IFNA17

IFNA17
Identifiers
Aliases	IFNA17 , IFN-alphaI, IFNA, INFA, LEIF2C1, interferon, alpha 17, interferon alpha 17
External IDs	OMIM: 147583 HomoloGene: 117990 GeneCards: IFNA17
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,228,222 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity ; type I interferon receptor binding ; cytokine receptor binding ;
Cellular component	extracellular region ; extracellular space ;
Biological process	natural killer cell activation involved in immune response ; B cell differentiation ; defense response ; response to virus ; B cell proliferation ; blood coagulation ; positive regulation of peptidyl-serine phosphorylation of STAT protein ; humoral immune response ; adaptive immune response ; defense response to virus ; type I interferon signaling pathway ; response to exogenous dsRNA ; T cell activation involved in immune response ; cytokine-mediated signaling pathway ; innate immune response ; regulation of signaling receptor activity ;
	Sources:Amigo / QuickGO
Orthologs
	3451
	n/a
	ENSG00000234829
	n/a
	P01571
	n/a
	NM_021268
	n/a
	NP_067091
	n/a
	Wikidata
View/Edit Human

Last updated October 14, 2022

Interferon alpha-17 is a protein that in humans is encoded by the IFNA17 gene.^[3]^[4]

Related Research Articles

Interferons are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.

Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among species but include potentiation of Interferon gamma (IFN-II) production in lymphocytes, ubiquitin-like conjugation to newly-synthesized proteins and negative regulation of the IFN-I response.

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.

Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene.

Interferon beta is a protein that in humans is encoded by the IFNB1 gene. The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.

Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. It was also produced in 1986 in recombinant human form, in the Center for Genetic Engineering and Biotechnology of Havana, Cuba, under the name Heberon Alfa R.

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.

Interferon alpha-4 is a protein that in humans is encoded by the IFNA4 gene.

Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene.

Interferon alpha-14 is a protein that in humans is encoded by the IFNA14 gene.

Interferon omega-1 is a protein that in humans is encoded by the IFNW1 gene.

Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene.

Interferon alpha-10 is a protein that in humans is encoded by the IFNA10 gene.

Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene.

Interferon alpha-21 is a protein that in humans is encoded by the IFNA21 gene.

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.

Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.

Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000234829 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
↑ "Entrez Gene: IFNA17 interferon, alpha 17".

Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. doi: 10.1016/S0021-9258(18)42719-6 . PMID 1371992.
Zoon KC, Miller D, Bekisz J, et al. (1992). "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha". J. Biol. Chem. 267 (21): 15210–6. doi: 10.1016/S0021-9258(18)42167-9 . PMID 1634550.
Savel'ev VI, Zlochevskiĭ ML, Sorokin AV, et al. (1986). "[Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons]". Antibiot. Med. Biotekhnol. 31 (8): 592–6. PMID 3767336.
Mizoguchi J, Pitha PM, Raj NB (1985). "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules". DNA. 4 (3): 221–32. doi:10.1089/dna.1985.4.221. PMID 3891272.
Lund B, von Gabain A, Edlund T, et al. (1985). "Differential expression of interferon genes in a substrain of Namalwa cells". J. Interferon Res. 5 (2): 229–38. doi:10.1089/jir.1985.5.229. PMID 4008999.
Lawn RM, Adelman J, Dull TJ, et al. (1981). "DNA sequence of two closely linked human leukocyte interferon genes". Science. 212 (4499): 1159–62. Bibcode:1981Sci...212.1159L. doi:10.1126/science.6165082. PMID 6165082.
Fuke M, Hendrix LC, Bollon AP (1985). "Pseudogene IFN-alpha L: removal of the stop codon in the signal sequence permits expression of active human interferon". Gene. 32 (1–2): 135–40. doi:10.1016/0378-1119(84)90041-6. PMID 6397400.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390 . PMID 8668211.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (2): 295–302. doi:10.1042/bj3290295. PMC 1219044 . PMID 9425112.
Hussain M, Tan T, Ni D, et al. (1998). "A new allele of interferon-alpha17 gene encoding IFN-alpha17b is the major variant in human population". J. Interferon Cytokine Res. 18 (7): 469–77. doi:10.1089/jir.1998.18.469. PMID 9712362.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kim JW, Roh JW, Park NH, et al. (2003). "Interferon, alpha 17 (IFNA17) Ile184Arg polymorphism and cervical cancer risk". Cancer Lett. 189 (2): 183–8. doi:10.1016/S0304-3835(02)00548-7. PMID 12490311.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000234829 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1385305-3] Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

[entrez-4] "Entrez Gene: IFNA17 interferon, alpha 17".

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IFNA17

Related Research Articles

References

Further reading