CD151

CD151
Identifiers
Aliases	CD151 , GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group), EBS7
External IDs	OMIM: 602243; MGI: 1096360; HomoloGene: 20916; GeneCards: CD151; OMA:CD151 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	839,831 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,051,386 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; stromal cell of endometrium; ; apex of heart; ; body of pancreas; ; upper lobe of left lung;
	Top expressed in
	endothelial cell of lymphatic vessel; ; medullary collecting duct; ; Paneth cell; ; renal corpuscle; ; iris; ; tunica media of zone of aorta; ; carotid body; ; tunica adventitia of aorta; ; ciliary body; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding ; protein binding ;
Cellular component	cytosol ; membrane ; focal adhesion ; basement membrane ; integral component of membrane ; integral component of plasma membrane ; plasma membrane ; cell surface ;
Biological process	cell adhesion ; cell surface receptor signaling pathway ; hemidesmosome assembly ; T cell proliferation ; cell migration ; positive regulation of cell migration ; wound healing, spreading of cells ; positive regulation of endocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	977
	12476
	ENSG00000177697
	ENSMUSG00000025510
	P48509 ; Q6ZNZ0
	O35566
	NM_139030 ; NM_001039490 ; NM_004357 ; NM_139029
	NM_001111049 ; NM_001111050 ; NM_009842
NP_001034579 ; NP_004348 ; NP_620598 ; NP_620599 ; NP_001034579.1 ;
	NP_004348.2 ; NP_620598.1 ; NP_620599.1
	NP_001104519 ; NP_001104520 ; NP_033972
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 17, 2025

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.^[5]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.^[5] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.^[6]^[7]

Interactions

CD151 has been shown to interact with CD46.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177697 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025510 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CD151 CD151 molecule (Raph blood group)".
↑ Bardhan A, Bruckner-Tuderman L, Chapple IL, Fine JD, Harper N, Has C, et al. (September 2020). "Epidermolysis bullosa". Nature Reviews. Disease Primers. 6 (1) 78. doi:10.1038/s41572-020-0210-0. PMID 32973163. S2CID 221861310.
↑ Vahidnezhad H, Youssefian L, Saeidian AH, Mahmoudi H, Touati A, Abiri M, et al. (March 2018). "Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy". Matrix Biology. 66: 22–33. doi:10.1016/j.matbio.2017.11.003. hdl: 11573/1182681 . PMID 29138120. S2CID 3812225.
↑ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, et al. (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". European Journal of Immunology. 30 (3): 900–907. doi: 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X . PMID 10741407.

Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–4151. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Ashman LK (2003). "CD151". Journal of Biological Regulators and Homeostatic Agents. 16 (3): 223–226. PMID 12456024.
Ashman LK, Aylett GW, Mehrabani PA, Bendall LJ, Niutta S, Cambareri AC, et al. (October 1991). "The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen". British Journal of Haematology. 79 (2): 263–270. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID 1958484. S2CID 6682391.
Fitter S, Tetaz TJ, Berndt MC, Ashman LK (August 1995). "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood. 86 (4): 1348–1355. doi: 10.1182/blood.V86.4.1348.bloodjournal8641348 . hdl: 2440/103301 . PMID 7632941.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hasegawa H, Utsunomiya Y, Kishimoto K, Yanagisawa K, Fujita S (May 1996). "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily". Journal of Virology. 70 (5): 3258–3263. doi:10.1128/JVI.70.5.3258-3263.1996. PMC 190191 . PMID 8627808.
Hasegawa H, Kishimoto K, Yanagisawa K, Terasaki H, Shimadzu M, Fujita S (February 1997). "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization". Genomics. 40 (1): 193–196. doi:10.1006/geno.1996.4563. PMID 9070943.
Sincock PM, Mayrhofer G, Ashman LK (April 1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". The Journal of Histochemistry and Cytochemistry. 45 (4): 515–525. doi: 10.1177/002215549704500404 . PMID 9111230.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Fitter S, Seldin MF, Ashman LK (May 1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1398 (1): 75–85. doi:10.1016/S0167-4781(98)00034-7. PMID 9602068.
Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK (March 1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". Journal of Cell Science. 112 ( Pt 6) (6): 833–844. doi:10.1242/jcs.112.6.833. hdl: 2440/8940 . PMID 10036233.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, et al. (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (Pt 1): 103–111. doi:10.1042/0264-6021:3400103. PMC 1220227 . PMID 10229664.
Testa JE, Brooks PC, Lin JM, Quigley JP (August 1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Research. 59 (15): 3812–3820. PMID 10447000.
Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A (May 2000). "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes". The Journal of Cell Biology. 149 (4): 969–982. doi:10.1083/jcb.149.4.969. PMC 2174566 . PMID 10811835.
Whittock NV, McLean WH (February 2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene". Biochemical and Biophysical Research Communications. 281 (2): 425–430. Bibcode:2001BBRC..281..425W. doi:10.1006/bbrc.2001.4384. PMID 11181065.
Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, et al. (April 2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". The Journal of Biological Chemistry. 276 (17): 14329–14337. doi: 10.1074/jbc.M011297200 . PMID 11278880.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, et al. (May 2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Research. 11 (5): 677–684. doi:10.1101/gr.gr-1640r. PMC 311086 . PMID 11337467.
Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S (January 2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". International Journal of Cancer. 97 (3): 336–343. doi:10.1002/ijc.1605. PMID 11774285. S2CID 46569418.
Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME (January 2002). "Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis". Molecular Biology of the Cell. 13 (1): 1–11. doi:10.1091/mbc.01-10-0481. PMC 65068 . PMID 11809818.

External links

Raph blood group system in the BGMUT blood group antigen gene mutation database
Human CD151 genome location and CD151 gene details page in the UCSC Genome Browser .

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177697 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025510 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CD151 CD151 molecule (Raph blood group)".

[6] Bardhan A, Bruckner-Tuderman L, Chapple IL, Fine JD, Harper N, Has C, et al. (September 2020). "Epidermolysis bullosa". Nature Reviews. Disease Primers. 6 (1) 78. doi:10.1038/s41572-020-0210-0. PMID 32973163. S2CID 221861310.

[7] Vahidnezhad H, Youssefian L, Saeidian AH, Mahmoudi H, Touati A, Abiri M, et al. (March 2018). "Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy". Matrix Biology. 66: 22–33. doi:10.1016/j.matbio.2017.11.003. hdl: 11573/1182681 . PMID 29138120. S2CID 3812225.

[pmid10741407-8] Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, et al. (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". European Journal of Immunology. 30 (3): 900–907. doi: 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X . PMID 10741407.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

CD151

Contents

Function

Interactions

See also

References

Further reading

External links