Interleukin 1 receptor, type II

Last updated

IL1R2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL1R2 , CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2
External IDs OMIM: 147811; MGI: 96546; HomoloGene: 7783; GeneCards: IL1R2; OMA:IL1R2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261419
NM_004633
NM_173343

NM_010555
NM_001360800
NM_001360801

RefSeq (protein)

NP_001248348
NP_004624

NP_034685
NP_001347729
NP_001347730

Location (UCSC) Chr 2: 101.99 – 102.03 Mb Chr 1: 40.11 – 40.16 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

Contents

Function

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP, [5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography. [6] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115590 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026073 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, et al. (December 1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877. doi: 10.4049/jimmunol.161.12.6871 . PMID   9862719. S2CID   8940186.
  6. Wang D, Zhang S, Li L, Liu X, Mei K, Wang X (October 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925. PMID   20802483. S2CID   20315956.
  7. "Entrez Gene: IL1R2 interleukin 1 receptor, type II".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.