CXCL13

CXCL13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZAI, 5CBA, 5CBE
Identifiers
Aliases	CXCL13 , ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine ligand 13
External IDs	OMIM: 605149; MGI: 1888499; HomoloGene: 48431; GeneCards: CXCL13; OMA:CXCL13 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q21.1 Start 77,511,753 bp [1] End 77,611,834 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 E3 Start 96,104,810 bp [2] End 96,108,927 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen lymph node appendix mucosa of ileum epithelium of nasopharynx rectum periodontal fiber tonsil superficial temporal artery decidua Top expressed in spleen mesenteric lymph nodes migratory enteric neural crest cell morula submandibular gland tunica adventitia of aorta subcutaneous adipose tissue Paneth cell white adipose tissue external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function receptor ligand activity CCR10 chemokine receptor binding cytokine activity heparin binding CXCR3 chemokine receptor binding chemokine activity protein heterodimerization activity fibroblast growth factor binding CXCR5 chemokine receptor binding Cellular component extracellular region extracellular space Biological process chemokine-mediated signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling germinal center formation regulation of angiogenesis chemotaxis endothelial cell chemotaxis to fibroblast growth factor regulation of humoral immune response cell surface receptor signaling pathway response to lipopolysaccharide regulation of cell population proliferation defense response to bacterium negative regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of T cell chemotaxis immune response inflammatory response chronic inflammatory response defense response antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway lymphocyte chemotaxis across high endothelial venule positive regulation of integrin activation positive regulation of cell-cell adhesion mediated by integrin B cell chemotaxis activation of GTPase activity neutrophil chemotaxis leukocyte chemotaxis cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10563 55985 Ensembl ENSG00000156234 ENSMUSG00000023078 UniProt O43927 O55038 RefSeq (mRNA) NM_006419 NM_001371558 NM_018866 RefSeq (protein) NP_006410 NP_001358487 NP_061354 Location (UCSC) Chr 4: 77.51 – 77.61 Mb Chr 5: 96.1 – 96.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene. ^{[5] [6]}

Function

CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. ^{[5] [7]} CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues ^[8] and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. ^[5] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines. ^[6]

In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or T_FH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000156234 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023078 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC   2212150 . PMID   9463416.
6. Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. Bibcode:1998Natur.391..799G. doi:10.1038/35876. PMID   9486651. S2CID   4373691.
7. Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi: 10.1016/S1074-7613(01)00257-6 . PMID   11825566.
8. Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID   10917533. S2CID   4369622.
9. de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi: 10.1182/blood-2006-10-055145 . PMID   17284527.

External links

• Human CXCL13 genome location and CXCL13 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : O43927 (C-X-C motif chemokine 13) at the PDBe-KB .