BRINP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | BRINP1 , DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602865 MGI: 1928478 HomoloGene: 8754 GeneCards: BRINP1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene. [5] [6] [7] [8] [9]
This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [7]
The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.
p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. It is involved in cell cycle regulation, and induction of apoptosis. Like p53, p73 is characterized by the presence of different isoforms of the protein. This is explained by splice variants, and an alternative promoter in the DNA sequence.
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.
Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog , also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene.
Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.
Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.
Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene. ST7 orthologs have been identified in all mammals for which complete genome data are available.
Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene.
RNA-binding protein 5 is a protein that in humans is encoded by the RBM5 gene.
Zinc finger MYND domain-containing protein 10 is a protein that in humans is encoded by the ZMYND10 gene.
KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.
Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.
Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.
Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.
Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.
Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene. It encodes a protein that performs posttranslational modification of histidine-715 on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation of Cyclin D in ovarian cells. DPH1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.
Deleted in lymphocytic leukemia 2 is a long non-coding RNA that in humans is encoded by the DLEU2 gene. In humans it is located on chromosome 13q14. The DLEU2 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.
Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.
Tumor suppressor candidate 2 is a protein that in humans is encoded by the TUSC2 gene.
Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.
Zinc phosphodiesterase ELAC protein 1 is an enzyme that in humans is encoded by the ELAC1 gene.
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: CS1 maint: DOI inactive as of January 2024 (link)