ORC6

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex subunit 6 (ORC6)
Origin recognition complex subunit 6 (ORC6)
Identifiers
Symbol	ORC6
Pfam	PF05460
InterPro	IPR008721
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ORC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3M03
Identifiers
Aliases	ORC6 , ORC6L, origin recognition complex subunit 6
External IDs	OMIM: 607213 MGI: 1929285 HomoloGene: 8635 GeneCards: ORC6
Gene location (Human)
Chr.	Chromosome 16 (human)
End	46,698,394 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	86,034,907 bp
RNA expression pattern
	Top expressed in
	oocyte; ; endothelial cell; ; secondary oocyte; ; embryo; ; ganglionic eminence; ; cancellous bone; ; sperm; ; bone marrow; ; thymus; ; bone marrow cells;
	Top expressed in
	secondary oocyte; ; otic placode; ; maxillary prominence; ; somite; ; morula; ; primitive streak; ; endocardial cushion; ; hand; ; abdominal wall; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; protein binding ; DNA replication origin binding ;
Cellular component	nucleus ; membrane ; nucleoplasm ; origin recognition complex ; fibrillar center ; nuclear origin of replication recognition complex ;
Biological process	G1 phase ; DNA replication ; DNA replication initiation ; negative regulation of cell division ; G1/S transition of mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	23594
	56452
	ENSG00000091651
	ENSMUSG00000031697
	Q9Y5N6
	Q9WUJ8
	NM_014321
	NM_001163791 ; NM_019716
	NP_055136
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.^[5]^[6]

Background

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.

Function

The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and ORC1 are loosely associated with the core complex consisting of ORC2, -3, -4 and -5. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.^[6]

Interactions

ORC6 has been shown to interact with MCM5,^[7] ORC2,^[7]^[8] Replication protein A1,^[7] ORC4,^[7] DBF4,^[7] ORC3,^[7]^[8] CDC45-related protein,^[7] MCM4 ^[7] and Cell division cycle 7-related protein kinase.^[7]

Related Research Articles

The origin of replication is a particular sequence in a genome at which replication is initiated. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes. This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses. Synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that control replication onset. Although the specific replication origin organization structure and recognition varies from species to species, some common characteristics are shared.

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.

In molecular biology, origin recognition complex (ORC) is a multi-subunit DNA binding complex that binds in all eukaryotes and archaea in an ATP-dependent manner to origins of replication. The subunits of this complex are encoded by the ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6 genes. ORC is a central component for eukaryotic DNA replication, and remains bound to chromatin at replication origins throughout the cell cycle.

Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA is central for the duplication of a cell and is necessary for the maintenance of the eukaryotic genome.

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

CDT1 is a protein that in humans is encoded by the CDT1 gene. It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.

CDC45 is a protein that in humans is encoded by the CDC45L gene.

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000091651 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031697 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dhar SK, Dutta A (Nov 2000). "Identification and characterization of the human ORC6 homolog". J Biol Chem. 275 (45): 34983–8. doi: 10.1074/jbc.M006069200 . PMID 10945994.
1 2 "Entrez Gene: ORC6L origin recognition complex, subunit 6 like (yeast)".
1 2 3 4 5 6 7 8 9 Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. England. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
1 2 Vashee, S; Simancek P; Challberg M D; Kelly T J (Jul 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. United States. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . ISSN 0021-9258. PMID 11323433.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Origin recognition complex (ORC6)

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000091651 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031697 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10945994-5] Dhar SK, Dutta A (Nov 2000). "Identification and characterization of the human ORC6 homolog". J Biol Chem. 275 (45): 34983–8. doi: 10.1074/jbc.M006069200 . PMID 10945994.

[entrez-6] 1 2 "Entrez Gene: ORC6L origin recognition complex, subunit 6 like (yeast)".

[pmid12614612-7] 1 2 3 4 5 6 7 8 9 Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. England. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.

[pmid11323433-8] 1 2 Vashee, S; Simancek P; Challberg M D; Kelly T J (Jul 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. United States. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . ISSN 0021-9258. PMID 11323433.

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