MTMR9

Last updated
MTMR9
Identifiers
Aliases MTMR9 , C8orf9, LIP-STYX, MTMR8, myotubularin related protein 9
External IDs OMIM: 606260; MGI: 2442842; HomoloGene: 9148; GeneCards: MTMR9; OMA:MTMR9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015458

NM_177594

RefSeq (protein)

NP_056273

NP_808262

Location (UCSC) Chr 8: 11.28 – 11.33 Mb Chr 14: 63.76 – 63.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene. [5] [6] [7] [8]

Contents

Function

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [8]

Interactions

MTMR9 has been shown to interact with MTMR6. [7]

References

  1. 1 2 3 ENSG00000285032 GRCh38: Ensembl release 89: ENSG00000104643, ENSG00000285032 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035078 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC (Jul 2001). "Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23". Genomics. 75 (1–3): 6–8. doi:10.1006/geno.2001.6591. PMID   11472061.
  6. Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E, Arndt S, Simmons A, Lovett M, Hide W, Ramsay M, Reichwald K, Zimmermann W, Rosenthal A (Mar 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi: 10.1038/sj.ejhg.5200750 . PMID   11896452.
  7. 1 2 Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. Bibcode:2003PNAS..100.9768M. doi: 10.1073/pnas.1333958100 . PMC   187840 . PMID   12890864.
  8. 1 2 "Entrez Gene: MTMR9 myotubularin related protein 9".

Further reading