Inositol monophosphatase 2

IMPA2
Available structures PDB Ortholog search: A0A6I8PI91 PDBe A0A6I8PI91 RCSB List of PDB id codes 2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
Identifiers
Aliases	IMPA2 , inositol monophosphatase 2
External IDs	OMIM: 605922; MGI: 2149728; HomoloGene: 22799; GeneCards: IMPA2; OMA:IMPA2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.21 Start 11,981,025 bp [1] End 12,030,877 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of abdomen gastrocnemius muscle skin of leg muscle of thigh human kidney vulva skin of thigh Skeletal muscle tissue of rectus abdominis mucosa of transverse colon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function inositol monophosphate 1-phosphatase activity inositol monophosphate phosphatase activity hydrolase activity protein binding protein homodimerization activity metal ion binding inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity Cellular component cytoplasm cytosol Biological process phosphate-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process inositol metabolic process inositol biosynthetic process signal transduction inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3613 114663 Ensembl ENSG00000141401 n/a UniProt O14732 Q91UZ5 RefSeq (mRNA) NM_014214 NM_053261 RefSeq (protein) NP_055029 NP_444491 Location (UCSC) Chr 18: 11.98 – 12.03 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene. ^{[4] [5]} IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000141401 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID   9322233. S2CID   24336959.
5. "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2".
6. Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi: 10.1074/jbc.M604474200 . PMID   17068342.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Yoshikawa T, Padigaru M, Karkera JD, Sharma M, Berrettini WH, Esterling LE, Detera-Wadleigh SD (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)". Mol. Psychiatry. 5 (2): 165–71. doi:10.1038/sj.mp.4000688. PMID   10822344. S2CID   25662931.
• Sjøholt G, Gulbrandsen AK, Løvlie R, Berle JØ, Molven A, Steen VM (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients". Mol. Psychiatry. 5 (2): 172–80. doi:10.1038/sj.mp.4000681. PMID   10822345. S2CID   21428994.
• Yoon IS, Li PP, Siu KP, Kennedy JL, Cooke RG, Parikh SV, Warsh JJ (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder". Mol. Psychiatry. 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID   11673796. S2CID   26050322.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Azzouz TN, Schumperli D (2004). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA. 9 (12): 1532–41. doi:10.1261/rna.5143303. PMC   1370506 . PMID   14624008.
• Sjøholt G, Ebstein RP, Lie RT, Berle JØ, Mallet J, Deleuze JF, Levinson DF, Laurent C, Mujahed M (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry. 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID   14699425. S2CID   28747842.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nakayama J, Yamamoto N, Hamano K, Iwasaki N, Ohta M, Nakahara S, Matsui A, Noguchi E, Arinami T (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18". Neurology. 63 (10): 1803–7. doi:10.1212/01.wnl.0000144499.34164.e0. PMID   15557493. S2CID   20201724.
• Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi: 10.1074/jbc.M604474200 . PMID   17068342.
• Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription". Neuropsychopharmacology. 32 (8): 1727–37. doi: 10.1038/sj.npp.1301307 . PMID   17251911.
• Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, Hanawa-Suetsugu K, Yoshikawa T, Shirouzu M (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures". Proteins. 67 (3): 732–42. doi:10.1002/prot.21299. PMID   17340635. S2CID   46602105.
• Blair MA, Ma S, Abou-Khalil B, Hedera P (2007). "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients". Eur. J. Neurol. 14 (4): 424–7. doi:10.1111/j.1468-1331.2007.01702.x. PMID   17388992. S2CID   36906656.

External links

• Overview of all the structural information available in the PDB for UniProt : O14732 (Human Inositol monophosphatase 2) at the PDBe-KB .