IL1RL2

Last updated
IL1RL2
Identifiers
Aliases IL1RL2 , IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, interleukin 1 receptor like 2
External IDs OMIM: 604512; MGI: 1913107; HomoloGene: 2860; GeneCards: IL1RL2; OMA:IL1RL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_133193
NM_001356478

RefSeq (protein)

NP_573456
NP_001343407

Location (UCSC) Chr 2: 102.19 – 102.24 Mb Chr 1: 40.36 – 40.41 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene. [5] [6] [7] [8]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115598 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070942 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID   8898719. S2CID   53171191.
  6. Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID   10191101.
  7. Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi: 10.4049/jimmunol.167.3.1440 . PMID   11466363.
  8. 1 2 "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

Further reading