.
1 2 "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)".
↑ Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi: 10.1074/jbc.M909302199 . PMID 10748123.

External links

Overview of all the structural information available in the PDB for UniProt : P29074 (Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)) at the PDBe-KB .

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000088179 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026384 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1648233-5] Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. Bibcode:1991PNAS...88.5867G. doi: 10.1073/pnas.88.13.5867 . PMC 51979 . PMID 1648233.

[entrez-6] 1 2 "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)".

[pmid10748123-7] Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi: 10.1074/jbc.M909302199 . PMID 10748123.

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