POLE3

POLE3
Identifiers
Aliases	POLE3 , CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDs	OMIM: 607267; MGI: 1933378; HomoloGene: 9694; GeneCards: POLE3; OMA:POLE3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q32 Start 113,407,235 bp [1] End 113,410,675 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B3 Start 62,440,886 bp [2] End 62,443,305 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gastrocnemius muscle granulocyte monocyte human penis ganglionic eminence muscle of thigh rectum ventricular zone bone marrow Top expressed in spermatocyte ventricular zone yolk sac secondary oocyte zygote fetal liver hematopoietic progenitor cell seminiferous tubule morula molar mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding DNA-directed DNA polymerase activity nucleotidyltransferase activity protein binding protein heterodimerization activity histone acetyltransferase activity Cellular component epsilon DNA polymerase complex nucleus nucleoplasm Biological process DNA replication histone H3 acetylation DNA biosynthetic process G1/S transition of mitotic cell cycle cellular response to DNA damage stimulus CENP-A containing chromatin assembly cellular response to gamma radiation DNA replication initiation telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54107 59001 Ensembl ENSG00000148229 ENSMUSG00000028394 UniProt Q9NRF9 Q9JKP7 RefSeq (mRNA) NM_001278255 NM_017443 NM_021498 RefSeq (protein) NP_001265184 NP_059139 NP_067473 Location (UCSC) Chr 9: 113.41 – 113.41 Mb Chr 4: 62.44 – 62.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene. ^{[5] [6] [7]}

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM] ^[7]

Interactions

POLE3 has been shown to interact with SMARCA5. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi: 10.1074/jbc.M002548200 . PMID   10801849.
6. Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC   313940 . PMID   10880450.
7. "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Bolognese F, Imbriano C, Caretti G, Mantovani R (2000). "Cloning and characterization of the histone-fold proteins YBL1 and YCL1". Nucleic Acids Res. 28 (19): 3830–8. doi:10.1093/nar/28.19.3830. PMC   110757 . PMID   11000277.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC   206465 . PMID   14500819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.