ORC4

ORC4
Identifiers
Aliases	ORC4 , ORC4L, ORC4P, origin recognition complex subunit 4
External IDs	OMIM: 603056 MGI: 1347043 HomoloGene: 8059 GeneCards: ORC4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	148,021,604 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	48,840,289 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; oocyte; ; islet of Langerhans; ; ganglionic eminence; ; kidney tubule; ; bronchial epithelial cell; ; corpus callosum; ; endothelial cell; ; right uterine tube; ; right ventricle;
	Top expressed in
	otic placode; ; saccule; ; spermatocyte; ; superior frontal gyrus; ; thymus; ; morula; ; neural tube; ; secondary oocyte; ; medullary collecting duct; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; DNA binding ; DNA replication origin binding ; protein binding ; ATP binding ;
Cellular component	nuclear origin of replication recognition complex ; nucleolus ; origin recognition complex ; nucleus ; nucleoplasm ; cytosol ;
Biological process	G1 phase ; DNA replication ; DNA replication initiation ; G1/S transition of mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	5000
	26428
	ENSG00000115947
	ENSMUSG00000026761
	O43929
	O88708
NM_001190879 ; NM_001190881 ; NM_001190882 ; NM_002552 ; NM_181741 ;
	NM_181742 ; NM_001374270 ; NM_001374272
	NM_001177313 ; NM_011958 ; NM_001355296
NP_001177808 ; NP_001177810 ; NP_001177811 ; NP_002543 ; NP_859525 ;
	NP_859526 ; NP_001361199 ; NP_001361201
	NP_001170784 ; NP_036088 ; NP_001342225
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 27, 2024

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.^[5]^[6]^[7]

Function

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.^[7]

Interactions

ORC4 has been shown to interact with:

Related Research Articles

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.

Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA is central for the duplication of a cell and is necessary for the maintenance of the eukaryotic genome.

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. It represents subunit Med30 of the Mediator complex and is metazoan-specific, having no homologues in yeasts.

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.

Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115947 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026761 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi: 10.1074/jbc.272.45.28247 . PMID 9353276.
↑ Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.
1 2 "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".
1 2 3 4 5 6 7 8 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
1 2 3 Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi: 10.1074/jbc.M103078200 . PMID 11395502.
1 2 Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . PMID 11323433.
↑ Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi: 10.1016/s0896-6273(00)80752-7 . PMID 10402192. S2CID 781511.
↑ Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi: 10.1074/jbc.273.42.27137 . PMID 9765232.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi: 10.1074/jbc.273.49.32421 . PMID 9829972.
Springer J, Kneissl M, Pütter V, Grummt F (Aug 1999). "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex". Chromosoma. 108 (4): 243–9. doi:10.1007/s004120050374. PMID 10460412. S2CID 8689588.
Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The EMBO Journal. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637 . PMID 10523313.
Thome KC, Dhar SK, Quintana DG, Delmolino L, Shahsafaei A, Dutta A (Nov 2000). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". The Journal of Biological Chemistry. 275 (45): 35233–41. doi: 10.1074/jbc.M005765200 . PMID 10954718.
Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . PMID 11323433.
Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi: 10.1074/jbc.M103078200 . PMID 11395502.
Okuno Y, McNairn AJ, den Elzen N, Pines J, Gilbert DM (Aug 2001). "Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle". The EMBO Journal. 20 (15): 4263–77. doi:10.1093/emboj/20.15.4263. PMC 149150 . PMID 11483529.
Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (Jul 2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. Bibcode:2004Sci...305...86R. doi:10.1126/science.1097639. PMID 15232106. S2CID 20936301.
Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex". Biochemistry. 44 (21): 7885–96. doi:10.1021/bi047327n. PMID 15910003.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115947 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9353276-5] 1 2 Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi: 10.1074/jbc.272.45.28247 . PMID 9353276.

[pmid9691185-6] Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID 9691185. S2CID 46878915.

[entrez-7] 1 2 "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".

[pmid12614612-8] 1 2 3 4 5 6 7 8 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid11395502-9] 1 2 3 Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi: 10.1074/jbc.M103078200 . PMID 11395502.

[pmid11323433-10] 1 2 Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . PMID 11323433.

[pmid10402192-11] Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi: 10.1016/s0896-6273(00)80752-7 . PMID 10402192. S2CID 781511.

[pmid9765232-12] Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi: 10.1074/jbc.273.42.27137 . PMID 9765232.

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ORC4

Contents

Function

Interactions

Related Research Articles

References

Further reading