KIAA1333

G2E3
Identifiers
Aliases	G2E3 , KIAA1333, PHF7B, G2/M-phase specific E3 ubiquitin protein ligase
External IDs	OMIM: 611299 MGI: 2444298 HomoloGene: 32362 GeneCards: G2E3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	30,620,064 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	51,423,769 bp
RNA expression pattern
	Top expressed in
	sperm; ; ganglionic eminence; ; pancreatic epithelial cell; ; Achilles tendon; ; tibialis anterior muscle; ; secondary oocyte; ; bone marrow cells; ; pancreatic ductal cell; ; thymus; ; stromal cell of endometrium;
	Top expressed in
	hand; ; superior cervical ganglion; ; primitive streak; ; maxillary prominence; ; medial ganglionic eminence; ; spermatid; ; cumulus cell; ; vas deferens; ; hair follicle; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity ; protein binding ; metal ion binding ; transferase activity ;
Cellular component	cytoplasm ; nucleolus ; nucleus ; cytosol ; intracellular membrane-bounded organelle ;
Biological process	multicellular organism development ; protein ubiquitination ; apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	55632
	217558
	ENSG00000092140
	ENSMUSG00000035293
	Q7L622
	Q5RJY2
	NM_001308097 ; NM_017769
	NM_001015099 ; NM_001167963 ; NM_001167964
	NP_001295026 ; NP_060239
	NP_001015099 ; NP_001161435 ; NP_001161436
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

G2/M phase-specific E3 ubiquitin-protein ligase is an enzyme that in humans is encoded by the G2E3 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000092140 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035293 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA, Crawford DF (Aug 2008). "G2E3 is a dual function ubiquitin ligase required for early embryonic development". J Biol Chem. 283 (32): 22304–15. doi: 10.1074/jbc.M803238200 . PMC 2494922 . PMID 18511420.
↑ Brooks WS, Banerjee S, Crawford DF (Feb 2007). "G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization". Exp Cell Res. 313 (4): 665–76. doi:10.1016/j.yexcr.2006.11.020. PMC 1876774 . PMID 17239372.
↑ "Entrez Gene: KIAA1333 KIAA1333".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID 10718198.
Crawford DF, Piwnica-Worms H (2001). "The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators". J. Biol. Chem. 276 (40): 37166–77. doi:10.1074/jbc.M103414200. PMID 11483598.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000092140 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035293 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18511420-5] Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR, Kesterson RA, Crawford DF (Aug 2008). "G2E3 is a dual function ubiquitin ligase required for early embryonic development". J Biol Chem. 283 (32): 22304–15. doi: 10.1074/jbc.M803238200 . PMC 2494922 . PMID 18511420.

[pmid17239372-6] Brooks WS, Banerjee S, Crawford DF (Feb 2007). "G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization". Exp Cell Res. 313 (4): 665–76. doi:10.1016/j.yexcr.2006.11.020. PMC 1876774 . PMID 17239372.

[entrez-7] "Entrez Gene: KIAA1333 KIAA1333".

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KIAA1333

Related Research Articles

References

Further reading