IL1F10

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IL1F10
Identifiers
Aliases	IL1F10 , FIL1-theta, IL-1HY2, IL-38, IL1-theta, IL1HY2, FKSG75, interleukin 1 family member 10 (theta), interleukin 1 family member 10
External IDs	OMIM: 615296; MGI: 2652548; GeneCards: IL1F10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5BOW
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q14.1 Start 113,067,970 bp [1] End 113,075,843 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 A3|2 16.32 cM Start 24,181,208 bp [2] End 24,183,832 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of limb skin of leg skin of abdomen skin of thigh human penis amniotic fluid gonad pharynx tonsil placenta Top expressed in lip skin of abdomen skin of external ear skin of back hair follicle cervix thymus More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity interleukin-1 receptor binding Cellular component extracellular space extracellular region Biological process inflammatory response immune response regulation of signaling receptor activity cytokine-mediated signaling pathway cellular response to cytokine stimulus neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 84639 215274 Ensembl ENSG00000136697 ENSMUSG00000046845 UniProt Q8WWZ1 Q8R459 RefSeq (mRNA) NM_173161 NM_032556 NM_153077 RefSeq (protein) NP_115945 NP_775184 NP_694717 Location (UCSC) Chr 2: 113.07 – 113.08 Mb Chr 2: 24.18 – 24.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene. ^{[5] [6] [7] [8]}

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000136697 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046845 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14". J Interferon Cytokine Res. 21 (11): 899–904. doi:10.1089/107999001753289505. PMID   11747621.
6. Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics. 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID   11991723.
7. Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID   11991722.
8. "Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)".

Further reading

• Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID   8188271.
• Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics. 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID   9169134.
• Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID   10512743.
• Smith DE, Renshaw BR, Ketchem RR, et al. (2000). "Four new members expand the interleukin-1 superfamily". J. Biol. Chem. 275 (2): 1169–75. doi: 10.1074/jbc.275.2.1169 . PMID   10625660.
• Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J. Biol. Chem. 275 (14): 10308–14. doi: 10.1074/jbc.275.14.10308 . PMID   10744718.
• Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID   10860666.
• Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". Eur. J. Immunol. 30 (11): 3299–308. doi: 10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S . PMID   11093146.
• Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID   11145836.
• Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi: 10.1074/jbc.M010095200 . PMID   11278614.
• Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID   11466363. S2CID   85986577.
• Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes". Trends Immunol. 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID   11574262.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.