DBC1

BRINP1
Identifiers
Aliases	BRINP1 , DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDs	OMIM: 602865; MGI: 1928478; HomoloGene: 8754; GeneCards: BRINP1; OMA:BRINP1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	119,369,435 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	68,872,634 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; entorhinal cortex; ; primary visual cortex; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 46; ; prefrontal cortex; ; frontal pole; ; buccal mucosa cell;
	Top expressed in
	visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; piriform cortex; ; prefrontal cortex; ; primary motor cortex; ; subdivision of hippocampus; ; dorsal striatum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; neuronal cell body ; dendrite ; endoplasmic reticulum ;
Biological process	cell cycle ; negative regulation of cell cycle ; cell death ; behavioral fear response ; positive regulation of neuron differentiation ; negative regulation of neurogenesis ; social behavior ; cellular response to retinoic acid ; negative regulation of mitotic cell cycle ; short-term memory ; exploration behavior ; maternal behavior ; vocalization behavior ;
	Sources:Amigo / QuickGO
Orthologs
	1620
	56710
	ENSG00000078725
	ENSMUSG00000028351
	O60477
	Q920P3
	NM_014618
	NM_019967
	NP_055433
	NP_064351
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 13, 2024

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.^[5]^[6]^[7]^[8]^[9]

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.^[7]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078725 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028351 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi: 10.1093/hmg/6.6.913 . PMID 9175739.
↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
1 2 "Entrez Gene: DBC1 deleted in bladder cancer 1".
↑ Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi: 10.1093/hmg/6.6.913 . PMID 9175739.
↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33". Genomics. 48 (3): 277–88. doi:10.1006/geno.1997.5165. PMID 9545632.
Nishiyama H, Takahashi T, Kakehi Y, et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer". Genes Chromosomes Cancer. 26 (2): 171–5. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456. S2CID 29396978.
Nishiyama H, Gill JH, Pitt E, et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1". Oncogene. 20 (23): 2956–64. doi: 10.1038/sj.onc.1204432 . PMID 11420708. S2CID 3374427.
Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors". J. Urol. 168 (6): 2645–9. doi:10.1016/s0022-5347(05)64236-x. PMID 12442002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82–90. doi: 10.1038/sj.onc.1206642 . PMID 14712213. S2CID 3620390.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Beetz C, Brodoehl S, Patt S, et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma". Oncol. Rep. 13 (2): 335–40. doi:10.3892/or.13.2.335 (inactive 2024-09-12). PMID 15643521.{{cite journal}}: CS1 maint: DOI inactive as of September 2024 (link)
Izumi H, Inoue J, Yokoi S, et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers". Hum. Mol. Genet. 14 (8): 997–1007. doi: 10.1093/hmg/ddi092 . PMID 15746151.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Louhelainen JP, Hurst CD, Pitt E, et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway". Oncogene. 25 (16): 2409–19. doi: 10.1038/sj.onc.1209228 . PMID 16369496. S2CID 3349365.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000078725 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028351 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9175739-5] Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi: 10.1093/hmg/6.6.913 . PMID 9175739.

[pmid10444335-6] Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

[entrez-7] 1 2 "Entrez Gene: DBC1 deleted in bladder cancer 1".

[autogenerated1-8] Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi: 10.1093/hmg/6.6.913 . PMID 9175739.

[autogenerated2-9] Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

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DBC1

Related Research Articles

References

Further reading