Ribonuclease Z

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TRNase Z
Identifiers
EC no. 3.1.26.11
CAS no. 98148-84-6
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NCBI proteins

TRNase Z (EC 3.1.26.11, 3 tRNase, tRNA 3 endonuclease, RNase Z, 3' tRNase) is an enzyme [1] [2] [3] [4] [5] [6] [7] that, among other things, catalyses the reactions involved in the maturation of tRNAs. Here, it endonucleolytically cleaves the RNA and removes extra 3' nucleotides from the tRNA precursor, generating the 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. Similarly, it processes tRNA-like molecules such as mascRNA. [8]

References

  1. ↑ Schiffer S, Rösch S, Marchfelder A (June 2002). "Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes". The EMBO Journal. 21 (11): 2769–77. doi:10.1093/emboj/21.11.2769. PMC   126033 . PMID   12032089.
  2. ↑ Mayer M, Schiffer S, Marchfelder A (February 2000). "tRNA 3' processing in plants: nuclear and mitochondrial activities differ". Biochemistry. 39 (8): 2096–105. doi:10.1021/bi992253e. PMID   10684660.
  3. ↑ Schiffer S, Helm M, Théobald-Dietrich A, Giegé R, Marchfelder A (July 2001). "The plant tRNA 3' processing enzyme has a broad substrate spectrum". Biochemistry. 40 (28): 8264–72. doi:10.1021/bi0101953. PMID   11444972.
  4. ↑ Kunzmann A, Brennicke A, Marchfelder A (January 1998). "5' end maturation and RNA editing have to precede tRNA 3' processing in plant mitochondria". Proceedings of the National Academy of Sciences of the United States of America. 95 (1): 108–13. Bibcode:1998PNAS...95..108K. doi: 10.1073/pnas.95.1.108 . PMC   18142 . PMID   9419337.
  5. ↑ Mörl M, Marchfelder A (January 2001). "The final cut. The importance of tRNA 3'-processing". EMBO Reports. 2 (1): 17–20. doi:10.1093/embo-reports/kve006. PMC   1083803 . PMID   11252717.
  6. ↑ Minagawa A, Takaku H, Takagi M, Nashimoto M (April 2004). "A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima". The Journal of Biological Chemistry. 279 (15): 15688–97. doi: 10.1074/jbc.M313951200 . PMID   14749326.
  7. ↑ Takaku H, Minagawa A, Takagi M, Nashimoto M (May 2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease". Nucleic Acids Research. 31 (9): 2272–8. doi:10.1093/nar/gkg337. PMC   154223 . PMID   12711671.
  8. ↑ Wilusz JE, Freier SM, Spector DL (November 2008). "3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA". Cell. 135 (5): 919–32. doi:10.1016/j.cell.2008.10.012. PMC   2722846 . PMID   19041754.
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