IFNA8

IFNA8
Identifiers
Aliases	IFNA8 , IFN-alphaB, interferon alpha 8
External IDs	OMIM: 147568; MGI: 2667155; HomoloGene: 68237; GeneCards: IFNA8; OMA:IFNA8 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.3 Start 21,409,117 bp [1] End 21,410,185 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 C4|4 42.02 cM Start 88,561,878 bp [2] End 88,562,696 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum primary visual cortex prefrontal cortex Top expressed in embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response innate immune response cytokine-mediated signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3445 230396 Ensembl ENSG00000120242 ENSMUSG00000063376 UniProt P32881 Q80SU4 RefSeq (mRNA) NM_002170 NM_177347 RefSeq (protein) NP_002161 NP_796321 Location (UCSC) Chr 9: 21.41 – 21.41 Mb Chr 4: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000120242 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID   1385305.
6. "Entrez Gene: IFNA8 interferon, alpha 8". Archived from the original on 2010-12-05. Retrieved 2017-08-31.

Further reading

• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID   4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID   6163083. S2CID   1900300.
• Yelverton E, Leung D, Weck P, et al. (1981). "Bacterial synthesis of a novel human leukocyte interferon". Nucleic Acids Res. 9 (3): 731–41. doi:10.1093/nar/9.3.731. PMC   327233 . PMID   6164048.
• Bowden DW, Mao J, Gill T, et al. (1984). "Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes". Gene. 27 (1): 87–99. doi:10.1016/0378-1119(84)90241-5. PMID   6325303.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC   231390 . PMID   8668211.
• Hussain M, Gill DS, Liao MJ, Testa D (1997). "Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population". J. Interferon Cytokine Res. 16 (7): 523–9. doi:10.1089/jir.1996.16.523. PMID   8836918.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2) (2): 295–302. doi:10.1042/bj3290295. PMC   1219044 . PMID   9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID   15233997.