IFNA13

IFNA13
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3UX9
Identifiers
Aliases	IFNA13 , interferon alpha 13
External IDs	OMIM: 147578 HomoloGene: 136811 GeneCards: IFNA13
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,368,962 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; putamen; ; caudate nucleus; ; Brodmann area 9; ; amygdala; ; hippocampus proper; ; gastric mucosa; ; stromal cell of endometrium; ; substantia nigra; ; superior frontal gyrus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity ; type I interferon receptor binding ; cytokine receptor binding ;
Cellular component	extracellular region ; extracellular space ;
Biological process	natural killer cell activation involved in immune response ; B cell differentiation ; defense response ; B cell proliferation ; blood coagulation ; positive regulation of peptidyl-serine phosphorylation of STAT protein ; humoral immune response ; adaptive immune response ; defense response to virus ; type I interferon signaling pathway ; response to exogenous dsRNA ; T cell activation involved in immune response ; cytokine-mediated signaling pathway ; innate immune response ; regulation of signaling receptor activity ;
	Sources:Amigo / QuickGO
Orthologs
	3447
	n/a
	ENSG00000233816
	n/a
	P01562
	n/a
	NM_006900
	n/a
	NP_076918
	n/a
	Wikidata
View/Edit Human

Last updated February 26, 2024

Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.^[3]^[4]

Related Research Articles

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Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene.

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Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.

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Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. It was also produced in 1986 in recombinant human form, in the Center for Genetic Engineering and Biotechnology of Havana, Cuba, under the name Heberon Alfa R.

Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene.

Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene. IFITM1 has also recently been designated CD225. This protein has several additional names: fragilis, IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13.

Interferon alpha-17 is a protein that in humans is encoded by the IFNA17 gene.

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Interferon, type 1, cluster, also known as IFN1@, is a human gene.

Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene.

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Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.

Interferon alpha-16, also known as IFN-alpha-16, is a protein that in humans is encoded by theIFNA16 gene.

Interferon lambda 3 encodes the IFNL3 protein. IFNL3 was formerly named IL28B, but the Human Genome Organization Gene Nomenclature Committee renamed this gene in 2013 while assigning a name to the then newly discovered IFNL4 gene. Together with IFNL1 and IFNL2, these genes lie in a cluster on chromosomal region 19q13. IFNL3 shares ~96% amino-acid identity with IFNL2, ~80% identity with IFNL1 and ~30% identity with IFNL4.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000233816 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: interferon".
↑ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (October 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (2): 295–302. doi:10.1042/bj3290295. PMC 1219044 . PMID 9425112.
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Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G (2007). "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes". Genomics. 89 (3): 307–15. doi:10.1016/j.ygeno.2006.11.012. PMC 4647941 . PMID 17207965.
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Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
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Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898 . PMID 20588308.
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IFNA13 is an interferon gene.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000233816 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: interferon".

[pmid1385305-4] Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (October 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

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IFNA13

Related Research Articles

References

Further reading