DBC1

This article is about Deleted in bladder cancer protein 1. For breast cancer, see Deleted in Breast Cancer 1 (DBC1). For DBC 1 (radio station), see Digital Broadcasting Corporation (Hong Kong).

BRINP1
Identifiers
Aliases	BRINP1 , DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDs	OMIM: 602865; MGI: 1928478; HomoloGene: 8754; GeneCards: BRINP1; OMA:BRINP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q33.1 Start 119,153,458 bp [1] End 119,369,435 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C1 Start 68,679,751 bp [2] End 68,872,634 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 entorhinal cortex primary visual cortex postcentral gyrus superior frontal gyrus Brodmann area 46 prefrontal cortex frontal pole buccal mucosa cell Top expressed in visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell hippocampus proper piriform cortex prefrontal cortex primary motor cortex subdivision of hippocampus dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm soma dendrite endoplasmic reticulum Biological process cell cycle negative regulation of cell cycle cell death behavioral fear response positive regulation of neuron differentiation negative regulation of neurogenesis social behavior cellular response to retinoic acid negative regulation of mitotic cell cycle short-term memory exploration behavior Maternal behavior vocalization behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1620 56710 Ensembl ENSG00000078725 ENSMUSG00000028351 UniProt O60477 Q920P3 RefSeq (mRNA) NM_014618 NM_019967 RefSeq (protein) NP_055433 NP_064351 Location (UCSC) Chr 9: 119.15 – 119.37 Mb Chr 4: 68.68 – 68.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene. ^{[5] [6] [7] [8] [9]}

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. ^[7]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

1. GRCh38: Ensembl release 89: ENSG00000078725 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028351 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi: 10.1093/hmg/6.6.913 . PMID   9175739.
6. Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID   10444335.
7. "Entrez Gene: DBC1 deleted in bladder cancer 1".
8. Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi: 10.1093/hmg/6.6.913 . PMID   9175739.
9. Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID   10444335.

Further reading

• Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID   7757816.
• Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33". Genomics. 48 (3): 277–88. doi:10.1006/geno.1997.5165. PMID   9545632.
• Nishiyama H, Takahashi T, Kakehi Y, et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer". Genes Chromosomes Cancer. 26 (2): 171–5. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID   10469456. S2CID   29396978.
• Nishiyama H, Gill JH, Pitt E, et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1". Oncogene. 20 (23): 2956–64. doi: 10.1038/sj.onc.1204432 . PMID   11420708. S2CID   3374427.
• Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors". J. Urol. 168 (6): 2645–9. doi:10.1016/s0022-5347(05)64236-x. PMID   12442002.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82–90. doi: 10.1038/sj.onc.1206642 . PMID   14712213. S2CID   3620390.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beetz C, Brodoehl S, Patt S, et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma". Oncol. Rep. 13 (2): 335–40. doi:10.3892/or.13.2.335 (inactive 11 July 2025). PMID   15643521.
• Izumi H, Inoue J, Yokoi S, et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers". Hum. Mol. Genet. 14 (8): 997–1007. doi: 10.1093/hmg/ddi092 . PMID   15746151.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Louhelainen JP, Hurst CD, Pitt E, et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway". Oncogene. 25 (16): 2409–19. doi: 10.1038/sj.onc.1209228 . PMID   16369496. S2CID   3349365.