Inositol monophosphatase 2

IMPA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
Identifiers
Aliases	IMPA2 , inositol monophosphatase 2
External IDs	OMIM: 605922 MGI: 2149728 HomoloGene: 22799 GeneCards: IMPA2
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.21 Start 11,981,025 bp [1] End 12,030,877 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of abdomen gastrocnemius muscle kidney vulva human penis vastus lateralis muscle gastric mucosa gums kidney tubule n/a More reference expression data BioGPS n/a
Gene ontology Molecular function inositol monophosphate 1-phosphatase activity inositol monophosphate phosphatase activity hydrolase activity protein binding protein homodimerization activity metal ion binding inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity Cellular component cytoplasm cytosol Biological process phosphate-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process inositol metabolic process inositol biosynthetic process signal transduction inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3613 114663 Ensembl ENSG00000141401 n/a UniProt O14732 Q91UZ5 RefSeq (mRNA) NM_014214 NM_053261 RefSeq (protein) NP_055029 NP_444491 Location (UCSC) Chr 18: 11.98 – 12.03 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene. ^{[4] [5]} IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000141401 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID   9322233. S2CID   24336959.
5. "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2".
6. Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi: 10.1074/jbc.M604474200 . PMID   17068342.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Yoshikawa T, Padigaru M, Karkera JD, et al. (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)". Mol. Psychiatry. 5 (2): 165–71. doi:10.1038/sj.mp.4000688. PMID   10822344. S2CID   25662931.
• Sjøholt G, Gulbrandsen AK, Løvlie R, et al. (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients". Mol. Psychiatry. 5 (2): 172–80. doi:10.1038/sj.mp.4000681. PMID   10822345. S2CID   21428994.
• Yoon IS, Li PP, Siu KP, et al. (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder". Mol. Psychiatry. 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID   11673796. S2CID   26050322.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Azzouz TN, Schumperli D (2004). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA. 9 (12): 1532–41. doi:10.1261/rna.5143303. PMC   1370506 . PMID   14624008.
• Sjøholt G, Ebstein RP, Lie RT, et al. (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry. 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID   14699425. S2CID   28747842.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nakayama J, Yamamoto N, Hamano K, et al. (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18". Neurology. 63 (10): 1803–7. doi:10.1212/01.wnl.0000144499.34164.e0. PMID   15557493. S2CID   20201724.
• Ohnishi T, Ohba H, Seo KC, et al. (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi: 10.1074/jbc.M604474200 . PMID   17068342.
• Ohnishi T, Yamada K, Ohba H, et al. (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription". Neuropsychopharmacology. 32 (8): 1727–37. doi: 10.1038/sj.npp.1301307 . PMID   17251911.
• Arai R, Ito K, Ohnishi T, et al. (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures". Proteins. 67 (3): 732–42. doi:10.1002/prot.21299. PMID   17340635. S2CID   46602105.
• Blair MA, Ma S, Abou-Khalil B, Hedera P (2007). "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients". Eur. J. Neurol. 14 (4): 424–7. doi:10.1111/j.1468-1331.2007.01702.x. PMID   17388992. S2CID   36906656.

External links

• Overview of all the structural information available in the PDB for UniProt : O14732 (Human Inositol monophosphatase 2) at the PDBe-KB .