ORC3

ORC3
Identifiers
Aliases	ORC3 , LAT, LATHEO, ORC3L, origin recognition complex subunit 3
External IDs	OMIM: 604972 MGI: 1354944 HomoloGene: 8225 GeneCards: ORC3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,667,453 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	34,614,944 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; Achilles tendon; ; embryo; ; ganglionic eminence; ; Right adrenal gland; ; biceps brachii; ; Left adrenal gland; ; islet of Langerhans; ; sperm; ; right uterine tube;
	Top expressed in
	spermatocyte; ; maxillary prominence; ; mirror; ; secondary oocyte; ; interventricular septum; ; somite; ; ganglionic eminence; ; thymus; ; superior frontal gyrus; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; DNA replication origin binding ; protein binding ;
Cellular component	nuclear origin of replication recognition complex ; origin recognition complex ; nucleus ; nucleoplasm ; nuclear pre-replicative complex ; DNA replication preinitiation complex ; nuclear body ;
Biological process	G1 phase ; DNA replication ; neural precursor cell proliferation ; DNA replication initiation ; pre-replicative complex assembly involved in nuclear cell cycle DNA replication ; G1/S transition of mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	23595
	50793
	ENSG00000135336
	ENSMUSG00000040044
	Q9UBD5
	Q9JK30
	NM_001197259 ; NM_012381 ; NM_181837
	NM_001159563 ; NM_015824
	NP_001184188 ; NP_036513 ; NP_862820
	NP_001153035 ; NP_056639
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex (ORC) subunit 3 N-terminus
Origin recognition complex (ORC) subunit 3 N-terminus
Identifiers
Symbol	ORC3_N
Pfam	PF07034
InterPro	IPR010748
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Last updated March 04, 2023

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.^[5]^[6]^[7]

Function

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.^[7]

Interactions

ORC3 has been shown to interact with:

Related Research Articles

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

CDT1 is a protein that in humans is encoded by the CDT1 gene. It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

CDC45 is a protein that in humans is encoded by the CDC45L gene.

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.

<span class="mw-page-title-main">Cdc6</span>

Cdc6, or cell division cycle 6, is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae. It is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate S phase and mitosis. It is part of the pre-replicative complex (pre-RC) and is required for loading minichromosome maintenance (MCM) proteins onto the DNA, an essential step in the initiation of DNA synthesis. In addition, it is a member of the family of AAA+ ATPases and highly related to ORC1; both are the same protein in archaea.

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.

Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene.

Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135336 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040044 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi: 10.1074/jbc.273.49.32421 . PMID 9829972.
1 2 3 4 Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi: 10.1016/S0896-6273(00)80752-7 . PMID 10402192. S2CID 781511.
1 2 "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)".
1 2 3 4 5 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
1 2 3 Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi: 10.1074/jbc.M103078200 . PMID 11395502.
↑ Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.
1 2 3 4 Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . PMID 11323433.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Springer J, Nanda I, Hoehn K, Schmid M, Grummt F (2000). "Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex". Cytogenetics and Cell Genetics. 87 (3–4): 245–51. doi:10.1159/000015435. PMID 10702681. S2CID 29132152.
Thome KC, Dhar SK, Quintana DG, Delmolino L, Shahsafaei A, Dutta A (Nov 2000). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". The Journal of Biological Chemistry. 275 (45): 35233–41. doi: 10.1074/jbc.M005765200 . PMID 10954718.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . PMID 11323433.
Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi: 10.1074/jbc.M103078200 . PMID 11395502.
Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (Jul 2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. Bibcode:2004Sci...305...86R. doi:10.1126/science.1097639. PMID 15232106. S2CID 20936301.
Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex". Biochemistry. 44 (21): 7885–96. doi:10.1021/bi047327n. PMID 15910003.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135336 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040044 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9829972-5] Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi: 10.1074/jbc.273.49.32421 . PMID 9829972.

[pmid10402192-6] 1 2 3 4 Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi: 10.1016/S0896-6273(00)80752-7 . PMID 10402192. S2CID 781511.

[entrez-7] 1 2 "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)".

[pmid12614612-8] 1 2 3 4 5 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid11395502-9] 1 2 3 Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi: 10.1074/jbc.M103078200 . PMID 11395502.

[pmid17525332-10] Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

[pmid11323433-11] 1 2 3 4 Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . PMID 11323433.

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ORC3

Contents

Function

Interactions

Related Research Articles

References

Further reading