KIAA0101

PCLAF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D2G
Identifiers
Aliases	PCLAF , L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF, KIAA0101, PCNA clamp associated factor
External IDs	OMIM: 610696; MGI: 1915276; HomoloGene: 8829; GeneCards: PCLAF; OMA:PCLAF - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q22.31 Start 64,364,304 bp [1] End 64,387,687 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 C Start 65,797,519 bp [2] End 65,810,548 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone embryo ventricular zone ganglionic eminence bone marrow gingival epithelium thymus hair follicle bone marrow cells oral cavity Top expressed in yolk sac tail of embryo somite embryo ventricular zone genital tubercle embryo maxillary prominence mandibular prominence atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding protein binding Cellular component perinuclear region of cytoplasm nucleus nucleoplasm cytoplasm centrosome Biological process DNA replication translesion synthesis response to UV cellular response to DNA damage stimulus regulation of cell cycle DNA repair centrosome cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9768 68026 Ensembl ENSG00000166803 ENSMUSG00000040204 UniProt Q15004 Q9CQX4 RefSeq (mRNA) NM_001029989 NM_014736 NM_026515 RefSeq (protein) NP_001025160 NP_055551 NP_080791 Location (UCSC) Chr 15: 64.36 – 64.39 Mb Chr 9: 65.8 – 65.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PCNA-associated factor is a protein that in humans is encoded by the KIAA0101 gene. ^{[5] [6] [7]}

Interactions

KIAA0101 has been shown to interact with PCNA. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000166803 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040204 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi: 10.1038/sj.onc.1204113 . PMID   11313979.
6. Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID   16288740.
7. "Entrez Gene: KIAA0101 KIAA0101".

Further reading

• Shi L, Zhang SL, Li K, Hong Y, Wang Q, Li Y, Guo J, Fan WH, Zhang L, Cheng J (Feb 2008). "NS5ATP9, a gene up-regulated by HCV NS5A protein". Cancer Letters. 259 (2): 192–7. doi:10.1016/j.canlet.2007.10.029. PMID   18068894.
• Guo M, Li J, Wan D, Gu J (2006). "KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma". BMC Cancer. 6: 109. doi: 10.1186/1471-2407-6-109 . PMC   1483895 . PMID   16646990.
• Mizutani K, Onda M, Asaka S, Akaishi J, Miyamoto S, Yoshida A, Nagahama M, Ito K, Emi M (May 2005). "Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma". Cancer. 103 (9): 1785–90. doi: 10.1002/cncr.20988 . PMID   15789362.
• Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (Oct 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi: 10.1038/sj.onc.1207921 . PMID   15334068.
• Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID   7788527.