CD3D

CD3D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XIW
Identifiers
Aliases	CD3D , CD3-DELTA, IMD19, T3D, CD3d molecule, CD3 delta subunit of T-cell receptor complex, CD3DELTA
External IDs	OMIM: 186790; MGI: 88331; HomoloGene: 585; GeneCards: CD3D; OMA:CD3D - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,342,705 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,898,637 bp
RNA expression pattern
	Top expressed in
	thymus; ; granulocyte; ; lymph node; ; appendix; ; blood; ; spleen; ; epithelium of nasopharynx; ; testicle; ; mucosa of ileum; ; bone marrow;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; granulocyte; ; subcutaneous adipose tissue; ; pharynx; ; right lung lobe; ; spermatid; ; superior surface of tongue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity ; protein heterodimerization activity ; transmembrane signaling receptor activity ; protein homodimerization activity ;
Cellular component	membrane ; cytoplasm ; alpha-beta T cell receptor complex ; integral component of membrane ; T cell receptor complex ; clathrin-coated vesicle membrane ; plasma membrane ; external side of plasma membrane ;
Biological process	positive regulation of transcription by RNA polymerase II ; regulation of immune response ; T cell receptor signaling pathway ; T cell differentiation ; positive thymic T cell selection ; cell surface receptor signaling pathway ; membrane organization ; protein homooligomerization ; adaptive immune response ; immune system process ;
	Sources:Amigo / QuickGO
Orthologs
	915
	12500
	ENSG00000167286
	ENSMUSG00000032094
	P04234
	P04235
	NM_001040651 ; NM_000732
	NM_013487
	NP_000723 ; NP_001035741
	NP_038515
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 18, 2025

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.^[5]

Interactions

CD3D has been shown to interact with CD8A.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167286 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032094 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)".
↑ Doucey MA, Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). United States: 3257–64. doi: 10.1074/jbc.M208119200 . ISSN 0021-9258. PMID 12215456.

Balk SP, Polischuk JE, Probert C, et al. (1996). "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int. Immunol. 7 (8): 1237–41. doi:10.1093/intimm/7.8.1237. PMID 7495730.
Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685. S2CID 37846031.
Phillips JH, Hori T, Nagler A, et al. (1992). "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins". J. Exp. Med. 175 (4): 1055–66. doi:10.1084/jem.175.4.1055. PMC 2119193 . PMID 1372642.
Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.
Alarcón B, Ley SC, Sánchez-Madrid F, et al. (1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes". EMBO J. 10 (4): 903–12. doi:10.1002/j.1460-2075.1991.tb08023.x. PMC 452733 . PMID 1826255.
Hori T, de Waal Malefyt R, Duncan BW, et al. (1991). "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3". Int. Immunol. 3 (4): 353–7. doi:10.1093/intimm/3.4.353. PMID 1831653.
Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx". Cell. Immunol. 137 (1): 1–13. doi: 10.1016/0008-8749(91)90051-C . PMID 1832084.
Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852 . PMID 1979339.
Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV". Folia Biol. (Praha). 36 (1): 71–7. PMID 2111780.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083. S2CID 2180901.
Alexander D, Goris J, Marais R, et al. (1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55–65. doi:10.1111/j.1432-1033.1989.tb14693.x. PMID 2540970.
Tunnacliffe A, Buluwela L, Rabbitts TH (1988). "Physical linkage of three CD3 genes on human chromosome 11". EMBO J. 6 (10): 2953–7. doi:10.1002/j.1460-2075.1987.tb02600.x. PMC 553731 . PMID 2826124.
van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein". Nature. 314 (6011): 542–4. Bibcode:1985Natur.314..542V. doi:10.1038/314542a0. PMID 2859526. S2CID 4321989.
van den Elsen P, Georgopoulos K, Shepley BA, et al. (1986). "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex". Proc. Natl. Acad. Sci. U.S.A. 83 (9): 2944–8. Bibcode:1986PNAS...83.2944V. doi: 10.1073/pnas.83.9.2944 . PMC 323423 . PMID 2939461.
Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. Bibcode:1987PNAS...84.7649G. doi: 10.1073/pnas.84.21.7649 . PMC 299357 . PMID 3478717.
Tunnacliffe A, Sims JE, Rabbitts TH (1986). "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells". EMBO J. 5 (6): 1245–52. doi:10.1002/j.1460-2075.1986.tb04353.x. PMC 1166934 . PMID 3488209.
van den Elsen P, Shepley BA, Borst J, et al. (1985). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993): 413–8. Bibcode:1984Natur.312..413V. doi:10.1038/312413a0. PMID 6095101. S2CID 4347265.
Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120". AIDS Res. Hum. Retroviruses. 9 (10): 945–55. doi:10.1089/aid.1993.9.945. PMID 7506554.
Luzzati AL, Giacomini E, Giordani L, et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex". Cell. Immunol. 156 (2): 286–95. doi:10.1006/cimm.1994.1175. PMID 7517794.

External links

Human CD3D genome location and CD3D gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : P04234 (T-cell surface glycoprotein CD3 delta chain) at the PDBe-KB .
PDBe-KB provides an overview of all the structure information available in the PDB for Human T-cell surface glycoprotein CD3 delta chain (CD3D)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167286 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)".

[pmid12215456-6] Doucey MA, Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5). United States: 3257–64. doi: 10.1074/jbc.M208119200 . ISSN 0021-9258. PMID 12215456.

[1]

[2]

[3]

[4]

[5]

[6]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CD3D

Contents

Interactions

See also

References

Further reading

External links