| POLE2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | POLE2 , DPE2, polymerase (DNA) epsilon 2, accessory subunit, DNA polymerase epsilon 2, accessory subunit | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602670 MGI: 1197514 HomoloGene: 2015 GeneCards: POLE2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene. [5] [6] [7]
XPB is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.
UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.
Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.
Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.
General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.
DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene. This polymerase plays a key role in one of the three major double strand break repair pathways: theta-mediated end joining (TMEJ). Most double-strand breaks are repaired by non-homologous end joining (NHEJ) or homology directed repair (HDR). However, in some contexts, NHEJ and HR are insufficient and TMEJ is the only solution to repair the break. TMEJ is often described as alternative NHEJ, but differs in that it lacks a requirement for the Ku heterodimer, and it can only act on resected DNA ends. Following annealing of short regions on the DNA overhangs, DNA polymerase theta catalyzes template-dependent DNA synthesis across the broken ends, stabilizing the paired structure.
DNA polymerase subunit gamma-2, mitochondrial is a protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.
Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene. It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication.
Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.
DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. It is a component of the DNA polymerase delta complex.
DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.
General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.
DNA polymerase eta, is a protein that in humans is encoded by the POLH gene.
RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.
DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.
DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the POLE gene. It is the central catalytic subunit of DNA polymerase epsilon.
DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.
Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.
DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene.
 | This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it. |
