SAP18

SAP18
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2HDE
Identifiers
Aliases	SAP18 , 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18
External IDs	OMIM: 602949 MGI: 3704317 HomoloGene: 4289 GeneCards: SAP18
Gene location (Human)
Chr.	Chromosome 13 (human)
End	21,149,084 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	96,552,762 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; right ventricle; ; tendon; ; corpus epididymis; ; Achilles tendon; ; caput epididymis; ; bronchial epithelial cell; ; biceps brachii; ; cavity of mouth; ; spongy bone;
	Top expressed in
	yolk sac; ; neural tube; ; stomach; ; mirror; ; proximal tubule; ; limb; ; ileum; ; quadriceps femoris muscle; ; lip; ; jejunum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity ; protein binding ; histone deacetylase activity ; RNA binding ;
Cellular component	histone deacetylase complex ; nuclear speck ; exon-exon junction complex ; nucleoplasm ; ASAP complex ; nucleus ; cytoplasm ; cytosol ; nuclear body ;
Biological process	regulation of transcription, DNA-templated ; regulation of transcription by RNA polymerase II ; mRNA processing ; regulation of alternative mRNA splicing, via spliceosome ; transcription, DNA-templated ; negative regulation of mRNA splicing, via spliceosome ; RNA splicing ; positive regulation of apoptotic process ; negative regulation of nucleic acid-templated transcription ; histone deacetylation ;
	Sources:Amigo / QuickGO
Orthologs
	10284
	100041953
	ENSG00000150459
	ENSMUSG00000061104
	O00422
	n/a
	NM_005870 ; NM_001366643
	NM_001142441
	NP_005861 ; NP_001353572
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 06, 2023

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.^[5]^[6]

Function

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.^[6] Additionally, SAP18s splice variants are implicated in apoptotic cycles.^[7]

Interactions

SAP18 has been shown to interact with

POLE2,^[8]^[9] and
RGS10.^[10]

Related Research Articles

Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.

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Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression. NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT) or T₃ receptor-associating cofactor 1 (TRAC-1).

Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. It belongs to the histone deacetylase class of enzymes responsible for the removal of acetyl groups from lysine residues at the N-terminal region of the core histones. As such, it plays an important role in gene expression by facilitating the formation of transcription repressor complexes and for this reason is often considered an important target for cancer therapy.

Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.

Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.

<span class="mw-page-title-main">HDAC4</span>

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.

Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene.

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.

MAD protein is a protein that in humans is encoded by the MXD1 gene.

Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is crucial in embryonic development. There are several homologues of Sufu, found in a wide variety of organisms.

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000150459 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061104 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi: 10.1016/S0092-8674(00)80216-0 . PMID 9150135.
1 2 "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa".
↑ Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Elela SA, Prinos P, Chabot B (March 2012). "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators". Molecular and Cellular Biology. 32 (5): 954–67. doi:10.1128/MCB.06130-11. PMC 3295189 . PMID 22203037.
↑ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (March 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". Journal of Biochemistry. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
↑ Cheng SY, Bishop JM (April 2002). "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5442–7. Bibcode:2002PNAS...99.5442C. doi: 10.1073/pnas.082096999 . PMC 122788 . PMID 11960000.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

External links

SAP18 human gene location in the UCSC Genome Browser .
SAP18 human gene details in the UCSC Genome Browser .

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000150459 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061104 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9150135-5] Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi: 10.1016/S0092-8674(00)80216-0 . PMID 9150135.

[entrez-6] 1 2 "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa".

[pmid22203037-7] Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Elela SA, Prinos P, Chabot B (March 2012). "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators". Molecular and Cellular Biology. 32 (5): 954–67. doi:10.1128/MCB.06130-11. PMC 3295189 . PMID 22203037.

[pmid11872158-8] Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (March 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". Journal of Biochemistry. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

[pmid11960000-9] Cheng SY, Bishop JM (April 2002). "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5442–7. Bibcode:2002PNAS...99.5442C. doi: 10.1073/pnas.082096999 . PMC 122788 . PMID 11960000.

[pmid17353931-10] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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