KIAA1967

Not to be confused with Deleted in Bladder Cancer 1 (DBC1).

CCAR2
Identifiers
Aliases	CCAR2 , DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2
External IDs	OMIM: 607359 MGI: 2444228 HomoloGene: 10910 GeneCards: CCAR2
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.3 Start 22,604,757 bp [1] End 22,620,964 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D2 Start 70,375,613 bp [2] End 70,391,260 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right uterine tube cerebellar hemisphere appendix stromal cell of endometrium sural nerve left uterine tube skin of abdomen prefrontal cortex anterior pituitary Top expressed in spermatocyte renal corpuscle medullary collecting duct neural tube ganglionic eminence superior frontal gyrus maxillary prominence endocardial cushion cerebellar cortex thymus More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II complex binding enzyme inhibitor activity protein binding enzyme binding RNA binding nuclear receptor coactivator activity Cellular component cytoplasm nucleoplasm DBIRD complex mitochondrial matrix spliceosomal complex nucleus Biological process mitochondrial fragmentation involved in apoptotic process negative regulation of catalytic activity regulation of transcription, DNA-templated regulation of protein stability positive regulation of DNA damage checkpoint rhythmic process positive regulation of canonical Wnt signaling pathway mRNA processing regulation of DNA-templated transcription, elongation regulation of protein deacetylation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Wnt signaling pathway transcription, DNA-templated cellular response to DNA damage stimulus regulation of circadian rhythm negative regulation of cell growth RNA splicing negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of apoptotic process regulation of cellular response to heat cell cycle negative regulation of transcription, DNA-templated response to UV apoptotic process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57805 219158 Ensembl ENSG00000158941 ENSMUSG00000033712 UniProt Q8N163 Q8VDP4 RefSeq (mRNA) NM_021174 NM_199205 NM_001363068 NM_001363069 NM_001393997 NM_146055 RefSeq (protein) NP_066997 NP_001349997 NP_001349998 NP_666167 Location (UCSC) Chr 8: 22.6 – 22.62 Mb Chr 14: 70.38 – 70.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene. ^{[5] [6] [7]}

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53. ^{[8] [9]} DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000158941 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033712 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KIAA1967 KIAA1967".
6. Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID   11853319.
7. Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. Bibcode:2002PNAS...9913647H. doi: 10.1073/pnas.212516099 . PMC   129730 . PMID   12370419.
8. Kim JE, Chen J, Lou Z (January 2008). "DBC1 is a negative regulator of SIRT1". Nature. 451 (7178): 583–6. Bibcode:2008Natur.451..583K. doi:10.1038/nature06500. PMID   18235501. S2CID   4420753.
9. Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (January 2008). "Negative regulation of the deacetylase SIRT1 by DBC1". Nature. 451 (7178): 587–90. Bibcode:2008Natur.451..587Z. doi:10.1038/nature06515. PMC   2866287 . PMID   18235502.
10. Anantharaman V, Aravind L (May 2008). "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites". Cell Cycle. 7 (10): 1467–72. doi:10.4161/cc.7.10.5883. PMC   2423810 . PMID   18418069.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID   11853319.
• Hamaguchi M, Meth JL, von Klitzing C, et al. (2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. Bibcode:2002PNAS...9913647H. doi: 10.1073/pnas.212516099 . PMC   129730 . PMID   12370419.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Sundararajan R, Chen G, Mukherjee C, White E (2005). "Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling". Oncogene. 24 (31): 4908–20. doi:10.1038/sj.onc.1208681. PMID   15824730. S2CID   28591041.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach". Cell Cycle. 6 (2): 205–17. doi: 10.4161/cc.6.2.3742 . PMID   17314511.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Trauernicht AM, Kim SJ, Kim NH, Boyer TG (2007). "Modulation of estrogen receptor alpha protein level and survival function by DBC-1". Mol. Endocrinol. 21 (7): 1526–36. doi: 10.1210/me.2007-0064 . PMID   17473282.