RNASEH1

Last updated
RNASEH1
PDB 2qk9 EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNASEH1 , H1RNA, RNH1, PEOB2, ribonuclease H1
External IDs OMIM: 604123 MGI: 1335073 HomoloGene: 2202 GeneCards: RNASEH1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286865
NM_011275

RefSeq (protein)

NP_001273794
NP_035405

Location (UCSC) Chr 2: 3.54 – 3.56 Mb Chr 12: 28.7 – 28.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. [5] [6] [7] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.

Contents

Related Research Articles

<span class="mw-page-title-main">Ribonuclease H</span> Enzyme family

Ribonuclease H is a family of non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate via a hydrolytic mechanism. Members of the RNase H family can be found in nearly all organisms, from bacteria to archaea to eukaryotes.

<span class="mw-page-title-main">Exonuclease 1</span> Protein-coding gene in the species Homo sapiens

Exonuclease 1 is an enzyme that in humans is encoded by the EXO1 gene.

<span class="mw-page-title-main">SFRS3</span> Protein-coding gene in the species Homo sapiens

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

<span class="mw-page-title-main">EIF2S2</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

<span class="mw-page-title-main">HNRNPL</span> Protein-coding gene in the species Homo sapiens

Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.

<span class="mw-page-title-main">RNH1</span> Protein-coding gene in the species Homo sapiens

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.

<span class="mw-page-title-main">KHSRP</span> Protein-coding gene in the species Homo sapiens

Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene.

<span class="mw-page-title-main">POP1 (gene)</span> Protein-coding gene in the species Homo sapiens

Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene.

<span class="mw-page-title-main">POP5</span> Protein-coding gene in the species Homo sapiens

Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene.

<span class="mw-page-title-main">Exosome component 4</span> Protein-coding gene in the species Homo sapiens

Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex.

<span class="mw-page-title-main">MPZL1</span> Protein-coding gene in the species Homo sapiens

Myelin protein zero-like protein 1 is a protein that in humans is encoded by the MPZL1 gene.

<span class="mw-page-title-main">BAG2</span> Protein-coding gene in the species Homo sapiens

BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene.

<span class="mw-page-title-main">PTPN18</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

<span class="mw-page-title-main">GNG3</span> Protein-coding gene in the species Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

<span class="mw-page-title-main">Heat-responsive protein 12</span> Protein-coding gene in the species Homo sapiens

Ribonuclease UK114 is an enzyme that in humans is encoded by the HRSP12 gene.

<span class="mw-page-title-main">CTDSPL</span> Protein-coding gene in the species Homo sapiens

CTD small phosphatase-like protein is an enzyme that in humans is encoded by the CTDSPL gene.

<span class="mw-page-title-main">MRPS7</span> Protein-coding gene in the species Homo sapiens

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

<span class="mw-page-title-main">ZNF143</span> Protein-coding gene

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

RNA extraction is the purification of RNA from biological samples. This procedure is complicated by the ubiquitous presence of ribonuclease enzymes in cells and tissues, which can rapidly degrade RNA. Several methods are used in molecular biology to isolate RNA from samples, the most common of these is guanidinium thiocyanate-phenol-chloroform extraction. The filter paper based lysis and elution method features high throughput capacity.

<span class="mw-page-title-main">RNASEH2C</span> Protein-coding gene in the species Homo sapiens

Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits, and degrades the RNA of RNA:DNA hybrids.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171865 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020630 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ribonuclease H1".
  6. ten Asbroek AL, van Groenigen M, Jakobs ME, Koevoets C, Janssen B, Baas F (June 2002). "Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome". Genomics. 79 (6): 818–23. doi:10.1006/geno.2002.6776. PMID   12036296.
  7. Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (October 2007). "Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription". Mol. Cell. 28 (2): 264–76. doi: 10.1016/j.molcel.2007.08.015 . PMID   17964265.

Further reading