DNA polymerase alpha subunit 2

Last updated
POLA2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLA2 , DNA polymerase alpha 2, accessory subunit
External IDs MGI: 99690 HomoloGene: 48121 GeneCards: POLA2
Orthologs
SpeciesHumanMouse
Entrez

23649

18969

Ensembl

ENSG00000014138

ENSMUSG00000024833

UniProt

Q14181

P33611

RefSeq (mRNA)

NM_002689

NM_001164057
NM_008893

RefSeq (protein)

NP_002680

NP_001157529
NP_032919

Location (UCSC) Chr 11: 65.26 – 65.31 Mb Chr 19: 5.99 – 6.01 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene. [5] [6] [7]

Contents

Interactions

POLA2 has been shown to interact with PARP1. [8]

See also

Related Research Articles

<span class="mw-page-title-main">Polymerase</span> Class of enzymes

A polymerase is an enzyme that synthesizes long chains of polymers or nucleic acids. DNA polymerase and RNA polymerase are used to assemble DNA and RNA molecules, respectively, by copying a DNA template strand using base-pairing interactions or RNA by half ladder replication.

DNA primase is an enzyme involved in the replication of DNA and is a type of RNA polymerase. Primase catalyzes the synthesis of a short RNA segment called a primer complementary to a ssDNA template. After this elongation, the RNA piece is removed by a 5' to 3' exonuclease and refilled with DNA.

<span class="mw-page-title-main">Proliferating cell nuclear antigen</span>

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.

<span class="mw-page-title-main">PARP1</span> Mammalian protein found in Homo sapiens

Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. It is the most abundant of the PARP family of enzymes, accounting for 90% of the NAD+ used by the family. PARP1 is mostly present in cell nucleus, but cytosolic fraction of this protein was also reported.

<span class="mw-page-title-main">Replication protein A1</span> Protein-coding gene in the species Homo sapiens

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.

<span class="mw-page-title-main">POLG</span> Protein-coding gene in the species Homo sapiens

DNA polymerase subunit gamma is an enzyme that in humans is encoded by the POLG gene. Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE).

<span class="mw-page-title-main">GTF3C2</span> Protein-coding gene in the species Homo sapiens

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.

<span class="mw-page-title-main">MCM10</span> Protein-coding gene in the species Homo sapiens

Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene. It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication.

<span class="mw-page-title-main">CDC45-related protein</span> Protein-coding gene in the species Homo sapiens

CDC45 is a protein that in humans is encoded by the CDC45L gene.

<span class="mw-page-title-main">GTF3C1</span> Protein-coding gene in the species Homo sapiens

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.

<span class="mw-page-title-main">PRIM2</span> Protein-coding gene in the species Homo sapiens

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.

<span class="mw-page-title-main">POLD3</span> Protein-coding gene in the species Homo sapiens

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.

<span class="mw-page-title-main">POLE3</span> Protein-coding gene in the species Homo sapiens

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.

<span class="mw-page-title-main">RBMS1</span> Protein-coding gene in the species Homo sapiens

RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.

<span class="mw-page-title-main">POLE2</span> Protein-coding gene in the species Homo sapiens

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.

<span class="mw-page-title-main">POLD4</span> Protein-coding gene in the species Homo sapiens

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.

<span class="mw-page-title-main">PrimPol</span> Protein-coding gene in the species Homo sapiens

PrimPol is a protein encoded by the PRIMPOL gene in humans. PrimPol is a eukaryotic protein with both DNA polymerase and DNA Primase activities involved in translesion DNA synthesis. It is the first eukaryotic protein to be identified with priming activity using deoxyribonucleotides. It is also the first protein identified in the mitochondria to have translesion DNA synthesis activities.

<span class="mw-page-title-main">PRIM1</span> Protein-coding gene in the species Homo sapiens

DNA primase small subunit is an enzyme that in humans is encoded by the PRIM1 gene.

<span class="mw-page-title-main">POLE4</span> Protein-coding gene in the species Homo sapiens

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.

<span class="mw-page-title-main">DNA polymerase alpha catalytic subunit</span> Protein-coding gene in the species Homo sapiens

DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000014138 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024833 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Collins KL, Russo AA, Tseng BY, Kelly TJ (Dec 1993). "The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication". EMBO J. 12 (12): 4555–66. doi:10.1002/j.1460-2075.1993.tb06144.x. PMC   413886 . PMID   8223465.
  6. ↑ Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (Jul 2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC   55767 . PMID   11433027.
  7. ↑ "Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit)".
  8. ↑ Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (Apr 1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. doi:10.1093/nar/26.8.1891. PMC   147507 . PMID   9518481.

Further reading



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