POLD2

POLD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E0J
Identifiers
Aliases	POLD2 , DNA polymerase delta 2, accessory subunit
External IDs	OMIM: 600815; MGI: 1097163; HomoloGene: 4538; GeneCards: POLD2; OMA:POLD2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p13 Start 44,114,681 bp [1] End 44,124,358 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 5,822,180 bp [2] End 5,828,292 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube apex of heart ventricular zone right lobe of liver right auricle of heart body of pancreas left ovary right hemisphere of cerebellum skin of abdomen muscle of thigh Top expressed in yolk sac genital tubercle ventricular zone internal carotid artery epiblast embryo mandibular prominence maxillary prominence external carotid artery embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding DNA-directed DNA polymerase activity Cellular component nucleoplasm nucleus delta DNA polymerase complex Biological process nucleotide-excision repair, DNA gap filling DNA replication translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision telomere maintenance nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair DNA strand elongation involved in DNA replication cellular response to DNA damage stimulus telomere maintenance via semi-conservative replication DNA mismatch repair DNA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5425 18972 Ensembl ENSG00000106628 ENSMUSG00000020471 UniProt P49005 O35654 RefSeq (mRNA) NM_001127218 NM_001256879 NM_006230 NM_008894 NM_001361942 RefSeq (protein) NP_001120690 NP_001243808 NP_006221 NP_032920 NP_001348871 Location (UCSC) Chr 7: 44.11 – 44.12 Mb Chr 11: 5.82 – 5.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. ^{[5] [6]} It is a component of the DNA polymerase delta complex.

Interactions

POLD2 has been shown to interact with PCNA. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000106628 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020471 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics. 29 (1): 179–86. doi: 10.1006/geno.1995.1229 . PMID   8530069.
6. "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
7. Lu X, Tan Cheng-Keat, Zhou Jin-Qiu, You Min, Carastro L Michael, Downey Kathleen M, So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27). United States: 24340–5. doi: 10.1074/jbc.M200065200 . ISSN   0021-9258. PMID   11986310.

Further reading

• Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)". Genomics. 44 (1): 45–51. doi:10.1006/geno.1997.4838. PMID   9286699.
• Hisama FM, Chen YH, Meyn MS, Oshima J, Weissman SM (2000). "WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts". Cancer Res. 60 (9): 2372–6. PMID   10811112.
• Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry. 39 (24): 7245–54. doi:10.1021/bi0000871. PMID   10852724.
• Perez A, Leon A, Lee MY (2000). "Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta". Biochim. Biophys. Acta. 1493 (1–2): 231–6. doi:10.1016/s0167-4781(00)00153-6. PMID   10978529.
• Szekely AM, Chen YH, Zhang C, Oshima J, Weissman SM (2000). "Werner protein recruits DNA polymerase δ to the nucleolus". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365–70. Bibcode:2000PNAS...9711365S. doi: 10.1073/pnas.97.21.11365 . PMC   17206 . PMID   11027336.
• He H, Tan CK, Downey KM, So AG (2001). "A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi: 10.1073/pnas.221452098 . PMC   59753 . PMID   11593007.
• Lu X, Tan CK, Zhou JQ, You M, Carastro LM, Downey KM, So AG (2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27): 24340–5. doi: 10.1074/jbc.M200065200 . PMID   11986310.
• Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi: 10.1074/jbc.M206194200 . PMID   12171929.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J. Biol. Chem. 278 (12): 10041–7. doi: 10.1074/jbc.M208694200 . PMID   12522211.
• Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Tsurimoto T, Shinozaki A, Yano M, Seki M, Enomoto T (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID   15670210. S2CID   24977510.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Overview of all the structural information available in the PDB for UniProt : P49005 (Human DNA polymerase delta subunit 2 (POLD2)) at the PDBe-KB .