KIAA0101

PCLAF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D2G
Identifiers
Aliases	PCLAF , L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF, KIAA0101, PCNA clamp associated factor
External IDs	OMIM: 610696 MGI: 1915276 HomoloGene: 8829 GeneCards: PCLAF
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,387,687 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,810,548 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; embryo; ; ganglionic eminence; ; bone marrow; ; thymus; ; hair follicle; ; bone marrow cells; ; cavity of mouth; ; cardia; ; pancreatic ductal cell;
	Top expressed in
	yolk sac; ; somite; ; maxillary prominence; ; atrium; ; thymus; ; dermis; ; hand; ; optic recess; ; ganglionic eminence; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding ; protein binding ;
Cellular component	perinuclear region of cytoplasm ; nucleus ; nucleoplasm ; cytoplasm ; centrosome ;
Biological process	DNA replication ; translesion synthesis ; response to UV ; cellular response to DNA damage stimulus ; regulation of cell cycle ; DNA repair ; centrosome cycle ;
	Sources:Amigo / QuickGO
Orthologs
	9768
	68026
	ENSG00000166803
	ENSMUSG00000040204
	Q15004
	Q9CQX4
	NM_001029989 ; NM_014736
	NM_026515
	NP_001025160 ; NP_055551
	NP_080791
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

PCNA-associated factor is a protein that in humans is encoded by the KIAA0101 gene.^[5]^[6]^[7]

Interactions

KIAA0101 has been shown to interact with PCNA.^[5]

Related Research Articles

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA.

Cyclin D1 is a protein that in humans is encoded by the CCND1 gene.

Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. Joyce Taylor-Papadimitriou identified and characterised the antigen during her work with breast and ovarian tumors.

Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15^INK4b is a protein that is encoded by the CDKN2B gene in humans.

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

<span class="mw-page-title-main">Anaplastic lymphoma kinase</span> Protein-coding gene in the species Homo sapiens

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 is an enzyme that in humans is encoded by the ALK gene.

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.

Protein TFG is a protein that in humans is encoded by the TFG gene.

Tumor protein D52 is a protein that in humans is encoded by the TPD52 gene.

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. It is an important regulator of cardiac development and a marker of hippocampal neural stem cells.

ID4 is a protein coding gene. In humans, it encodes for the protein known as DNA-binding protein inhibitor ID-4. This protein is known to be involved in the regulation of many cellular processes during both prenatal development and tumorigenesis. This is inclusive of embryonic cellular growth, senescence, cellular differentiation, apoptosis, and as an oncogene in angiogenesis.

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.

Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.

Dishevelled binding antagonist of beta catenin 2 is a protein that in humans is encoded by the DACT2 gene.

Ras association domain family member 10 is a protein that in humans is encoded by the RASSF10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166803 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040204 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi: 10.1038/sj.onc.1204113 . PMID 11313979.
↑ Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.
↑ "Entrez Gene: KIAA0101 KIAA0101".

Shi L, Zhang SL, Li K, Hong Y, Wang Q, Li Y, Guo J, Fan WH, Zhang L, Cheng J (Feb 2008). "NS5ATP9, a gene up-regulated by HCV NS5A protein". Cancer Letters. 259 (2): 192–7. doi:10.1016/j.canlet.2007.10.029. PMID 18068894.
Guo M, Li J, Wan D, Gu J (2006). "KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma". BMC Cancer. 6: 109. doi: 10.1186/1471-2407-6-109 . PMC 1483895 . PMID 16646990.
Mizutani K, Onda M, Asaka S, Akaishi J, Miyamoto S, Yoshida A, Nagahama M, Ito K, Emi M (May 2005). "Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma". Cancer. 103 (9): 1785–90. doi: 10.1002/cncr.20988 . PMID 15789362.
Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (Oct 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi: 10.1038/sj.onc.1207921 . PMID 15334068.
Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID 7788527.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166803 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040204 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11313979-5] 1 2 Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi: 10.1038/sj.onc.1204113 . PMID 11313979.

[pmid16288740-6] Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.

[entrez-7] "Entrez Gene: KIAA0101 KIAA0101".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

KIAA0101

Contents

Interactions

Related Research Articles

References

Further reading