MTMR9

Last updated
MTMR9
Identifiers
Aliases MTMR9 , C8orf9, LIP-STYX, MTMR8, myotubularin related protein 9
External IDs OMIM: 606260 MGI: 2442842 HomoloGene: 9148 GeneCards: MTMR9
Gene location (Human)
Ideogram human chromosome 8.svg
Chr. Chromosome 8 (human) [1]
Human chromosome 8 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 8p23.1Start11,284,816 bp [1]
End11,328,146 bp [1]
RNA expression pattern
PBB GE MTMR9 213278 at fs.png

PBB GE MTMR9 204837 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015458

NM_177594

RefSeq (protein)

NP_056273

NP_808262

Location (UCSC) Chr 8: 11.28 – 11.33 Mb Chr 14: 63.52 – 63.54 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene. [5] [6] [7] [8]

Contents

Function

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. [8]

Interactions

MTMR9 has been shown to interact with MTMR6. [7]

Related Research Articles

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WHSC2

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FUSIP1

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PHF10

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BTBD2

BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.

MEAF6

Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene.

COG3

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.

MTMR2

Myotubularin-related protein 2 also known as phosphatidylinositol-3,5-bisphosphate 3-phosphatase or phosphatidylinositol-3-phosphate phosphatase is a protein that in humans is encoded by the MTMR2 gene.

LRRC8D

Leucine-rich repeat-containing protein 8D is a protein that in humans is encoded by the LRRC8D gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8E, is a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.

OSBPL11

Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene.

REEP2 Protein-coding gene in humans

Receptor expression-enhancing protein 2 is a protein that in humans is encoded by the REEP2 gene.

DIXDC1

Dixin is a protein that in humans is encoded by the DIXDC1 gene. When active it stops cancer metastasis due to extreme stickiness, both in vitro and in vivo.

UBXD5

UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.

AVPI1

Arginine vasopressin-induced protein 1 is a protein that in humans is encoded by the AVPI1 gene.

ISCA1

Iron-sulfur cluster assembly 1 homolog, mitochondrial is an evolutionarily highly conserved protein for the biogenesis of iron-sulfur cluster across species. In humans it is encoded by the ISCA1 gene.

CALN1

Calcium-binding protein 8 is a protein that in humans is encoded by the CALN1 gene. Alternative splicing results in multiple transcript variants.

RUNDC3A

RUN domain-containing protein 3A is a protein that in humans is encoded by the RUNDC3A gene.

C19orf25

UPF0449 protein C19orf25 is a protein that in humans is encoded by the C19orf25 gene.

C12orf43

Uncharacterized protein C12orf43 is a protein that in humans is encoded by the C12orf43 gene.

MTMR14

Myotubularin related protein 14 also known as MTMR14 is a protein which in humans is encoded by the MTMR14 gene.

References

  1. 1 2 3 ENSG00000285032 GRCh38: Ensembl release 89: ENSG00000104643, ENSG00000285032 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035078 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC (Jul 2001). "Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23". Genomics. 75 (1–3): 6–8. doi:10.1006/geno.2001.6591. PMID   11472061.
  6. Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E, Arndt S, Simmons A, Lovett M, Hide W, Ramsay M, Reichwald K, Zimmermann W, Rosenthal A (Mar 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi: 10.1038/sj.ejhg.5200750 . PMID   11896452.
  7. 1 2 Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. doi:10.1073/pnas.1333958100. PMC   187840 . PMID   12890864.
  8. 1 2 "Entrez Gene: MTMR9 myotubularin related protein 9".

Further reading