Mitogen-activated protein kinase kinase kinase 6

MAP3K6
Identifiers
Aliases	MAP3K6 , ASK2, MAPKKK6, MEKK6, mitogen-activated protein kinase kinase kinase 6
External IDs	OMIM: 604468 MGI: 1855691 HomoloGene: 3435 GeneCards: MAP3K6
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,366,961 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,980,240 bp
RNA expression pattern
	Top expressed in
	right lung; ; skin of abdomen; ; upper lobe of left lung; ; left uterine tube; ; tibial nerve; ; canal of the cervix; ; gastric mucosa; ; right lobe of thyroid gland; ; ascending aorta; ; left coronary artery;
	Top expressed in
	secondary oocyte; ; superior surface of tongue; ; corneal stroma; ; hair follicle; ; lip; ; belly cord; ; esophagus; ; skin of back; ; aortic valve; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; protein serine/threonine kinase activity ; MAP kinase kinase kinase activity ; ATP binding ; magnesium ion binding ; metal ion binding ; kinase activity ;
Cellular component	intracellular anatomical structure ;
Biological process	protein phosphorylation ; phosphorylation ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	9064
	53608
	ENSG00000142733
	ENSMUSG00000028862
	O95382
	Q9WTR2
	NM_001297609 ; NM_004672 ; NM_145319
	NM_016693
	NP_001284538 ; NP_004663
	NP_057902
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. ^[5]

Function

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Related Research Articles

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene.

The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) as is a protein that in humans is encoded by the GPBAR1 gene.

Dual-specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.

MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.

Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene.

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.

Mitogen-activated protein kinase 12, also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

Mitogen-activated protein kinase 13, also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.

Mitogen-activated protein kinase kinase kinase kinase 3 is a protein that in humans is encoded by the MAP4K3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142733 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028862 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Mitogen-activated protein kinase kinase kinase 6" . Retrieved 2018-07-10.

Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H (March 2007). "Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1". J. Biol. Chem. 282 (10): 7522–31. doi: 10.1074/jbc.M607177200 . PMID 17210579.
Arning L, Monté D, Hansen W, Wieczorek S, Jagiello P, Akkad DA, Andrich J, Kraus PH, Saft C, Epplen JT (April 2008). "ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease". J. Mol. Med. 86 (4): 485–90. doi:10.1007/s00109-007-0299-6. PMID 18327563. S2CID 9535075.
Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M (April 2009). "Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression". Am. J. Pathol. 174 (4): 1553–63. doi:10.2353/ajpath.2009.080190. PMC 2671385 . PMID 19246638.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168 . PMID 20628086.
Gaston D, Hansford S, Oliveira C, Nightingale M, Pinheiro H, Macgillivray C, Kaurah P, Rideout AL, Steele P, Soares G, Huang WY, Whitehouse S, Blowers S, LeBlanc MA, Jiang H, Greer W, Samuels ME, Orr A, Fernandez CV, Majewski J, Ludman M, Dyack S, Penney LS, McMaster CR, Huntsman D, Bedard K (October 2014). "Germline mutations in MAP3K6 are associated with familial gastric cancer". PLOS Genet. 10 (10): e1004669. doi: 10.1371/journal.pgen.1004669 . PMC 4207611 . PMID 25340522.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142733 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028862 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mitogen-activated protein kinase kinase kinase 6" . Retrieved 2018-07-10.

[1]

[2]

[3]

[4]

[5]

Mitogen-activated protein kinase kinase kinase 6

Contents

Function

Related Research Articles

References

Further reading