TSPAN4

TSPAN4
Identifiers
Aliases	TSPAN4 , NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs	OMIM: 602644 MGI: 1928097 HomoloGene: 2453 GeneCards: TSPAN4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	867,116 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,073,340 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lung; ; left uterine tube; ; canal of the cervix; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; tibial nerve; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastric mucosa;
	Top expressed in
	calvaria; ; internal carotid artery; ; external carotid artery; ; adrenal gland; ; cerebellar cortex; ; ankle; ; renal corpuscle; ; rib; ; carotid body; ; cerebellar vermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	antigen binding ; integrin binding ; protein binding ;
Cellular component	integral component of membrane ; vesicle ; plasma membrane ; integral component of plasma membrane ; membrane ; focal adhesion ;
Biological process	cell surface receptor signaling pathway ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	7106
	64540
	ENSG00000214063
	ENSMUSG00000025511
	O14817
	Q9DCK3
NM_001025234 ; NM_001025235 ; NM_001025236 ; NM_001025237 ; NM_001025238 ;
	NM_001025239 ; NM_003271
	NM_001252588 ; NM_053082
NP_001020405 ; NP_001020406 ; NP_001020407 ; NP_001020408 ; NP_001020409 ;
	NP_001020410 ; NP_003262
NP_001239517 ; NP_444312 ; NP_001390284 ; NP_001390285 ; NP_001390286 ;
	NP_001390287
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 01, 2022

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.^[5]^[6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

TSPAN4 has been shown to interact with CD9,^[5] ITGA6,^[5] CD29,^[5] CD49c ^[5] and CD81.^[5]

Related Research Articles

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens.

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family. Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.

CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.

CD151 molecule, also known as CD151, is a human gene.

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

CD81 molecule, also known as CD81, is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1, and Tetraspanin-28 (Tspan-28).

CD82, or KAI1, is a human protein encoded by the CD82 gene.

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.

Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene. IGSF8 has also been designated as CD316.

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.

Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000214063 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025511 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 6 Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi: 10.1074/jbc.272.46.29181 . PMID 9360996.
1 2 "Entrez Gene: TSPAN4 tetraspanin 4".

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227 . PMID 10229664.
Yauch RL, Kazarov AR, Desai B, et al. (2000). "Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151". J. Biol. Chem. 275 (13): 9230–8. doi: 10.1074/jbc.275.13.9230 . PMID 10734060.
Lozahic S, Christiansen D, Manié S, et al. (2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi: 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X . PMID 10741407.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163 . PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. Bibcode:2003Sci...302.1960C. doi:10.1126/science.1088821. PMID 14671302. S2CID 6682593.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000214063 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025511 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9360996-5] 1 2 3 4 5 6 Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi: 10.1074/jbc.272.46.29181 . PMID 9360996.

[entrez-6] 1 2 "Entrez Gene: TSPAN4 tetraspanin 4".

[1]

[2]

[3]

[4]

[5]

[6]

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

TSPAN4

Contents

Interactions

Related Research Articles

References

Further reading