CDC14A

CDC14A
Identifiers
Aliases	CDC14A , cdc14, hCDC14, cell division cycle 14A, DFNB105, DFNB35, DFNB32
External IDs	OMIM: 603504; MGI: 2442676; HomoloGene: 75343; GeneCards: CDC14A; OMA:CDC14A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p21.2 Start 100,345,001 bp [1] End 100,520,277 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G1 Start 116,272,553 bp [2] End 116,428,745 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm buccal mucosa cell mucosa of paranasal sinus right uterine tube right testis left testis glomerulus metanephric glomerulus olfactory zone of nasal mucosa Achilles tendon Top expressed in ciliary body iris retinal pigment epithelium otolith organ utricle spermatid vestibular sensory epithelium olfactory epithelium intercostal muscle cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein serine/threonine phosphatase activity protein binding protein tyrosine phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component centrosome spindle nucleoplasm microtubule organizing center mitotic spindle cytoskeleton nucleus spindle pole cytoplasm cytosol nuclear body cell projection kinocilium stereocilium tip kinociliary basal body nucleolus stereocilium Biological process mitotic spindle midzone assembly protein dephosphorylation cell division cell cycle cell population proliferation dephosphorylation peptidyl-tyrosine dephosphorylation regulation of exit from mitosis cilium assembly hearing microtubule cytoskeleton organization mitotic cell cycle positive regulation of cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8556 229776 Ensembl ENSG00000079335 ENSMUSG00000033502 UniProt Q9UNH5 Q6GQT0 RefSeq (mRNA) NM_003672 NM_033312 NM_033313 NM_001319210 NM_001319211 NM_001319212 NM_001080818 NM_001173553 NM_001355646 NM_001378993 NM_001378994 RefSeq (protein) NP_001306139 NP_001306140 NP_001306141 NP_003663 NP_201569 NP_201570 NP_001074287 NP_001167024 NP_001342575 NP_001365922 NP_001365923 Location (UCSC) Chr 1: 100.35 – 100.52 Mb Chr 3: 116.27 – 116.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene. ^{[5] [6] [7]}

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. ^[7]

Interactions

CDC14A has been shown to interact with P53, de-phosphorylate p53 at Serine 315 and thereby stabilize p53. ^[8] S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000079335 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033502 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem. 272 (47): 29403–6. doi: 10.1074/jbc.272.47.29403 . PMID   9367992.
6. Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (September 1999). "Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene". Genomics. 59 (2): 248–51. doi:10.1006/geno.1999.5863. PMID   10409437.
7. "Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)".
8. Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 at Serine 315". J. Biol. Chem. 275 (4): 2410–4. doi: 10.1074/jbc.275.4.2410 . ISSN   0021-9258. PMID   10644693.
9. Li, Y; Cui K; Zhang Q; Li X; Lin X; Tang Y; Prochownik E; Li Y (July 2021). "FBXL6 degrades phosphorylated p53 to promote tumor growth". Cell Death Differ. 28 (7): 2112–2125. doi: 10.1038/s41418-021-00739-6 . ISSN   1350-9047. PMC   8257708 . PMID   33568778.

External links

• Human CDC14A genome location and CDC14A gene details page in the UCSC Genome Browser .

Further reading

• Li L, Ljungman M, Dixon JE (2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. 275 (4): 2410–4. doi: 10.1074/jbc.275.4.2410 . PMID   10644693.
• Bembenek J, Yu H (2002). "Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a". J. Biol. Chem. 276 (51): 48237–42. doi: 10.1074/jbc.M108126200 . PMID   11598127.
• Mailand N, Lukas C, Kaiser BK, et al. (2002). "Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation". Nat. Cell Biol. 4 (4): 317–22. doi:10.1038/ncb777. PMID   11901424. S2CID   28955777.
• Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK (2003). "Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase". Mol. Biol. Cell. 13 (7): 2289–300. doi:10.1091/mbc.01-11-0535. PMC   117313 . PMID   12134069.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gruneberg U, Neef R, Honda R, et al. (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMC   2172317 . PMID   15263015.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP (2005). "Functional homology among human and fission yeast Cdc14 phosphatases". J. Biol. Chem. 280 (32): 29144–50. doi: 10.1074/jbc.M413328200 . hdl: 10366/157107 . PMID   15911625.
• Zhao H, Wang Q, Zhang H, et al. (2006). "UXT is a novel centrosomal protein essential for cell viability". Mol. Biol. Cell. 16 (12): 5857–65. doi:10.1091/mbc.E05-08-0705. PMC   1289427 . PMID   16221885.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Sanchez M, Galy B, Dandekar T, et al. (2006). "Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy". J. Biol. Chem. 281 (32): 22865–74. doi: 10.1074/jbc.M603876200 . PMID   16760464.
• Paulsen MT, Starks AM, Derheimer FA, et al. (2006). "The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers". Mol. Cancer. 5: 25. doi: 10.1186/1476-4598-5-25 . PMC   1524803 . PMID   16784539.
• Esteban V, Vázquez-Novelle MD, Calvo E, et al. (2007). "Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320". Cell Cycle. 5 (24): 2894–8. doi: 10.4161/cc.5.24.3566 . hdl: 10261/60508 . PMID   17172867.
• Lanzetti L, Margaria V, Melander F, et al. (2007). "Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells". J. Biol. Chem. 282 (20): 15258–70. doi: 10.1074/jbc.M700914200 . PMID   17371873.
• Yuan K, Hu H, Guo Z, et al. (2007). "Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression". J. Biol. Chem. 282 (37): 27414–23. doi: 10.1074/jbc.M703555200 . PMID   17623655.