TSPAN4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | TSPAN4 , NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602644; MGI: 1928097; HomoloGene: 2453; GeneCards: TSPAN4; OMA:TSPAN4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene. [5] [6]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [6]
TSPAN4 has been shown to interact with CD9, [5] ITGA6, [5] CD29, [5] CD49c [5] and CD81. [5]